6DZQ

The N-terminal domain of PA endonuclease from the influenza H1N1 virus in complex with 3-hydroxy-6-methyl-4-oxo-4H-pyran-2-carboxylic acid

Summary for 6DZQ

Entry DOI	10.2210/pdb6dzq/pdb
Descriptor	Polymerase acidic protein, MANGANESE (II) ION, 3-hydroxy-6-methyl-4-oxo-4H-pyran-2-carboxylic acid, ... (5 entities in total)
Functional Keywords	inhibitor, endonuclease, influenza, pa domain, viral protein, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological source	Influenza A virus (A/California/04/2009(H1N1))
Total number of polymer chains	1
Total formula weight	22872.80
Authors	Dick, B.L.,Morrison, C.N.,Cohen, S.M. (deposition date: 2018-07-05, release date: 2018-11-07, Last modification date: 2023-10-11)
Primary citation	Credille, C.V.,Dick, B.L.,Morrison, C.N.,Stokes, R.W.,Adamek, R.N.,Wu, N.C.,Wilson, I.A.,Cohen, S.M. Structure-Activity Relationships in Metal-Binding Pharmacophores for Influenza Endonuclease. J. Med. Chem., 61:10206-10217, 2018 Cited by PubMed: 30351002 DOI: 10.1021/acs.jmedchem.8b01363 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.25 Å)

Structure validation