3NNW

Crystal structure of P38 alpha in complex with DP802

Summary for 3NNW

Entry DOI	10.2210/pdb3nnw/pdb
Related	3NNU 3NNV 3NNX
Descriptor	Mitogen-activated protein kinase 14, 2-[3-(3-tert-butyl-5-{[(2,3-dichlorophenyl)carbamoyl]imino}-2,5-dihydro-1H-pyrazol-1-yl)phenyl]acetamide (3 entities in total)
Functional Keywords	kinase, transferase
Biological source	Homo sapiens (human)
Cellular location	Cytoplasm : Q16539
Total number of polymer chains	1
Total formula weight	41069.81
Authors	Abendroth, J. (deposition date: 2010-06-24, release date: 2010-09-15, Last modification date: 2023-12-27)
Primary citation	Ahn, Y.M.,Clare, M.,Ensinger, C.L.,Hood, M.M.,Lord, J.W.,Lu, W.P.,Miller, D.F.,Patt, W.C.,Smith, B.D.,Vogeti, L.,Kaufman, M.D.,Petillo, P.A.,Wise, S.C.,Abendroth, J.,Chun, L.,Clark, R.,Feese, M.,Kim, H.,Stewart, L.,Flynn, D.L. Switch control pocket inhibitors of p38-MAP kinase. Durable type II inhibitors that do not require binding into the canonical ATP hinge region Bioorg.Med.Chem.Lett., 20:5793-5798, 2010 Cited by PubMed: 20800479 DOI: 10.1016/j.bmcl.2010.07.134 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.89 Å)

Structure validation