3NNX
Crystal structure of phosphorylated P38 alpha in complex with DP802
Summary for 3NNX
Entry DOI | 10.2210/pdb3nnx/pdb |
Related | 3NNU 3NNV 3NNW |
Descriptor | Mitogen-activated protein kinase 14, 2-[3-(3-tert-butyl-5-{[(2,3-dichlorophenyl)carbamoyl]imino}-2,5-dihydro-1H-pyrazol-1-yl)phenyl]acetamide (3 entities in total) |
Functional Keywords | kinase, transferase |
Biological source | Homo sapiens (human) |
Cellular location | Cytoplasm : Q16539 |
Total number of polymer chains | 1 |
Total formula weight | 41149.79 |
Authors | Abendroth, J. (deposition date: 2010-06-24, release date: 2010-09-15, Last modification date: 2024-10-16) |
Primary citation | Ahn, Y.M.,Clare, M.,Ensinger, C.L.,Hood, M.M.,Lord, J.W.,Lu, W.P.,Miller, D.F.,Patt, W.C.,Smith, B.D.,Vogeti, L.,Kaufman, M.D.,Petillo, P.A.,Wise, S.C.,Abendroth, J.,Chun, L.,Clark, R.,Feese, M.,Kim, H.,Stewart, L.,Flynn, D.L. Switch control pocket inhibitors of p38-MAP kinase. Durable type II inhibitors that do not require binding into the canonical ATP hinge region Bioorg.Med.Chem.Lett., 20:5793-5798, 2010 Cited by PubMed: 20800479DOI: 10.1016/j.bmcl.2010.07.134 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.28 Å) |
Structure validation
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