7XCE
 
 | | Crystal structure of Ankyrin G in complex with neurofascin | | 分子名称: | GLYCEROL, Neurofascin,Ankyrin-3, SULFATE ION | | 著者 | He, L, Li, J, Wang, C. | | 登録日 | 2022-03-24 | | 公開日 | 2022-09-21 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | | 主引用文献 | Crystal structure of Ankyrin-G in complex with a fragment of Neurofascin reveals binding mechanisms required for integrity of the axon initial segment.
J.Biol.Chem., 298, 2022
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7XJ2
 | | Structure of human TRPV3_G573S in complex with Trpvicin in C4 symmetry | | 分子名称: | Fusion protein of Transient receptor potential cation channel subfamily V member 3 and 3C-GFP, N-[5-[2-(2-cyanopropan-2-yl)pyridin-4-yl]-4-(trifluoromethyl)-1,3-thiazol-2-yl]-4,6-dimethoxy-pyrimidine-5-carboxamide | | 著者 | Fan, J, Yue, Z, Jiang, D, Lei, X. | | 登録日 | 2022-04-14 | | 公開日 | 2022-11-09 | | 最終更新日 | 2024-07-03 | | 実験手法 | ELECTRON MICROSCOPY (3.64 Å) | | 主引用文献 | Structural basis of TRPV3 inhibition by an antagonist.
Nat.Chem.Biol., 19, 2023
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7XJ1
 | | Structure of human TRPV3_G573S in complex with Trpvicin in C2 symmetry | | 分子名称: | Fusion protein of Transient receptor potential cation channel subfamily V member 3 and 3C-GFP, N-[5-[2-(2-cyanopropan-2-yl)pyridin-4-yl]-4-(trifluoromethyl)-1,3-thiazol-2-yl]-4,6-dimethoxy-pyrimidine-5-carboxamide, [(2~{R})-1-[2-azanylethoxy(oxidanyl)phosphoryl]oxy-3-hexadecanoyloxy-propan-2-yl] (~{Z})-octadec-9-enoate | | 著者 | Fan, J, Yue, Z, Jiang, D, Lei, X. | | 登録日 | 2022-04-14 | | 公開日 | 2022-11-09 | | 最終更新日 | 2024-07-03 | | 実験手法 | ELECTRON MICROSCOPY (2.93 Å) | | 主引用文献 | Structural basis of TRPV3 inhibition by an antagonist.
Nat.Chem.Biol., 19, 2023
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7XJ3
 | | Structure of human TRPV3 | | 分子名称: | [(2~{R})-1-[2-azanylethoxy(oxidanyl)phosphoryl]oxy-3-hexadecanoyloxy-propan-2-yl] (~{Z})-octadec-9-enoate, fusion of transient receptor potential cation channel subfamily V member 3 and 3C-GFP | | 著者 | Fan, J, Yue, Z, Jiang, D, Lei, X. | | 登録日 | 2022-04-14 | | 公開日 | 2022-11-09 | | 最終更新日 | 2024-07-03 | | 実験手法 | ELECTRON MICROSCOPY (3.54 Å) | | 主引用文献 | Structural basis of TRPV3 inhibition by an antagonist.
Nat.Chem.Biol., 19, 2023
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7XJ0
 | | Structure of human TRPV3 in complex with Trpvicin | | 分子名称: | Fusion protein of Transient receptor potential cation channel subfamily V member 3 and 3C-GFP, N-[5-[2-(2-cyanopropan-2-yl)pyridin-4-yl]-4-(trifluoromethyl)-1,3-thiazol-2-yl]-4,6-dimethoxy-pyrimidine-5-carboxamide, [(2~{R})-1-[2-azanylethoxy(oxidanyl)phosphoryl]oxy-3-hexadecanoyloxy-propan-2-yl] (~{Z})-octadec-9-enoate | | 著者 | Fan, J, Yue, Z, Jiang, D, Lei, X. | | 登録日 | 2022-04-14 | | 公開日 | 2022-11-09 | | 最終更新日 | 2023-01-11 | | 実験手法 | ELECTRON MICROSCOPY (2.53 Å) | | 主引用文献 | Structural basis of TRPV3 inhibition by an antagonist.
Nat.Chem.Biol., 19, 2023
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7RAS
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7RAU
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7X6C
 | | Cryo-EM structure of the human TRPC5 ion channel in lipid nanodiscs, class1 | | 分子名称: | (2S)-2-(hexadecanoyloxy)-3-hydroxypropyl (9Z)-octadec-9-enoate, (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, CALCIUM ION, ... | | 著者 | Won, J, Jeong, H, Lee, H.H. | | 登録日 | 2022-03-07 | | 公開日 | 2023-05-24 | | 実験手法 | ELECTRON MICROSCOPY (3.15 Å) | | 主引用文献 | Molecular architecture of the G alpha i -bound TRPC5 ion channel.
Nat Commun, 14, 2023
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7XUF
 | | Cryo-EM structure of the AKT1-AtKC1 complex from Arabidopsis thaliana | | 分子名称: | POTASSIUM ION, Potassium channel AKT1, Potassium channel KAT3 | | 著者 | Yang, G.H, Lu, Y.M, Jia, Y.T, Yang, F, Zhang, Y.M, Xu, X, Li, X.M, Lei, J.L. | | 登録日 | 2022-05-18 | | 公開日 | 2022-11-09 | | 最終更新日 | 2024-07-03 | | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | | 主引用文献 | Structural basis for the activity regulation of a potassium channel AKT1 from Arabidopsis.
Nat Commun, 13, 2022
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7RQZ
 | | Cryo-EM structure of the full-length TRPV1 with RTx at 48 degrees Celsius, in an open state, class alpha | | 分子名称: | 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine, Transient receptor potential cation channel subfamily V member 1, [(2~{R})-1-[2-azanylethoxy(oxidanyl)phosphoryl]oxy-3-hexadecanoyloxy-propan-2-yl] (~{Z})-octadec-9-enoate, ... | | 著者 | Kwon, D.H, Suo, Y, Lee, S.-Y. | | 登録日 | 2021-08-08 | | 公開日 | 2022-06-01 | | 実験手法 | ELECTRON MICROSCOPY (3.32 Å) | | 主引用文献 | Vanilloid-dependent TRPV1 opening trajectory from cryoEM ensemble analysis.
Nat Commun, 13, 2022
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7RQY
 | | Cryo-EM structure of the full-length TRPV1 with RTx at 25 degrees Celsius, in an open state, class B | | 分子名称: | 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine, Transient receptor potential cation channel subfamily V member 1, [(2~{R})-1-[2-azanylethoxy(oxidanyl)phosphoryl]oxy-3-hexadecanoyloxy-propan-2-yl] (~{Z})-octadec-9-enoate, ... | | 著者 | Kwon, D.H, Suo, Y, Lee, S.-Y. | | 登録日 | 2021-08-08 | | 公開日 | 2022-06-01 | | 実験手法 | ELECTRON MICROSCOPY (3.04 Å) | | 主引用文献 | Vanilloid-dependent TRPV1 opening trajectory from cryoEM ensemble analysis.
Nat Commun, 13, 2022
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7RQX
 | | Cryo-EM structure of the full-length TRPV1 with RTx at 25 degrees Celsius, in an intermediate-open state, class A | | 分子名称: | 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine, SODIUM ION, Transient receptor potential cation channel subfamily V member 1, ... | | 著者 | Kwon, D.H, Suo, Y, Lee, S.-Y. | | 登録日 | 2021-08-08 | | 公開日 | 2022-06-01 | | 実験手法 | ELECTRON MICROSCOPY (3.36 Å) | | 主引用文献 | Vanilloid-dependent TRPV1 opening trajectory from cryoEM ensemble analysis.
Nat Commun, 13, 2022
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7RQU
 | | Cryo-EM structure of the full-length TRPV1 with RTx at 4 degrees Celsius, in a closed state, class I | | 分子名称: | 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine, 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphoglycerol, SODIUM ION, ... | | 著者 | Kwon, D.H, Suo, Y, Lee, S.-Y. | | 登録日 | 2021-08-08 | | 公開日 | 2022-06-01 | | 実験手法 | ELECTRON MICROSCOPY (3.05 Å) | | 主引用文献 | Vanilloid-dependent TRPV1 opening trajectory from cryoEM ensemble analysis.
Nat Commun, 13, 2022
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7RQW
 | | Cryo-EM structure of the full-length TRPV1 with RTx at 4 degrees Celsius, in an open state, class III | | 分子名称: | 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine, Transient receptor potential cation channel subfamily V member 1, ... | | 著者 | Kwon, D.H, Suo, Y, Lee, S.-Y. | | 登録日 | 2021-08-08 | | 公開日 | 2022-06-01 | | 実験手法 | ELECTRON MICROSCOPY (3.11 Å) | | 主引用文献 | Vanilloid-dependent TRPV1 opening trajectory from cryoEM ensemble analysis.
Nat Commun, 13, 2022
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7RQV
 | | Cryo-EM structure of the full-length TRPV1 with RTx at 4 degrees Celsius, in an intermediate-closed state, class II | | 分子名称: | 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine, SODIUM ION, Transient receptor potential cation channel subfamily V member 1, ... | | 著者 | Kwon, D.H, Suo, Y, Lee, S.-Y. | | 登録日 | 2021-08-08 | | 公開日 | 2022-06-01 | | 実験手法 | ELECTRON MICROSCOPY (3.45 Å) | | 主引用文献 | Vanilloid-dependent TRPV1 opening trajectory from cryoEM ensemble analysis.
Nat Commun, 13, 2022
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7WM2
 | | Cryo-EM structure of AKT1 | | 分子名称: | (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, POTASSIUM ION, Potassium channel AKT1 | | 著者 | Dongliang, L, Zijie, Z, Yannan, Q, Yuyue, T, Huaizong, S. | | 登録日 | 2022-01-14 | | 公開日 | 2023-01-25 | | 最終更新日 | 2024-06-26 | | 実験手法 | ELECTRON MICROSCOPY (2.69 Å) | | 主引用文献 | Structural basis for the regulation mechanism of a hyperpolarization-activated K+ channel AKT1 by AtKC1
To Be Published
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7WM1
 | | Cryo-EM structure of AKT1-AtKC1 | | 分子名称: | (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, POTASSIUM ION, Potassium channel AKT1, ... | | 著者 | Dongliang, L, Zijie, Z, Yannan, Q, Yuyue, T, Huaizong, S. | | 登録日 | 2022-01-14 | | 公開日 | 2023-01-25 | | 最終更新日 | 2024-06-26 | | 実験手法 | ELECTRON MICROSCOPY (2.8 Å) | | 主引用文献 | Structural basis for the regulation mechanism of a hyper polarization-activated K+ channel AKT1 by AtKC1
To Be Published
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8JU5
 | | Structure of human TRPV4 with antagonist A1 | | 分子名称: | 4-[(3~{S},4~{S})-4-(aminomethyl)-1-(5-chloranylpyridin-2-yl)sulfonyl-4-oxidanyl-pyrrolidin-3-yl]oxy-2-fluoranyl-benzenecarbonitrile, Transient receptor potential cation channel subfamily V member 4,3C-GFP | | 著者 | Fan, J, Lei, X. | | 登録日 | 2023-06-24 | | 公開日 | 2024-05-08 | | 最終更新日 | 2024-07-24 | | 実験手法 | ELECTRON MICROSCOPY (3.74 Å) | | 主引用文献 | Structural Pharmacology of TRPV4 Antagonists.
Adv Sci, 11, 2024
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8JU6
 | | Structure of human TRPV4 with antagonist GSK279 | | 分子名称: | 1-({(5S,7S)-3-[5-(2-hydroxypropan-2-yl)pyrazin-2-yl]-7-methyl-2-oxo-1-oxa-3-azaspiro[4.5]decan-7-yl}methyl)-1H-benzimidazole-6-carbonitrile, Transient receptor potential cation channel subfamily V member 4,3C-GFP | | 著者 | Fan, J, Lei, X. | | 登録日 | 2023-06-24 | | 公開日 | 2024-05-08 | | 最終更新日 | 2024-07-24 | | 実験手法 | ELECTRON MICROSCOPY (3.45 Å) | | 主引用文献 | Structural Pharmacology of TRPV4 Antagonists.
Adv Sci, 11, 2024
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8JVI
 | | Structure of human TRPV4 with antagonist A2 | | 分子名称: | Transient receptor potential cation channel subfamily V member 4,3C-GFP, [6-[[4-(2,4-dimethyl-1,3-thiazol-5-yl)-1,3-thiazol-2-yl]amino]pyridin-3-yl]-[(1~{S},5~{R})-3-[5-(trifluoromethyl)pyrimidin-2-yl]-3,8-diazabicyclo[3.2.1]octan-8-yl]methanone | | 著者 | Fan, J, Lei, X. | | 登録日 | 2023-06-28 | | 公開日 | 2024-05-08 | | 最終更新日 | 2024-07-24 | | 実験手法 | ELECTRON MICROSCOPY (3.21 Å) | | 主引用文献 | Structural Pharmacology of TRPV4 Antagonists.
Adv Sci, 11, 2024
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8JVJ
 | | Structure of human TRPV4 with antagonist A2 and RhoA | | 分子名称: | Transforming protein RhoA, Transient receptor potential cation channel subfamily V member 4,3C-GFP, [6-[[4-(2,4-dimethyl-1,3-thiazol-5-yl)-1,3-thiazol-2-yl]amino]pyridin-3-yl]-[(1~{S},5~{R})-3-[5-(trifluoromethyl)pyrimidin-2-yl]-3,8-diazabicyclo[3.2.1]octan-8-yl]methanone | | 著者 | Fan, J, Lei, X. | | 登録日 | 2023-06-28 | | 公開日 | 2024-05-08 | | 最終更新日 | 2024-07-24 | | 実験手法 | ELECTRON MICROSCOPY (3.44 Å) | | 主引用文献 | Structural Pharmacology of TRPV4 Antagonists.
Adv Sci, 11, 2024
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7X6I
 | | Cryo-EM structure of the human TRPC5 ion channel in complex with G alpha i3 subunits, class1 | | 分子名称: | (2S)-2-(hexadecanoyloxy)-3-hydroxypropyl (9Z)-octadec-9-enoate, CALCIUM ION, CHOLESTEROL HEMISUCCINATE, ... | | 著者 | Won, J, Jeong, H, Lee, H.H. | | 登録日 | 2022-03-07 | | 公開日 | 2023-04-26 | | 最終更新日 | 2023-05-24 | | 実験手法 | ELECTRON MICROSCOPY (3.93 Å) | | 主引用文献 | Molecular architecture of the G alpha i -bound TRPC5 ion channel.
Nat Commun, 14, 2023
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7S89
 | | Open apo-state cryo-EM structure of human TRPV6 in cNW11 nanodiscs | | 分子名称: | (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, CALCIUM ION, ... | | 著者 | Neuberger, A, Nadezhdin, K.D, Sobolevsky, A.I. | | 登録日 | 2021-09-17 | | 公開日 | 2021-11-17 | | 最終更新日 | 2024-06-05 | | 実験手法 | ELECTRON MICROSCOPY (2.54 Å) | | 主引用文献 | Structural mechanisms of TRPV6 inhibition by ruthenium red and econazole.
Nat Commun, 12, 2021
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7S8C
 | | Cryo-EM structure of human TRPV6 in complex with inhibitor econazole | | 分子名称: | (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, 1-[(2R)-2-[(4-chlorobenzyl)oxy]-2-(2,4-dichlorophenyl)ethyl]-1H-imidazole, CALCIUM ION, ... | | 著者 | Neuberger, A, Nadezhdin, K.D, Sobolevsky, A.I. | | 登録日 | 2021-09-17 | | 公開日 | 2021-11-17 | | 最終更新日 | 2024-06-05 | | 実験手法 | ELECTRON MICROSCOPY (2.85 Å) | | 主引用文献 | Structural mechanisms of TRPV6 inhibition by ruthenium red and econazole.
Nat Commun, 12, 2021
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7S88
 | | Open apo-state cryo-EM structure of human TRPV6 in glyco-diosgenin detergent | | 分子名称: | (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, CALCIUM ION, ... | | 著者 | Neuberger, A, Nadezhdin, K.D, Sobolevsky, A.I. | | 登録日 | 2021-09-17 | | 公開日 | 2021-11-17 | | 最終更新日 | 2024-06-05 | | 実験手法 | ELECTRON MICROSCOPY (2.69 Å) | | 主引用文献 | Structural mechanisms of TRPV6 inhibition by ruthenium red and econazole.
Nat Commun, 12, 2021
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