7S88

Open apo-state cryo-EM structure of human TRPV6 in glyco-diosgenin detergent

Summary for 7S88

Entry DOI	10.2210/pdb7s88/pdb
EMDB information	24890
Descriptor	Transient receptor potential cation channel subfamily V member 6, CHOLESTEROL HEMISUCCINATE, 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, ... (6 entities in total)
Functional Keywords	transient receptor potential v family member 6, trp, channel, apo, open, human, trpv6, membrane protein
Biological source	Homo sapiens (Human)
Total number of polymer chains	4
Total formula weight	359630.95
Authors	Neuberger, A.,Nadezhdin, K.D.,Sobolevsky, A.I. (deposition date: 2021-09-17, release date: 2021-11-17, Last modification date: 2024-06-05)
Primary citation	Neuberger, A.,Nadezhdin, K.D.,Sobolevsky, A.I. Structural mechanisms of TRPV6 inhibition by ruthenium red and econazole. Nat Commun, 12:6284-6284, 2021 Cited by PubMed: 34725357 DOI: 10.1038/s41467-021-26608-x PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (2.69 Å)

Structure validation