7S88
Open apo-state cryo-EM structure of human TRPV6 in glyco-diosgenin detergent
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (A, B, C, D) | Transient receptor potential cation channel subfamily V member 6 | polymer | 683 | 78421.3 | 4 | UniProt (Q9H1D0) Pfam (PF12796) Pfam (PF00023) Pfam (PF00520) | Homo sapiens (Human) | TrpV6,CaT-like,CaT-L,Calcium transport protein 1,CaT1,Epithelial calcium channel 2,ECaC2 |
| 2 | E, F, FB, HB, IB... (A, D, C, B) | CHOLESTEROL HEMISUCCINATE | non-polymer | 486.7 | 12 | Chemie (Y01) PubChem (16219150) PubChem (22210610) PubChem (65082) PubChem (363416) PubChem (45489984) PubChem (500055) PubChem (60078761) PubChem (57163942) PubChem (73440805) PubChem (89891013) PubChem (13301926) PubChem (13301927) PubChem (99567469) PubChem (99567468) PubChem (124427194) PubChem (124897021) PubChem (124897020) PubChem (10005657) PubChem (130340716) PubChem (11969853) PubChem (124301053) PubChem (124302591) PubChem (124303794) PubChem (124421343) PubChem (124427195) PubChem (137392566) PubChem (137496323) PubChem (124914595) PubChem (124914596) PubChem (131705526) PubChem (155804219) PubChem (137332121) PubChem (137496357) PubChem (146157332) PubChem (169132514) PubChem (154929912) PubChem (155199678) PubChem (156327905) PubChem (156426247) PubChem (156516588) PubChem (166979870) PubChem (167024614) PubChem (169132513) PubChem (170117245) PubChem (172400028) | |||
| 3 | AB, DB, EB, FA, G... (C, D, B, A) | 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE | non-polymer | 787.1 | 20 | Chemie (PCW) | |||
| 4 | AA, BA, BB, CA, CB... (B, D, A, C) | (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate | non-polymer | 760.1 | 32 | Chemie (POV) PubChem (65167) PubChem (5497103) PubChem (6436017) PubChem (6506401) PubChem (168614) PubChem (10908846) PubChem (6070971) | |||
| 5 | U (A) | CALCIUM ION | non-polymer | 40.1 | 1 | Chemie (CA) PubChem (271) | |||
| 6 | RB, SB, TB, UB (A, B, C, D) | water | water | 18.0 | 144 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 1 - 667 (UniProt: Q9H1D0)
| PDB | External Database | Details |
|---|---|---|
| Val 668 | - | expression tag |
| Pro 669 | - | expression tag |
| Arg 670 | - | expression tag |
| Gly 671 | - | expression tag |
| Ser 672 | - | expression tag |
| Ala 673 | - | expression tag |
| Ala 674 | - | expression tag |
| Ala 675 | - | expression tag |
| Trp 676 | - | expression tag |
| Ser 677 | - | expression tag |
| His 678 | - | expression tag |
| Pro 679 | - | expression tag |
| Gln 680 | - | expression tag |
| Phe 681 | - | expression tag |
| Glu 682 | - | expression tag |
| Lys 683 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 313685.3 | |
| Non-Polymers* | Number of molecules | 65 |
| Total formula weight | 45945.6 | |
| All* | Total formula weight | 359631.0 |
