PDB: 594 件ウェブページステータス検索Chemie searchBIRD

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6WO2	Crystal Structure of the Grb2 SH2 Domain in Complex with a Tripeptide: Ac-pY-Ac6c-N-isohexyl 分子名称: ACE-PTR-02K-ASN-U67, CALCIUM ION, Growth factor receptor-bound protein 2, ... 著者 Martin, S.F, Clements, J.H. 登録日 2020-04-24 公開日 2020-09-02 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Some thermodynamic effects of varying nonpolar surfaces in protein-ligand interactions. Eur.J.Med.Chem., 208, 2020
7MPH	GRB2 SH2 Domain with Compound 7 分子名称: (4-{(10R,11E,14S,18S)-18-(2-amino-2-oxoethyl)-14-[(naphthalen-1-yl)methyl]-8,17,20-trioxo-7,16,19-triazaspiro[5.14]icos-11-en-10-yl}phenyl)acetic acid, 1,2-ETHANEDIOL, Growth factor receptor-bound protein 2, ... 著者 Sun, L, Schonbrunn, E. 登録日 2021-05-04 公開日 2021-09-22 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Synthesis and structural characterization of a monocarboxylic inhibitor for GRB2 SH2 domain. Bioorg.Med.Chem.Lett., 51, 2021
2IUH	Crystal structure of the PI3-kinase p85 N-terminal SH2 domain in complex with c-Kit phosphotyrosyl peptide 分子名称: C-KIT PHOSPHOTYROSYL PEPTIDE, PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY ALPHA SUBUNIT 著者 Nolte, R.T, Eck, M.J, Schlessinger, J, Shoelson, S.E, Harrison, S.C. 登録日 2006-06-03 公開日 2006-06-06 最終更新日 2021-04-28 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Crystal Structure of the Pi 3-Kinase P85 Amino-Terminal Sh2 Domain and its Phosphopeptide Complexes Nat.Struct.Biol., 3, 1996
1SHD	PEPTIDE INHIBITORS OF SRC SH3-SH2-PHOSPHOPROTEIN INTERACTIONS 分子名称: C-SRC TYROSINE KINASE SH2 DOMAIN, TRKA RECEPTOR 著者 Gilmer, T, Jordan, S. 登録日 1994-11-10 公開日 1995-01-26 最終更新日 2024-06-05 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Peptide inhibitors of src SH3-SH2-phosphoprotein interactions. J.Biol.Chem., 269, 1994
1O4E	CRYSTAL STRUCTURE OF SH2 IN COMPLEX WITH RU78299. 分子名称: 2,6-DIFORMYL-4-METHYLPHENYL DIHYDROGEN PHOSPHATE, PROTO-ONCOGENE TYROSINE-PROTEIN KINASE SRC 著者 Lange, G, Loenze, P, Liesum, A. 登録日 2003-06-15 公開日 2004-02-17 最終更新日 2023-08-16 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Requirements for specific binding of low affinity inhibitor fragments to the SH2 domain of (pp60)Src are identical to those for high affinity binding of full length inhibitors. J.Med.Chem., 46, 2003
3N8M	Crystal Structure of the Grb2 SH2 Domain in Complex with An Acyclic Ligand Having the Sequence pYVNVP 分子名称: GLYCEROL, Growth factor receptor-bound protein 2, PEPTIDE 著者 Whiddon, B.B, Clements, J.H, Martin, S.F. 登録日 2010-05-28 公開日 2010-12-15 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Thermodynamic and Structural Effects of Macrocyclization as a Constraining Method in Protein-Ligand Interactions. ACS MED.CHEM.LETT., 1, 2010
1A09	C-src (SH2 domain) complexed with ace-formyl phosphotyr-glu-(n,n-dipentyl amine) 分子名称: ACE-FORMYL PHOSPHOTYR-GLU-(N,N-DIPENTYL AMINE), C-SRC TYROSINE KINASE 著者 Shewchuk, L, Jordan, S. 登録日 1997-12-10 公開日 1998-04-08 最終更新日 2023-08-02 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Peptide ligands of pp60(c-src) SH2 domains: a thermodynamic and structural study. Biochemistry, 36, 1997
1QCF	CRYSTAL STRUCTURE OF HCK IN COMPLEX WITH A SRC FAMILY-SELECTIVE TYROSINE KINASE INHIBITOR 分子名称: 1-TER-BUTYL-3-P-TOLYL-1H-PYRAZOLO[3,4-D]PYRIMIDIN-4-YLAMINE, Tyrosine-protein kinase HCK 著者 Schindler, T, Sicheri, F, Pico, A, Gazit, A, Levitzki, A, Kuriyan, J. 登録日 1999-05-04 公開日 1999-06-08 最終更新日 2022-12-21 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Crystal structure of Hck in complex with a Src family-selective tyrosine kinase inhibitor. Mol.Cell, 3, 1999
2HDV	Crystal structure of the Src Homology-2 domain of the adapter protein SH2-B 分子名称: SH2-B PH domain containing signaling mediator 1 gamma isoform 著者 Hu, J, Hubbard, S.R. 登録日 2006-06-20 公開日 2006-08-08 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Structural Basis for Phosphotyrosine Recognition by the Src Homology-2 Domains of the Adapter Proteins SH2-B and APS. J.Mol.Biol., 361, 2006
2HMH	Crystal structure of SOCS3 in complex with gp130(pTyr757) phosphopeptide. 分子名称: Interleukin-6 receptor beta chain, Suppressor of cytokine signaling 3 著者 Bergamin, E, Wu, J, Hubbard, S.R. 登録日 2006-07-11 公開日 2006-08-15 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Structural basis for phosphotyrosine recognition by suppressor of cytokine signaling-3. Structure, 14, 2006
3N84	Crystal Structure of the Grb2 SH2 Domain in Complex with a 23-Membered Macrocyclic Ligand Having the Sequence pYVNVP 分子名称: 23-membered peptide-like macrocyclic ligand, CHLORIDE ION, GLYCEROL, ... 著者 Clements, J.H, Martin, S.F. 登録日 2010-05-27 公開日 2011-01-12 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Thermodynamic and Structural Effects of Macrocyclization as a Constraining Method in Protein-Ligand Interactions. ACS MED.CHEM.LETT., 1, 2010
1BKM	COCRYSTAL STRUCTURE OF D-AMINO ACID SUBSTITUTED PHOSPHOPEPTIDE COMPLEX 分子名称: PP60 V-SRC TYROSINE KINASE TRANSFORMING PROTEIN, [[O-PHOSPHONO-N-ACETYL-TYROSINYL]-GLUTAMYL-3[CYCLOHEXYLMETHYL]ALANINYL]-AMINE 著者 Holland, D.R, Rubin, J.R. 登録日 1997-05-02 公開日 1997-07-07 最終更新日 2024-05-22 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Structure-Based Design of a Novel Series of Nonpeptide Ligands that Bind to the Pp60Src Sh2 Domain J.Am.Chem.Soc., 119, 1997
7NUF	Vaccinia virus protein 018 in complex with STAT1 分子名称: ACETYL GROUP, SULFATE ION, Signal transducer and activator of transcription 1-alpha/beta, ... 著者 Pantelejevs, T, Talbot-Cooper, C, Smith, G.L, Hyvonen, M. 登録日 2021-03-12 公開日 2021-07-28 最終更新日 2024-02-07 実験手法 X-RAY DIFFRACTION (2.0004015 Å) 主引用文献 Poxviruses and paramyxoviruses use a conserved mechanism of STAT1 antagonism to inhibit interferon signaling. Cell Host Microbe, 30, 2022
3QWX	CED-2 1-174 分子名称: Cell death abnormality protein 2, SULFATE ION 著者 Kang, Y, Sun, J, Liu, Y. 登録日 2011-02-28 公開日 2011-06-08 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (2.01 Å) 主引用文献 Crystal structure of the cell corpse engulfment protein CED-2 in Caenorhabditis elegans. Biochem.Biophys.Res.Commun., 410, 2011
7ZLR	Crystal structure of SOCS2:ElonginB:ElonginC in complex with compound 13 分子名称: Elongin-B, Elongin-C, Suppressor of cytokine signaling 2, ... 著者 Ramachandran, S, Ciulli, A, Makukhin, N. 登録日 2022-04-15 公開日 2023-04-26 最終更新日 2024-05-01 実験手法 X-RAY DIFFRACTION (2.01 Å) 主引用文献 Structure-based design of a phosphotyrosine-masked covalent ligand targeting the E3 ligase SOCS2. Nat Commun, 14, 2023
3KFJ	Crystal Structure of the Grb2 SH2 Domain in Complex with a Flexible Ac-pY-E-N-NH2 Tripeptide Mimic 分子名称: CHLORIDE ION, Growth factor receptor-bound protein 2, MAGNESIUM ION, ... 著者 Clements, J.H. 登録日 2009-10-27 公開日 2010-03-02 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (2.02 Å) 主引用文献 Thermodynamic and structural effects of conformational constraints in protein-ligand interactions. Entropic paradoxy associated with ligand preorganization. J.Am.Chem.Soc., 131, 2009
3IMJ	Crystal Structure of the Grb2 SH2 Domain in Complex with a Cyclopropyl-constrained Ac-pTyr-Ile-Asn-NH2 Tripeptide Mimic 分子名称: (1R,2S,3R,1S',1S")Phosphoric acid mono(4-{2-[1-(1,2-dicarbamoylethylcarbamoyl)-3-carbamoylpropylcarbamoyl]-3-methylcarbamoylcyclopropyl}phenyl) ester, Growth factor receptor-bound protein 2 著者 Clements, J.H. 登録日 2009-08-10 公開日 2009-11-17 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (2.02 Å) 主引用文献 Thermodynamic and Structural Effects of Conformational Constraints in Protein-Ligand Interactions. Entropic Paradoxy Associated with Ligand Preorganization. J.Am.Chem.Soc., 131, 2009
8RZW	A fragment-based inhibitor of SHP2 分子名称: 3,5-bis(chloranyl)pyrazin-2-amine, Tyrosine-protein phosphatase non-receptor type 11 著者 Cleasby, A, Price, A. 登録日 2024-02-13 公開日 2024-03-20 最終更新日 2024-04-10 実験手法 X-RAY DIFFRACTION (2.02 Å) 主引用文献 Fragment-Based Discovery of Allosteric Inhibitors of SH2 Domain-Containing Protein Tyrosine Phosphatase-2 (SHP2). J.Med.Chem., 67, 2024
3N7Y	Crystal Structure of the Grb2 SH2 Domain in Complex with a 20-Membered Macrocyclic Ligand Having the Sequence pYVNV 分子名称: 20-membered peptide-like macrocyclic ligand, Growth factor receptor-bound protein 2 著者 Whiddon, B.B, Clements, J.H, Martin, S.F. 登録日 2010-05-27 公開日 2011-01-12 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (2.02 Å) 主引用文献 Thermodynamic and Structural Effects of Macrocyclization as a Constraining Method in Protein-Ligand Interactions. ACS MED.CHEM.LETT., 1, 2010
8U7W	Crystal structure of non-receptor protein tyrosine phosphatase SHP2 in complex with inhibitor compound 7 分子名称: 1-{6-[(2,3-dichlorophenyl)sulfanyl]pyrido[2,3-b]pyrazin-2-yl}-4-methylpiperidin-4-amine, Tyrosine-protein phosphatase non-receptor type 11 著者 Mou, T.C. 登録日 2023-09-15 公開日 2024-01-03 実験手法 X-RAY DIFFRACTION (2.05 Å) 主引用文献 Discovery of 5-Azaquinoxaline Derivatives as Potent and Orally Bioavailable Allosteric SHP2 Inhibitors. Acs Med.Chem.Lett., 14, 2023
1AYA	CRYSTAL STRUCTURES OF PEPTIDE COMPLEXES OF THE AMINO-TERMINAL SH2 DOMAIN OF THE SYP TYROSINE PHOSPHATASE 分子名称: PEPTIDE PDGFR-1009, PROTEIN-TYROSINE PHOSPHATASE SYP (N-TERMINAL SH2 DOMAIN) 著者 Lee, C.-H, Kuriyan, J. 登録日 1994-05-15 公開日 1994-08-31 最終更新日 2024-06-05 実験手法 X-RAY DIFFRACTION (2.05 Å) 主引用文献 Crystal structures of peptide complexes of the amino-terminal SH2 domain of the Syp tyrosine phosphatase. Structure, 2, 1994
6MDD	Non-receptor Protein Tyrosine Phosphatase SHP2 in Complex with Allosteric Inhibitor Imidazo-pyridine 24 分子名称: 5-[(2,3-dichlorophenyl)sulfanyl]-3H-imidazo[4,5-b]pyridin-2-amine, PHOSPHATE ION, Tyrosine-protein phosphatase non-receptor type 11 著者 Fodor, M, Stams, T. 登録日 2018-09-04 公開日 2019-02-13 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (2.05 Å) 主引用文献 Optimization of Fused Bicyclic Allosteric SHP2 Inhibitors. J. Med. Chem., 62, 2019
3TL0	Structure of SHP2 N-SH2 domain in complex with RLNpYAQLWHR peptide 分子名称: RLNpYAQLWHR peptide, SULFATE ION, Tyrosine-protein phosphatase non-receptor type 11 著者 Zhang, Y, Zhang, J, Yuan, C, Hard, R.L, Park, I.H, Li, C, Bell, C.E, Pei, D. 登録日 2011-08-29 公開日 2011-09-28 最終更新日 2023-12-06 実験手法 X-RAY DIFFRACTION (2.05 Å) 主引用文献 Simultaneous binding of two peptidyl ligands by a SRC homology 2 domain. Biochemistry, 50, 2011
6BMV	Non-receptor Protein Tyrosine Phosphatase SHP2 in Complex with Allosteric Inhibitor SHP504 分子名称: 3-{4-[(2-chlorophenyl)methyl]-5-oxo-4,5-dihydro[1,2,4]triazolo[4,3-a]quinazolin-1-yl}-4-hydroxybenzoic acid, PHOSPHATE ION, Tyrosine-protein phosphatase non-receptor type 11 著者 Stams, T, Fodor, M. 登録日 2017-11-15 公開日 2018-01-17 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (2.053 Å) 主引用文献 Dual Allosteric Inhibition of SHP2 Phosphatase. ACS Chem. Biol., 13, 2018
9BLG	Crystal structure of non-receptor protein tyrosine phosphatase SHP2 in complex with PF-07284892 分子名称: (1S)-1'-{6-[(2-amino-3-chloropyridin-4-yl)sulfanyl]-1,2,4-triazin-3-yl}-1,3-dihydrospiro[indene-2,4'-piperidin]-1-amine, Tyrosine-protein phosphatase non-receptor type 11 著者 Bester, S.M, Wu, W.-I, Mou, T.-C. 登録日 2024-04-30 公開日 2024-05-29 実験手法 X-RAY DIFFRACTION (2.06 Å) 主引用文献 SHP2 Inhibition Sensitizes Diverse Oncogene-Addicted Solid Tumors to Re-treatment with Targeted Therapy. Cancer Discov, 13, 2023

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