9BLG

Crystal structure of non-receptor protein tyrosine phosphatase SHP2 in complex with PF-07284892

This is a non-PDB format compatible entry.

Summary for 9BLG

• Entry DOI: 10.2210/pdb9blg/pdb
• Descriptor: Tyrosine-protein phosphatase non-receptor type 11, (1S)-1'-{6-[(2-amino-3-chloropyridin-4-yl)sulfanyl]-1,2,4-triazin-3-yl}-1,3-dihydrospiro[indene-2,4'-piperidin]-1-amine (3 entities in total)
• Functional Keywords: phosphatase, inhibitor, shp2, hydrolase, hydrolase-inhibitor complex, hydrolase/inhibitor
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 2
• Total formula weight: 125059.87

Authors

Bester, S.M.,Wu, W.-I.,Mou, T.-C. (deposition date: 2024-04-30, release date: 2024-05-29)

• Primary citation: Drilon, A.,Sharma, M.R.,Johnson, M.L.,Yap, T.A.,Gadgeel, S.,Nepert, D.,Feng, G.,Reddy, M.B.,Harney, A.S.,Elsayed, M.,Cook, A.W.,Wong, C.E.,Hinklin, R.J.,Jiang, Y.,Brown, E.N.,Neitzel, N.A.,Laird, E.R.,Wu, W.I.,Singh, A.,Wei, P.,Ching, K.A.,Gaudino, J.J.,Lee, P.A.,Hartley, D.P.,Rothenberg, S.M.; SHP2 Inhibition Sensitizes Diverse Oncogene-Addicted Solid Tumors to Re-treatment with Targeted Therapy.; Cancer Discov, 13:1789-1801, 2023; PubMed: 37269335; DOI: 10.1158/2159-8290.CD-23-0361

Experimental method

X-RAY DIFFRACTION (2.06 Å)