9BLG

Crystal structure of non-receptor protein tyrosine phosphatase SHP2 in complex with PF-07284892

This is a non-PDB format compatible entry.

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	Tyrosine-protein phosphatase non-receptor type 11	polymer	539	62090.0	2	UniProt (Q06124) Pfam (PF00017) Pfam (PF00102)	Homo sapiens (human)
2	C, D (A, B)	(1S)-1'-{6-[(2-amino-3-chloropyridin-4-yl)sulfanyl]-1,2,4-triazin-3-yl}-1,3-dihydrospiro[indene-2,4'-piperidin]-1-amine	non-polymer		440.0	2	Chemie (A1AQ1)
3	E, F (A, B)	water	water		18.0	480	Chemie (HOH)

Sequence modifications

A, B: 1 - 525 (UniProt: Q06124)

PDB	External Database	Details
Met -13	-	initiating methionine
His -12	-	expression tag
His -11	-	expression tag
His -10	-	expression tag
His -9	-	expression tag
His -8	-	expression tag
His -7	-	expression tag
Glu -6	-	expression tag
Asn -5	-	expression tag
Leu -4	-	expression tag
Tyr -3	-	expression tag
Phe -2	-	expression tag
Gln -1	-	expression tag
Ser 0	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	124179.9
Non-Polymers*	Number of molecules	2
	Total formula weight	879.9
All*	Total formula weight	125059.9

*Water molecules are not included.