8U7W
Crystal structure of non-receptor protein tyrosine phosphatase SHP2 in complex with inhibitor compound 7
Summary for 8U7W
Entry DOI | 10.2210/pdb8u7w/pdb |
Descriptor | Tyrosine-protein phosphatase non-receptor type 11, 1-{6-[(2,3-dichlorophenyl)sulfanyl]pyrido[2,3-b]pyrazin-2-yl}-4-methylpiperidin-4-amine (3 entities in total) |
Functional Keywords | phosphatase, inhibitor, shp2, hydrolase, hydrolase-inhibitor complex, hydrolase/inhibitor |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 2 |
Total formula weight | 125020.66 |
Authors | |
Primary citation | Elsayed, M.S.A.,Blake, J.F.,Boys, M.L.,Brown, E.,Chapsal, B.D.,Chicarelli, M.J.,Cook, A.W.,Fell, J.B.,Fischer, J.P.,Hanson, L.,Lemieux, C.,Martinson, M.C.,McCown, J.,McNulty, O.T.,Mejia, M.J.,Neitzel, N.A.,Otten, J.N.,Rodriguez, M.E.,Wilcox, D.,Wong, C.E.,Zhou, Y.,Hinklin, R.J. Discovery of 5-Azaquinoxaline Derivatives as Potent and Orally Bioavailable Allosteric SHP2 Inhibitors. Acs Med.Chem.Lett., 14:1673-1681, 2023 Cited by PubMed: 38116446DOI: 10.1021/acsmedchemlett.3c00310 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.05 Å) |
Structure validation
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