PDB: 22634 件ウェブページステータス検索Chemie searchBIRD

---

1SFR	Crystal Structure of the Mycobacterium tuberculosis Antigen 85A Protein 分子名称: Antigen 85-A 著者 Ronning, D.R, Vissa, V, Besra, G.S, Belisle, J.T, Sacchettini, J.C, TB Structural Genomics Consortium (TBSGC) 登録日 2004-02-20 公開日 2004-07-06 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (2.7 Å) 主引用文献 Mycobacterium tuberculosis Antigen 85A and 85C Structures Confirm Binding Orientation and Conserved Substrate Specificity J.Biol.Chem., 279, 2004
4KM0	Crystal structure of dihydrofolate reductase from Mycobacterium tuberculosis in complex with pyrimethamine 分子名称: 2'-MONOPHOSPHOADENOSINE-5'-DIPHOSPHATE, 5-(4-CHLORO-PHENYL)-6-ETHYL-PYRIMIDINE-2,4-DIAMINE, Dihydrofolate reductase 著者 Dias, M.V.B, Tyrakis, P, Blundell, T.L. 登録日 2013-05-07 公開日 2013-12-25 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (1.3 Å) 主引用文献 Mycobacterium tuberculosis Dihydrofolate Reductase Reveals Two Conformational States and a Possible Low Affinity Mechanism to Antifolate Drugs. Structure, 22, 2014
4KLX	Crystal structure of dihydrofolate reductase from Mycobacterium tuberculosis in an open conformation. 分子名称: 2'-MONOPHOSPHOADENOSINE-5'-DIPHOSPHATE, 2-{2-[2-2-(METHOXY-ETHOXY)-ETHOXY]-ETHOXY}-ETHANOL, Dihydrofolate reductase 著者 Dias, M.V.B, Tyrakis, P, Blundell, T.L. 登録日 2013-05-07 公開日 2013-12-25 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (1.23 Å) 主引用文献 Mycobacterium tuberculosis Dihydrofolate Reductase Reveals Two Conformational States and a Possible Low Affinity Mechanism to Antifolate Drugs. Structure, 22, 2014
4KNE	Crystal structure of dihydrofolate reductase from Mycobacterium tuberculosis in complex with cycloguanil 分子名称: 1-(4-chlorophenyl)-6,6-dimethyl-1,6-dihydro-1,3,5-triazine-2,4-diamine, 2'-MONOPHOSPHOADENOSINE-5'-DIPHOSPHATE, Dihydrofolate reductase 著者 Dias, M.V.B, Tyrakis, P, Blundell, T.L. 登録日 2013-05-09 公開日 2013-12-25 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Mycobacterium tuberculosis Dihydrofolate Reductase Reveals Two Conformational States and a Possible Low Affinity Mechanism to Antifolate Drugs. Structure, 22, 2014
5H8U	Crystal structure of mycobacterium tuberculosis wild-type malate synthase in complex with product malate 分子名称: (2S)-2-hydroxybutanedioic acid, GLYOXYLIC ACID, MAGNESIUM ION, ... 著者 Krieger, I.V, Huang, H.-L, Sacchettini, J.C. 登録日 2015-12-23 公開日 2016-10-26 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (2.85 Å) 主引用文献 Mycobacterium tuberculosis Malate Synthase Structures with Fragments Reveal a Portal for Substrate/Product Exchange. J. Biol. Chem., 291, 2016
3MH9	Crystal structure of LprG mutant V91W from Mycobacterium tuberculosis 分子名称: Lipoprotein lprG 著者 Tsai, H.-C, Sacchettini, J.C, TB Structural Genomics Consortium (TBSGC) 登録日 2010-04-07 公開日 2010-09-01 最終更新日 2024-04-03 実験手法 X-RAY DIFFRACTION (1.794 Å) 主引用文献 Mycobacterium tuberculosis lipoprotein LprG (Rv1411c) binds triacylated glycolipid agonists of Toll-like receptor 2. Nat.Struct.Mol.Biol., 17, 2010
3MH8	Crystal structure of LprG from Mycobacterium tuberculosis 分子名称: Lipoprotein lprG 著者 Tsai, H.-C, Sacchettini, J.C, TB Structural Genomics Consortium (TBSGC) 登録日 2010-04-07 公開日 2010-09-01 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (1.995 Å) 主引用文献 Mycobacterium tuberculosis lipoprotein LprG (Rv1411c) binds triacylated glycolipid agonists of Toll-like receptor 2. Nat.Struct.Mol.Biol., 17, 2010
8QKK	Cryo-EM structure of MmpL3 from Mycobacterium smegmatis reconstituted into peptidiscs 分子名称: Trehalose monomycolate exporter MmpL3 著者 Couston, J, Guo, Z, Wang, K, Gourdon, P.E, Blaise, M. 登録日 2023-09-15 公開日 2023-11-15 最終更新日 2023-12-13 実験手法 ELECTRON MICROSCOPY (3.23 Å) 主引用文献 Cryo-EM structure of the trehalose monomycolate transporter, MmpL3, reconstituted into peptidiscs. Curr Res Struct Biol, 6, 2023
3OXH	Mycobacterium tuberculosis kinase inhibitor homolog RV0577 分子名称: CHLORIDE ION, PARA-MERCURY-BENZENESULFONIC ACID, RV0577 PROTEIN, ... 著者 Echols, N, Flynn, E.M, Stephenson, S, Ng, H.-L, Alber, T, TB Structural Genomics Consortium (TBSGC) 登録日 2010-09-21 公開日 2011-10-19 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (1.75 Å) 主引用文献 Structural and Biophysical Characterization of the Mycobacterium tuberculosis Protein Rv0577, a Protein Associated with Neutral Red Staining of Virulent Tuberculosis Strains and Homologue of the Streptomyces coelicolor Protein KbpA. Biochemistry, 2017
5T8G	Crystal structure of Mycobacterium tuberculosis malate synthase in complex with 2-oxo-4-((thiophene-2-carbonyl)oxy)butanoic acid 分子名称: (3E)-2-oxo-4-[(thiophen-2-ylcarbonyl)oxy]but-3-enoic acid, MAGNESIUM ION, Malate synthase G 著者 Huang, H.-L, Sacchetiini, J.C. 登録日 2016-09-07 公開日 2016-10-26 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (2.04 Å) 主引用文献 Mycobacterium tuberculosis Malate Synthase Structures with Fragments Reveal a Portal for Substrate/Product Exchange. J. Biol. Chem., 291, 2016
5JA3	Mycobacterium tuberculosis Dihydrofolate Reductase complexed with beta- NADPH and 3'-(3-(2,4-diamino-6-ethylpyrimidin-5-yl)prop-2-yn-1-yl)-4'-methoxy-[1,1'-b iphenyl]-4-carboxylic acid (UCP1106) 分子名称: 4-[3-[3-[2,4-bis(azanyl)-6-ethyl-pyrimidin-5-yl]prop-2-ynyl]-4-methoxy-phenyl]benzoic acid, Dihydrofolate reductase, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE 著者 Hajian, B, Anderson, A.C. 登録日 2016-04-11 公開日 2016-08-24 最終更新日 2024-03-06 実験手法 X-RAY DIFFRACTION (1.814 Å) 主引用文献 Propargyl-Linked Antifolates Are Potent Inhibitors of Drug-Sensitive and Drug-Resistant Mycobacterium tuberculosis. Plos One, 11, 2016
5KWA	complete structure of the Mycobacterium tuberculosis proteasomal ATPase Mpa 分子名称: ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, Proteasome-associated ATPase 著者 Wang, T, WU, Y.J. 登録日 2016-07-17 公開日 2017-06-07 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (2.9 Å) 主引用文献 Mycobacterium tuberculosis proteasomal ATPase Mpa has a beta-grasp domain that hinders docking with the proteasome core protease Mol. Microbiol., 105, 2017
1IDR	CRYSTAL STRUCTURE OF THE TRUNCATED-HEMOGLOBIN-N FROM MYCOBACTERIUM TUBERCULOSIS 分子名称: HEMOGLOBIN HBN, OXYGEN MOLECULE, PHOSPHATE ION, ... 著者 Milani, M, Pesce, A, Ascenzi, P, Guertin, M, Bolognesi, M. 登録日 2001-04-05 公開日 2001-08-22 最終更新日 2024-02-07 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Mycobacterium tuberculosis hemoglobin N displays a protein tunnel suited for O2 diffusion to the heme. EMBO J., 20, 2001
6GEO	Crystal structure of Mycobacterium tuberculosis cytochrome P450 CYP121A1 in complex with Triazole Pyrazole inhibitor 10j 分子名称: 2-chloranyl-3-[4-(imidazol-1-ylmethyl)-1-phenyl-pyrazol-3-yl]-1~{H}-indole, Mycocyclosin synthase, PROTOPORPHYRIN IX CONTAINING FE, ... 著者 Levy, C.W. 登録日 2018-04-27 公開日 2019-08-07 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (1.5 Å) 主引用文献 Design and Synthesis of Imidazole and Triazole Pyrazoles asMycobacterium TuberculosisCYP121A1 Inhibitors. Chemistryopen, 8, 2019
6GEQ	Crystal structure of Mycobacterium tuberculosis cytochrome P450 CYP121A1 in complex with Triazole Pyrazole inhibitor 14a 分子名称: 1-phenyl-3-pyridin-4-yl-~{N}-(pyridin-4-ylmethyl)pyrazole-4-carboxamide, Mycocyclosin synthase, PROTOPORPHYRIN IX CONTAINING FE, ... 著者 Levy, C.W. 登録日 2018-04-27 公開日 2019-08-07 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (1.6 Å) 主引用文献 Design and Synthesis of Imidazole and Triazole Pyrazoles asMycobacterium TuberculosisCYP121A1 Inhibitors. Chemistryopen, 8, 2019
4Y0L	Mycobacterial membrane protein MmpL11D2 分子名称: IODIDE ION, Putative membrane protein mmpL11, SULFATE ION 著者 Torres, R, Chim, N, Goulding, C.W. 登録日 2015-02-06 公開日 2015-08-12 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 The Structure and Interactions of Periplasmic Domains of Crucial MmpL Membrane Proteins from Mycobacterium tuberculosis. Chem.Biol., 22, 2015
6C67	Mycobacterium tuberculosis adenosine kinase bound to iodotubercidin 分子名称: (2R,3R,4S,5R)-2-(4-AMINO-5-IODO-7H-PYRROLO[2,3-D]PYRIMIDIN-7-YL)-5-(HYDROXYMETHYL)TETRAHYDROFURAN-3,4-DIOL, Adenosine kinase, GLYCEROL, ... 著者 Crespo, R.A, TB Structural Genomics Consortium (TBSGC) 登録日 2018-01-17 公開日 2019-05-01 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (2.11 Å) 主引用文献 Structure-Guided Drug Design of 6-Substituted Adenosine Analogues as Potent Inhibitors of Mycobacterium tuberculosis Adenosine Kinase. J.Med.Chem., 62, 2019
6CN8	High-resolution structure of ClpC1-NTD binding to Rufomycin-I 分子名称: ATP-dependent Clp protease ATP-binding subunit ClpC1, CHLORIDE ION, PHOSPHATE ION, ... 著者 Abad-Zapatero, C, Wolf, N.W. 登録日 2018-03-07 公開日 2019-06-05 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (1.4 Å) 主引用文献 High-Resolution Structure of ClpC1-Rufomycin and Ligand Binding Studies Provide a Framework to Design and Optimize Anti-Tuberculosis Leads. Acs Infect Dis., 5, 2019
5E57	Crystal structure of Mycobacterium smegmatis AmtR 分子名称: ACETATE ION, Transcription regulator AmtR 著者 Vickers, C.J, McKenzie, J.L, Arcus, V.L. 登録日 2015-10-07 公開日 2016-09-28 最終更新日 2024-03-06 実験手法 X-RAY DIFFRACTION (1.98 Å) 主引用文献 Structure and Function of AmtR in Mycobacterium smegmatis: Implications for Post-Transcriptional Regulation of Urea Metabolism through a Small Antisense RNA. J.Mol.Biol., 428, 2016
5ZVJ	Crystal structure of HtrA1 from Mycobacterium tuberculosis 分子名称: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, Serine protease 著者 Khundrakpam, H.S, Yadav, S, Kumar, D, Biswal, B.K. 登録日 2018-05-10 公開日 2018-09-05 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (2.7 Å) 主引用文献 The crystal structure of an essential high-temperature requirement protein HtrA1 (Rv1223) from Mycobacterium tuberculosis reveals its unique features. Acta Crystallogr D Struct Biol, 74, 2018
5CYY	Structure of the C-terminal domains of DipZ from Mycobacterium tuberculosis 分子名称: Protein DipZ 著者 Goldstone, D.C, Metcalf, P, Baker, E.N, Mycobacterium Tuberculosis Structural Proteomics Project (XMTB) 登録日 2015-07-31 公開日 2016-01-13 最終更新日 2018-04-18 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Structure of the ectodomain of the electron transporter Rv2874 from Mycobacterium tuberculosis reveals a thioredoxin-like domain combined with a carbohydrate-binding module. Acta Crystallogr D Struct Biol, 72, 2016
6J72	Crystal structure of IniA from Mycobacterium smegmatis with GTP bound 分子名称: GUANOSINE-5'-TRIPHOSPHATE, Isoniazid inducible gene protein IniA, L(+)-TARTARIC ACID, ... 著者 Wang, M.F, Guo, X.Y, Hu, J.J, Li, J, Rao, Z.H. 登録日 2019-01-16 公開日 2019-09-11 最終更新日 2024-03-27 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Mycobacterial dynamin-like protein IniA mediates membrane fission. Nat Commun, 10, 2019
7E1V	Cryo-EM structure of apo hybrid respiratory supercomplex consisting of Mycobacterium tuberculosis complexIII and Mycobacterium smegmatis complexIV 分子名称: (2R)-2-(hexadecanoyloxy)-3-{[(S)-hydroxy{[(1R,2R,3R,4R,5R,6S)-2,3,4,5,6-pentahydroxycyclohexyl]oxy}phosphoryl]oxy}propyl (9S)-9-methyloctadecanoate, (2R)-3-(((2-aminoethoxy)(hydroxy)phosphoryl)oxy)-2-(palmitoyloxy)propyl (E)-octadec-9-enoate, CARDIOLIPIN, ... 著者 Zhou, S, Wang, W, Gao, Y, Gong, H, Rao, Z. 登録日 2021-02-03 公開日 2021-10-13 最終更新日 2022-07-27 実験手法 ELECTRON MICROSCOPY (2.68 Å) 主引用文献 Structure of Mycobacterium tuberculosis cytochrome bcc in complex with Q203 and TB47, two anti-TB drug candidates. Elife, 10, 2021
7E1X	Cryo-EM structure of hybrid respiratory supercomplex consisting of Mycobacterium tuberculosis complexIII and Mycobacterium smegmatis complexIV in presence of TB47 分子名称: (2R)-2-(hexadecanoyloxy)-3-{[(S)-hydroxy{[(1R,2R,3R,4R,5R,6S)-2,3,4,5,6-pentahydroxycyclohexyl]oxy}phosphoryl]oxy}propyl (9S)-9-methyloctadecanoate, (2R)-3-(((2-aminoethoxy)(hydroxy)phosphoryl)oxy)-2-(palmitoyloxy)propyl (E)-octadec-9-enoate, 5-methoxy-2-methyl-~{N}-[[4-[4-[4-(trifluoromethyloxy)phenyl]piperidin-1-yl]phenyl]methyl]pyrazolo[1,5-a]pyridine-3-carboxamide, ... 著者 Zhou, S, Wang, W, Gao, Y, Gong, H, Rao, Z. 登録日 2021-02-03 公開日 2021-10-27 最終更新日 2022-07-27 実験手法 ELECTRON MICROSCOPY (2.93 Å) 主引用文献 Structure of Mycobacterium tuberculosis cytochrome bcc in complex with Q203 and TB47, two anti-TB drug candidates. Elife, 10, 2021
7E1W	Cryo-EM structure of hybrid respiratory supercomplex consisting of Mycobacterium tuberculosis complexIII and Mycobacterium smegmatis complexIV in the presence of Q203 分子名称: (2R)-2-(hexadecanoyloxy)-3-{[(S)-hydroxy{[(1R,2R,3R,4R,5R,6S)-2,3,4,5,6-pentahydroxycyclohexyl]oxy}phosphoryl]oxy}propyl (9S)-9-methyloctadecanoate, (2R)-3-(((2-aminoethoxy)(hydroxy)phosphoryl)oxy)-2-(palmitoyloxy)propyl (E)-octadec-9-enoate, 6-chloranyl-2-ethyl-N-[[4-[4-[4-(trifluoromethyloxy)phenyl]piperidin-1-yl]phenyl]methyl]imidazo[1,2-a]pyridine-3-carboxamide, ... 著者 Zhou, S, Wang, W, Gao, Y, Gong, H, Rao, Z. 登録日 2021-02-03 公開日 2021-10-27 最終更新日 2024-10-16 実験手法 ELECTRON MICROSCOPY (2.67 Å) 主引用文献 Structure of Mycobacterium tuberculosis cytochrome bcc in complex with Q203 and TB47, two anti-TB drug candidates. Elife, 10, 2021

<12345678910111213141516>