4KM0
Crystal structure of dihydrofolate reductase from Mycobacterium tuberculosis in complex with pyrimethamine
Summary for 4KM0
| Entry DOI | 10.2210/pdb4km0/pdb |
| Related | 4KL9 4KLX 4KM2 4KNE |
| Descriptor | Dihydrofolate reductase, 5-(4-CHLORO-PHENYL)-6-ETHYL-PYRIMIDINE-2,4-DIAMINE, 2'-MONOPHOSPHOADENOSINE-5'-DIPHOSPHATE, ... (4 entities in total) |
| Functional Keywords | reductase, oxidoreductase |
| Biological source | Mycobacterium tuberculosis |
| Total number of polymer chains | 2 |
| Total formula weight | 41176.51 |
| Authors | Dias, M.V.B.,Tyrakis, P.,Blundell, T.L. (deposition date: 2013-05-07, release date: 2013-12-25, Last modification date: 2024-02-28) |
| Primary citation | Dias, M.V.,Tyrakis, P.,Domingues, R.R.,Paes Leme, A.F.,Blundell, T.L. Mycobacterium tuberculosis Dihydrofolate Reductase Reveals Two Conformational States and a Possible Low Affinity Mechanism to Antifolate Drugs. Structure, 22:94-103, 2014 Cited by PubMed: 24210757DOI: 10.1016/j.str.2013.09.022 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.3 Å) |
Structure validation
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