5H8U

Crystal structure of mycobacterium tuberculosis wild-type malate synthase in complex with product malate

Summary for 5H8U

Related5H8M 5H8P
DescriptorMalate synthase G, MAGNESIUM ION, (2S)-2-hydroxybutanedioic acid, ... (5 entities in total)
Functional Keywordstransferase
Biological sourceMycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Cellular locationCytoplasm  P9WK17
Total number of polymer chains2
Total molecular weight161258.63
Authors
Krieger, I.V.,Huang, H.-L.,Sacchettini, J.C. (deposition date: 2015-12-23, release date: 2016-10-26, Last modification date: 2017-09-27)
Primary citation
Huang, H.L.,Krieger, I.V.,Parai, M.K.,Gawandi, V.B.,Sacchettini, J.C.
Mycobacterium tuberculosis Malate Synthase Structures with Fragments Reveal a Portal for Substrate/Product Exchange.
J. Biol. Chem., 291:27421-27432, 2016
PubMed: 27738104 (PDB entries with the same primary citation)
DOI: 10.1074/jbc.M116.750877
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (2.85 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.27661.3%3.9%3.3%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution