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5H8U

Crystal structure of mycobacterium tuberculosis wild-type malate synthase in complex with product malate

Functional Information from GO Data
ChainGOidnamespacecontents
A0000287molecular_functionmagnesium ion binding
A0001968molecular_functionfibronectin binding
A0003824molecular_functioncatalytic activity
A0004474molecular_functionmalate synthase activity
A0005515molecular_functionprotein binding
A0005518molecular_functioncollagen binding
A0005576cellular_componentextracellular region
A0005737cellular_componentcytoplasm
A0005829cellular_componentcytosol
A0005886cellular_componentplasma membrane
A0006097biological_processglyoxylate cycle
A0006099biological_processtricarboxylic acid cycle
A0009274cellular_componentpeptidoglycan-based cell wall
A0009436biological_processglyoxylate catabolic process
A0009986cellular_componentcell surface
A0015936biological_processcoenzyme A metabolic process
A0016740molecular_functiontransferase activity
A0042603cellular_componentcapsule
A0042803molecular_functionprotein homodimerization activity
A0043236molecular_functionlaminin binding
A0044406biological_processadhesion of symbiont to host
A0046810molecular_functionhost cell extracellular matrix binding
A0046872molecular_functionmetal ion binding
A0120225molecular_functioncoenzyme A binding
B0000287molecular_functionmagnesium ion binding
B0001968molecular_functionfibronectin binding
B0003824molecular_functioncatalytic activity
B0004474molecular_functionmalate synthase activity
B0005515molecular_functionprotein binding
B0005518molecular_functioncollagen binding
B0005576cellular_componentextracellular region
B0005737cellular_componentcytoplasm
B0005829cellular_componentcytosol
B0005886cellular_componentplasma membrane
B0006097biological_processglyoxylate cycle
B0006099biological_processtricarboxylic acid cycle
B0009274cellular_componentpeptidoglycan-based cell wall
B0009436biological_processglyoxylate catabolic process
B0009986cellular_componentcell surface
B0015936biological_processcoenzyme A metabolic process
B0016740molecular_functiontransferase activity
B0042603cellular_componentcapsule
B0042803molecular_functionprotein homodimerization activity
B0043236molecular_functionlaminin binding
B0044406biological_processadhesion of symbiont to host
B0046810molecular_functionhost cell extracellular matrix binding
B0046872molecular_functionmetal ion binding
B0120225molecular_functioncoenzyme A binding
Functional Information from PDB Data
site_idAC1
Number of Residues4
Detailsbinding site for residue MG A 801
ChainResidue
AGLU434
AASP462
ALMR802
AHOH917

site_idAC2
Number of Residues12
Detailsbinding site for residue LMR A 802
ChainResidue
ALEU461
AASP462
ATRP541
AASP633
AALA635
AMG801
AHOH912
AASP274
AARG339
AGLU434
AGLY459
APHE460

site_idAC3
Number of Residues5
Detailsbinding site for residue MG B 801
ChainResidue
BGLU434
BASP462
BGLV803
BHOH903
BHOH917

site_idAC4
Number of Residues4
Detailsbinding site for residue MG B 802
ChainResidue
AGLN557
AHOH926
BARG69
BHOH920

site_idAC5
Number of Residues10
Detailsbinding site for residue GLV B 803
ChainResidue
BASP274
BARG339
BGLU434
BGLY459
BPHE460
BLEU461
BASP462
BTRP541
BMG801
BHOH903

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues2
DetailsACT_SITE: Proton acceptor
ChainResidueDetails
AARG339
BARG339

site_idSWS_FT_FI2
Number of Residues2
DetailsACT_SITE: Proton donor
ChainResidueDetails
AASP633
BASP633

site_idSWS_FT_FI3
Number of Residues24
DetailsBINDING:
ChainResidueDetails
AARG312
AARG339
AGLU434
AGLY459
AASP462
APRO543
AGLY618
AASP633
BVAL118
BARG125
BSER275
BLYS305
BARG312
BARG339
BGLU434
BGLY459
BASP462
BPRO543
BGLY618
BASP633
AVAL118
AARG125
ASER275
ALYS305

site_idSWS_FT_FI4
Number of Residues2
DetailsMOD_RES: Cysteine sulfenic acid (-SOH) => ECO:0000255|HAMAP-Rule:MF_00641
ChainResidueDetails
ACYS619
BCYS619

218500

PDB entries from 2024-04-17

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