5H8U

Crystal structure of mycobacterium tuberculosis wild-type malate synthase in complex with product malate

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000287	molecular_function	magnesium ion binding
A	0001968	molecular_function	fibronectin binding
A	0003824	molecular_function	catalytic activity
A	0004474	molecular_function	malate synthase activity
A	0005515	molecular_function	protein binding
A	0005518	molecular_function	collagen binding
A	0005576	cellular_component	extracellular region
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0005886	cellular_component	plasma membrane
A	0006097	biological_process	glyoxylate cycle
A	0006099	biological_process	tricarboxylic acid cycle
A	0009274	cellular_component	peptidoglycan-based cell wall
A	0009436	biological_process	glyoxylate catabolic process
A	0009986	cellular_component	cell surface
A	0015936	biological_process	coenzyme A metabolic process
A	0016740	molecular_function	transferase activity
A	0042603	cellular_component	capsule
A	0042803	molecular_function	protein homodimerization activity
A	0043236	molecular_function	laminin binding
A	0044406	biological_process	adhesion of symbiont to host
A	0046810	molecular_function	host cell extracellular matrix binding
A	0046872	molecular_function	metal ion binding
A	0120225	molecular_function	coenzyme A binding
B	0000287	molecular_function	magnesium ion binding
B	0001968	molecular_function	fibronectin binding
B	0003824	molecular_function	catalytic activity
B	0004474	molecular_function	malate synthase activity
B	0005515	molecular_function	protein binding
B	0005518	molecular_function	collagen binding
B	0005576	cellular_component	extracellular region
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0005886	cellular_component	plasma membrane
B	0006097	biological_process	glyoxylate cycle
B	0006099	biological_process	tricarboxylic acid cycle
B	0009274	cellular_component	peptidoglycan-based cell wall
B	0009436	biological_process	glyoxylate catabolic process
B	0009986	cellular_component	cell surface
B	0015936	biological_process	coenzyme A metabolic process
B	0016740	molecular_function	transferase activity
B	0042603	cellular_component	capsule
B	0042803	molecular_function	protein homodimerization activity
B	0043236	molecular_function	laminin binding
B	0044406	biological_process	adhesion of symbiont to host
B	0046810	molecular_function	host cell extracellular matrix binding
B	0046872	molecular_function	metal ion binding
B	0120225	molecular_function	coenzyme A binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	binding site for residue MG A 801

Chain	Residue
A	GLU434
A	ASP462
A	LMR802
A	HOH917

---

site_id	AC2
Number of Residues	12
Details	binding site for residue LMR A 802

Chain	Residue
A	LEU461
A	ASP462
A	TRP541
A	ASP633
A	ALA635
A	MG801
A	HOH912
A	ASP274
A	ARG339
A	GLU434
A	GLY459
A	PHE460

---

site_id	AC3
Number of Residues	5
Details	binding site for residue MG B 801

Chain	Residue
B	GLU434
B	ASP462
B	GLV803
B	HOH903
B	HOH917

---

site_id	AC4
Number of Residues	4
Details	binding site for residue MG B 802

Chain	Residue
A	GLN557
A	HOH926
B	ARG69
B	HOH920

---

site_id	AC5
Number of Residues	10
Details	binding site for residue GLV B 803

Chain	Residue
B	ASP274
B	ARG339
B	GLU434
B	GLY459
B	PHE460
B	LEU461
B	ASP462
B	TRP541
B	MG801
B	HOH903

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	Active site: {"description":"Proton acceptor"}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	2
Details	Active site: {"description":"Proton donor"}

Chain

Residue

Details

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site_id	SWS_FT_FI3
Number of Residues	36
Details	Binding site: {}

Chain

Residue

Details

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site_id	SWS_FT_FI4
Number of Residues	2
Details	Modified residue: {"description":"Cysteine sulfenic acid (-SOH)","evidences":[{"source":"HAMAP-Rule","id":"MF_00641","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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