6C67

Mycobacterium tuberculosis adenosine kinase bound to iodotubercidin

Summary for 6C67

Entry DOI	10.2210/pdb6c67/pdb
Related	2PKF 2PKK 2PKM 2PKN
Descriptor	Adenosine kinase, (2R,3R,4S,5R)-2-(4-AMINO-5-IODO-7H-PYRROLO[2,3-D]PYRIMIDIN-7-YL)-5-(HYDROXYMETHYL)TETRAHYDROFURAN-3,4-DIOL, SODIUM ION, ... (6 entities in total)
Functional Keywords	nucleoside analog, complex, inhibitor, structural genomics, psi-2, protein structure initiative, tb structural genomics consortium, tbsgc, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological source	Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Total number of polymer chains	2
Total formula weight	70906.71
Authors	Crespo, R.A.,TB Structural Genomics Consortium (TBSGC) (deposition date: 2018-01-17, release date: 2019-05-01, Last modification date: 2023-10-04)
Primary citation	Crespo, R.A.,Dang, Q.,Zhou, N.E.,Guthrie, L.M.,Snavely, T.C.,Dong, W.,Loesch, K.A.,Suzuki, T.,You, L.,Wang, W.,O'Malley, T.,Parish, T.,Olsen, D.B.,Sacchettini, J.C. Structure-Guided Drug Design of 6-Substituted Adenosine Analogues as Potent Inhibitors of Mycobacterium tuberculosis Adenosine Kinase. J.Med.Chem., 62:4483-4499, 2019 Cited by PubMed: 31002508 DOI: 10.1021/acs.jmedchem.9b00020 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.11 Å)

Structure validation