6C67
Mycobacterium tuberculosis adenosine kinase bound to iodotubercidin
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000166 | molecular_function | nucleotide binding |
| A | 0000287 | molecular_function | magnesium ion binding |
| A | 0004001 | molecular_function | adenosine kinase activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005524 | molecular_function | ATP binding |
| A | 0005525 | molecular_function | GTP binding |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0006166 | biological_process | purine ribonucleoside salvage |
| A | 0016301 | molecular_function | kinase activity |
| A | 0016740 | molecular_function | transferase activity |
| A | 0016772 | molecular_function | transferase activity, transferring phosphorus-containing groups |
| A | 0032567 | molecular_function | dGTP binding |
| A | 0044209 | biological_process | AMP salvage |
| B | 0000166 | molecular_function | nucleotide binding |
| B | 0000287 | molecular_function | magnesium ion binding |
| B | 0004001 | molecular_function | adenosine kinase activity |
| B | 0005515 | molecular_function | protein binding |
| B | 0005524 | molecular_function | ATP binding |
| B | 0005525 | molecular_function | GTP binding |
| B | 0005886 | cellular_component | plasma membrane |
| B | 0006166 | biological_process | purine ribonucleoside salvage |
| B | 0016301 | molecular_function | kinase activity |
| B | 0016740 | molecular_function | transferase activity |
| B | 0016772 | molecular_function | transferase activity, transferring phosphorus-containing groups |
| B | 0032567 | molecular_function | dGTP binding |
| B | 0044209 | biological_process | AMP salvage |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 16 |
| Details | binding site for residue 5ID A 401 |
| Chain | Residue |
| A | SER8 |
| A | GLN172 |
| A | GLN173 |
| A | GLY254 |
| A | ASP257 |
| A | HOH553 |
| B | SER36 |
| B | HOH501 |
| A | ALA10 |
| A | ASP12 |
| A | GLY47 |
| A | GLY48 |
| A | VAL49 |
| A | ASN52 |
| A | PHE102 |
| A | PHE116 |
| site_id | AC2 |
| Number of Residues | 10 |
| Details | binding site for residue 5ID A 402 |
| Chain | Residue |
| A | GLY225 |
| A | PRO226 |
| A | VAL243 |
| A | VAL244 |
| A | GLU246 |
| A | GLN249 |
| A | VAL255 |
| A | VAL285 |
| A | LEU288 |
| A | HOH588 |
| site_id | AC3 |
| Number of Residues | 5 |
| Details | binding site for residue NA A 403 |
| Chain | Residue |
| A | ASP251 |
| A | THR253 |
| A | VAL287 |
| A | SER290 |
| A | THR291 |
| site_id | AC4 |
| Number of Residues | 6 |
| Details | binding site for residue GOL A 404 |
| Chain | Residue |
| A | THR105 |
| A | ILE113 |
| A | SER115 |
| B | CYS104 |
| B | THR105 |
| B | ILE113 |
| site_id | AC5 |
| Number of Residues | 3 |
| Details | binding site for residue SO4 A 405 |
| Chain | Residue |
| A | ASN195 |
| A | GLY256 |
| A | HOH508 |
| site_id | AC6 |
| Number of Residues | 16 |
| Details | binding site for residue 5ID B 401 |
| Chain | Residue |
| A | SER36 |
| A | HOH502 |
| B | SER8 |
| B | ALA10 |
| B | ASP12 |
| B | GLY47 |
| B | GLY48 |
| B | VAL49 |
| B | ASN52 |
| B | PHE102 |
| B | PHE116 |
| B | GLN172 |
| B | GLN173 |
| B | GLY254 |
| B | ASP257 |
| B | HOH551 |
| site_id | AC7 |
| Number of Residues | 10 |
| Details | binding site for residue 5ID B 402 |
| Chain | Residue |
| B | MET110 |
| B | GLY225 |
| B | PRO226 |
| B | VAL243 |
| B | VAL244 |
| B | GLU246 |
| B | PRO252 |
| B | VAL255 |
| B | VAL285 |
| B | LEU288 |
| site_id | AC8 |
| Number of Residues | 5 |
| Details | binding site for residue NA B 403 |
| Chain | Residue |
| B | ASP251 |
| B | THR253 |
| B | VAL287 |
| B | SER290 |
| B | THR291 |
| site_id | AC9 |
| Number of Residues | 4 |
| Details | binding site for residue SO4 B 404 |
| Chain | Residue |
| B | ASN195 |
| B | GLY256 |
| B | HOH510 |
| B | HOH515 |
Functional Information from PROSITE/UniProt
| site_id | PS00583 |
| Number of Residues | 25 |
| Details | PFKB_KINASES_1 pfkB family of carbohydrate kinases signature 1. GGvAgNMAfaIgVLGgevalvgaaG |
| Chain | Residue | Details |
| A | GLY47-GLY71 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | Active site: {"description":"Proton acceptor","evidences":[{"source":"PubMed","id":"17597075","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 16 |
| Details | Binding site: {"description":"in other chain","evidences":[{"source":"PubMed","id":"17597075","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"2PKM","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"17597075","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"2PKM","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"17597075","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"25259627","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"4O1G","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 10 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"17597075","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"25259627","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"2PKN","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4O1G","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 2 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"25259627","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"4O1G","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"N-acetylthreonine","evidences":[{"source":"PubMed","id":"21969609","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
