5JA3
Mycobacterium tuberculosis Dihydrofolate Reductase complexed with beta- NADPH and 3'-(3-(2,4-diamino-6-ethylpyrimidin-5-yl)prop-2-yn-1-yl)-4'-methoxy-[1,1'-b iphenyl]-4-carboxylic acid (UCP1106)
Summary for 5JA3
Entry DOI | 10.2210/pdb5ja3/pdb |
Descriptor | Dihydrofolate reductase, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, 4-[3-[3-[2,4-bis(azanyl)-6-ethyl-pyrimidin-5-yl]prop-2-ynyl]-4-methoxy-phenyl]benzoic acid, ... (4 entities in total) |
Functional Keywords | dhfr, antifolate, folate pathway, oxidoreductase |
Biological source | Mycobacterium tuberculosis |
Total number of polymer chains | 4 |
Total formula weight | 75235.44 |
Authors | Hajian, B.,Anderson, A.C. (deposition date: 2016-04-11, release date: 2016-08-24, Last modification date: 2024-03-06) |
Primary citation | Hajian, B.,Scocchera, E.,Keshipeddy, S.,G-Dayanandan, N.,Shoen, C.,Krucinska, J.,Reeve, S.,Cynamon, M.,Anderson, A.C.,Wright, D.L. Propargyl-Linked Antifolates Are Potent Inhibitors of Drug-Sensitive and Drug-Resistant Mycobacterium tuberculosis. Plos One, 11:e0161740-e0161740, 2016 Cited by PubMed: 27580226DOI: 10.1371/journal.pone.0161740 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.814 Å) |
Structure validation
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