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5JA3

Mycobacterium tuberculosis Dihydrofolate Reductase complexed with beta- NADPH and 3'-(3-(2,4-diamino-6-ethylpyrimidin-5-yl)prop-2-yn-1-yl)-4'-methoxy-[1,1'-b iphenyl]-4-carboxylic acid (UCP1106)

Summary for 5JA3
Entry DOI10.2210/pdb5ja3/pdb
DescriptorDihydrofolate reductase, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, 4-[3-[3-[2,4-bis(azanyl)-6-ethyl-pyrimidin-5-yl]prop-2-ynyl]-4-methoxy-phenyl]benzoic acid, ... (4 entities in total)
Functional Keywordsdhfr, antifolate, folate pathway, oxidoreductase
Biological sourceMycobacterium tuberculosis
Total number of polymer chains4
Total formula weight75235.44
Authors
Hajian, B.,Anderson, A.C. (deposition date: 2016-04-11, release date: 2016-08-24, Last modification date: 2024-03-06)
Primary citationHajian, B.,Scocchera, E.,Keshipeddy, S.,G-Dayanandan, N.,Shoen, C.,Krucinska, J.,Reeve, S.,Cynamon, M.,Anderson, A.C.,Wright, D.L.
Propargyl-Linked Antifolates Are Potent Inhibitors of Drug-Sensitive and Drug-Resistant Mycobacterium tuberculosis.
Plos One, 11:e0161740-e0161740, 2016
Cited by
PubMed: 27580226
DOI: 10.1371/journal.pone.0161740
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.814 Å)
Structure validation

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