5JA3

Mycobacterium tuberculosis Dihydrofolate Reductase complexed with beta- NADPH and 3'-(3-(2,4-diamino-6-ethylpyrimidin-5-yl)prop-2-yn-1-yl)-4'-methoxy-[1,1'-b iphenyl]-4-carboxylic acid (UCP1106)

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D (A, B, C, D)	Dihydrofolate reductase	polymer	159	17661.0	4	UniProt (P9WNX0) Pfam (PF00186) UniProt (by SIFTS) (P9WNX1)	Mycobacterium tuberculosis
2	E, G, I, K (A, B, C, D)	NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE	non-polymer		745.4	4	Chemie (NDP)
3	F, H, J, L (A, B, C, D)	4-[3-[3-[2,4-bis(azanyl)-6-ethyl-pyrimidin-5-yl]prop-2-ynyl]-4-methoxy-phenyl]benzoic acid	non-polymer		402.4	4	Chemie (U06)
4	M, N, O, P (A, B, C, D)	water	water		18.0	39	Chemie (HOH)

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	70644.0
Non-Polymers*	Number of molecules	8
	Total formula weight	4591.5
All*	Total formula weight	75235.4

*Water molecules are not included.