5JA3
Mycobacterium tuberculosis Dihydrofolate Reductase complexed with beta- NADPH and 3'-(3-(2,4-diamino-6-ethylpyrimidin-5-yl)prop-2-yn-1-yl)-4'-methoxy-[1,1'-b iphenyl]-4-carboxylic acid (UCP1106)
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0004146 | molecular_function | dihydrofolate reductase activity |
A | 0005829 | cellular_component | cytosol |
A | 0006545 | biological_process | glycine biosynthetic process |
A | 0006730 | biological_process | one-carbon metabolic process |
A | 0016491 | molecular_function | oxidoreductase activity |
A | 0046452 | biological_process | dihydrofolate metabolic process |
A | 0046654 | biological_process | tetrahydrofolate biosynthetic process |
A | 0046655 | biological_process | folic acid metabolic process |
A | 0050661 | molecular_function | NADP binding |
A | 0070401 | molecular_function | NADP+ binding |
B | 0004146 | molecular_function | dihydrofolate reductase activity |
B | 0005829 | cellular_component | cytosol |
B | 0006545 | biological_process | glycine biosynthetic process |
B | 0006730 | biological_process | one-carbon metabolic process |
B | 0016491 | molecular_function | oxidoreductase activity |
B | 0046452 | biological_process | dihydrofolate metabolic process |
B | 0046654 | biological_process | tetrahydrofolate biosynthetic process |
B | 0046655 | biological_process | folic acid metabolic process |
B | 0050661 | molecular_function | NADP binding |
B | 0070401 | molecular_function | NADP+ binding |
C | 0004146 | molecular_function | dihydrofolate reductase activity |
C | 0005829 | cellular_component | cytosol |
C | 0006545 | biological_process | glycine biosynthetic process |
C | 0006730 | biological_process | one-carbon metabolic process |
C | 0016491 | molecular_function | oxidoreductase activity |
C | 0046452 | biological_process | dihydrofolate metabolic process |
C | 0046654 | biological_process | tetrahydrofolate biosynthetic process |
C | 0046655 | biological_process | folic acid metabolic process |
C | 0050661 | molecular_function | NADP binding |
C | 0070401 | molecular_function | NADP+ binding |
D | 0004146 | molecular_function | dihydrofolate reductase activity |
D | 0005829 | cellular_component | cytosol |
D | 0006545 | biological_process | glycine biosynthetic process |
D | 0006730 | biological_process | one-carbon metabolic process |
D | 0016491 | molecular_function | oxidoreductase activity |
D | 0046452 | biological_process | dihydrofolate metabolic process |
D | 0046654 | biological_process | tetrahydrofolate biosynthetic process |
D | 0046655 | biological_process | folic acid metabolic process |
D | 0050661 | molecular_function | NADP binding |
D | 0070401 | molecular_function | NADP+ binding |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 26 |
Details | binding site for residue NDP A 201 |
Chain | Residue |
A | TRP6 |
A | ARG45 |
A | THR46 |
A | LEU65 |
A | SER66 |
A | ARG67 |
A | GLN68 |
A | GLY80 |
A | ILE94 |
A | GLY95 |
A | GLY96 |
A | ALA7 |
A | GLY97 |
A | GLN98 |
A | VAL99 |
A | TYR100 |
A | LEU102 |
A | ALA126 |
A | U06202 |
A | ILE14 |
A | GLY15 |
A | GLY18 |
A | ASP19 |
A | ILE20 |
A | GLY43 |
A | ARG44 |
site_id | AC2 |
Number of Residues | 18 |
Details | binding site for residue U06 A 202 |
Chain | Residue |
A | ILE5 |
A | TRP6 |
A | ALA7 |
A | ASP19 |
A | ILE20 |
A | ASP27 |
A | GLN28 |
A | PHE31 |
A | ARG32 |
A | SER49 |
A | LEU50 |
A | PRO51 |
A | LEU57 |
A | ARG60 |
A | ILE94 |
A | TYR100 |
A | NDP201 |
A | HOH307 |
site_id | AC3 |
Number of Residues | 25 |
Details | binding site for residue NDP B 201 |
Chain | Residue |
B | TRP6 |
B | ALA7 |
B | ILE14 |
B | GLY15 |
B | GLY18 |
B | ASP19 |
B | ILE20 |
B | GLY43 |
B | ARG44 |
B | ARG45 |
B | THR46 |
B | LEU65 |
B | SER66 |
B | ARG67 |
B | GLN68 |
B | GLY95 |
B | GLY96 |
B | GLY97 |
B | GLN98 |
B | VAL99 |
B | TYR100 |
B | LEU102 |
B | ALA126 |
B | U06202 |
B | HOH308 |
site_id | AC4 |
Number of Residues | 14 |
Details | binding site for residue U06 B 202 |
Chain | Residue |
B | ILE5 |
B | TRP6 |
B | ILE20 |
B | ASP27 |
B | GLN28 |
B | PHE31 |
B | ARG32 |
B | SER49 |
B | PRO51 |
B | ILE94 |
B | GLY95 |
B | TYR100 |
B | NDP201 |
B | HOH304 |
site_id | AC5 |
Number of Residues | 25 |
Details | binding site for residue NDP C 201 |
Chain | Residue |
C | ILE94 |
C | GLY96 |
C | GLY97 |
C | GLN98 |
C | VAL99 |
C | TYR100 |
C | LEU102 |
C | U06202 |
D | SER147 |
C | TRP6 |
C | ALA7 |
C | ILE14 |
C | GLY15 |
C | GLY18 |
C | ASP19 |
C | ILE20 |
C | GLY43 |
C | ARG44 |
C | ARG45 |
C | THR46 |
C | SER49 |
C | LEU65 |
C | SER66 |
C | ARG67 |
C | GLY80 |
site_id | AC6 |
Number of Residues | 15 |
Details | binding site for residue U06 C 202 |
Chain | Residue |
C | ILE5 |
C | TRP6 |
C | ALA7 |
C | ASP19 |
C | ILE20 |
C | ASP27 |
C | GLN28 |
C | PHE31 |
C | ARG32 |
C | SER49 |
C | LEU57 |
C | ARG60 |
C | ILE94 |
C | TYR100 |
C | NDP201 |
site_id | AC7 |
Number of Residues | 23 |
Details | binding site for residue NDP D 201 |
Chain | Residue |
D | TRP6 |
D | ALA7 |
D | ILE14 |
D | GLY18 |
D | ASP19 |
D | ILE20 |
D | GLY43 |
D | ARG44 |
D | ARG45 |
D | THR46 |
D | LEU65 |
D | SER66 |
D | ARG67 |
D | ILE94 |
D | GLY95 |
D | GLY96 |
D | GLY97 |
D | GLN98 |
D | VAL99 |
D | TYR100 |
D | LEU102 |
D | ALA126 |
D | U06202 |
site_id | AC8 |
Number of Residues | 18 |
Details | binding site for residue U06 D 202 |
Chain | Residue |
D | ILE5 |
D | TRP6 |
D | ALA7 |
D | ASP19 |
D | ILE20 |
D | ASP27 |
D | GLN28 |
D | PHE31 |
D | ARG32 |
D | SER49 |
D | LEU50 |
D | PRO51 |
D | LEU57 |
D | ARG60 |
D | ILE94 |
D | TYR100 |
D | NDP201 |
D | HOH307 |
Functional Information from PROSITE/UniProt
site_id | PS00075 |
Number of Residues | 23 |
Details | DHFR_1 Dihydrofolate reductase (DHFR) domain signature. VIGrggdIPWrlpe.DqahFreiT |
Chain | Residue | Details |
A | VAL13-THR35 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 48 |
Details | BINDING: |
Chain | Residue | Details |
A | ILE5 | |
A | ILE94 | |
A | TYR100 | |
A | THR113 | |
B | ILE5 | |
B | TRP6 | |
B | ILE14 | |
B | ASP27 | |
B | ARG32 | |
B | GLY43 | |
B | ARG60 | |
A | TRP6 | |
B | LEU65 | |
B | GLY80 | |
B | ILE94 | |
B | TYR100 | |
B | THR113 | |
C | ILE5 | |
C | TRP6 | |
C | ILE14 | |
C | ASP27 | |
C | ARG32 | |
A | ILE14 | |
C | GLY43 | |
C | ARG60 | |
C | LEU65 | |
C | GLY80 | |
C | ILE94 | |
C | TYR100 | |
C | THR113 | |
D | ILE5 | |
D | TRP6 | |
D | ILE14 | |
A | ASP27 | |
D | ASP27 | |
D | ARG32 | |
D | GLY43 | |
D | ARG60 | |
D | LEU65 | |
D | GLY80 | |
D | ILE94 | |
D | TYR100 | |
D | THR113 | |
A | ARG32 | |
A | GLY43 | |
A | ARG60 | |
A | LEU65 | |
A | GLY80 |