PDB: 250 件ウェブページステータス検索Chemie searchBIRD

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5A3T	Crystal structure of human PLU-1 (JARID1B) in complex with KDM5-C49 (2-(((2-((2-(dimethylamino)ethyl)(ethyl)amino)-2-oxoethyl)amino)methyl) isonicotinic acid). 分子名称: 1,2-ETHANEDIOL, 2-{[(2-{[(E)-2-(dimethylamino)ethenyl](ethyl)amino}-2-oxoethyl)amino]methyl}pyridine-4-carboxylic acid, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, ... 著者 Srikannathasan, V, Johansson, C, Gileadi, C, Kopec, J, Strain-Damerell, C, Kupinska, K, BurgessBrown, N.A, von Delft, F, Arrowsmith, C.H, Bountra, C, Edwards, A.M, Oppermann, U. 登録日 2015-06-02 公開日 2015-06-17 最終更新日 2016-06-29 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Structural Analysis of Human Kdm5B Guides Histone Demethylase Inhibitor Development. Nat.Chem.Biol., 12, 2016
5FUN	Crystal structure of human JARID1B in complex with GSK467 分子名称: 1,2-ETHANEDIOL, 2-[(1-benzyl-1H-pyrazol-4-yl)oxy]pyrido[3,4-d]pyrimidin-4(3H)-one, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, ... 著者 Srikannathasan, V, Johansson, C, Gileadi, C, Kopec, J, von Delft, F, Arrowsmith, C.H, Bountra, C, Edwards, A, Brennan, P, Oppermann, U. 登録日 2016-01-28 公開日 2016-04-13 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Structural Analysis of Human Kdm5B Guides Histone Demethylase Inhibitor Development. Nat.Chem.Biol., 12, 2016
5FWJ	Crystal structure of human JARID1C in complex with KDM5-C49 分子名称: 2-{[(2-{[(E)-2-(dimethylamino)ethenyl](ethyl)amino}-2-oxoethyl)amino]methyl}pyridine-4-carboxylic acid, HISTONE DEMETHYLASE JARID1C, MAGNESIUM ION, ... 著者 Srikannathasan, V, Szykowska, A, Strain-Damerell, C, Kopec, J, Nowak, R, Gileadi, C, Johansson, C, Kupinska, K, Burgess-Brown, N.A, Shrestha, L, Dong, W, von Delft, F, Arrowsmith, C.H, Bountra, C, Edwards, A, Huber, K, Oppermann, U. 登録日 2016-02-17 公開日 2016-04-13 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Structural Analysis of Human Kdm5B Guides Histone Demethylase Inhibitor Development. Nat.Chem.Biol., 12, 2016
5FPV	Crystal structure of human JMJD2A in complex with compound KDOAM20A 分子名称: 2-{[(2-{[(E)-2-(dimethylamino)ethenyl](ethyl)amino}-2-oxoethyl)amino]methyl}pyridine-4-carboxylic acid, LYSINE-SPECIFIC DEMETHYLASE 4A, MANGANESE (II) ION, ... 著者 Srikannathasan, V, Gileadi, C, von Delft, F, Arrowsmith, C.H, Bountra, C, Edwards, A, Oppermann, U. 登録日 2015-12-03 公開日 2016-01-13 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (2.44 Å) 主引用文献 Structural Analysis of Human Kdm5B Guides Histone Demethylase Inhibitor Development. Nat.Chem.Biol., 12, 2016
5FUP	Crystal structure of human JARID1B in complex with 2-oxoglutarate. 分子名称: 1,2-ETHANEDIOL, 2-OXOGLUTARIC ACID, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, ... 著者 Nowak, R, Srikannathasan, V, Johansson, C, Gileadi, C, Kupinska, K, Strain-Damerell, C, Szykowska, A, Talon, R, von Delft, F, Burgess-Brown, N.A, Arrowsmith, C.H, Bountra, C, Edwards, A.M, Oppermann, U. 登録日 2016-01-28 公開日 2016-03-23 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (2.15 Å) 主引用文献 Structural Analysis of Human Kdm5B Guides Histone Demethylase Inhibitor Development. Nat.Chem.Biol., 12, 2016
5FPL	Crystal structure of human JARID1B in complex with CCT363901 分子名称: 1,2-ETHANEDIOL, 8-[4-(2-azanylethyl)pyrazol-1-yl]-3H-pyrido[3,4-d]pyrimidin-4-one, DIMETHYL SULFOXIDE, ... 著者 Srikannathasan, V, Yann-Vai, L.B, Nowak, R, Johansson, C, Gileadi, C, von Delft, F, Arrowsmith, C.H, Bountra, C, Edwards, A, Brennan, P, Huber, K, Oppermann, U. 登録日 2015-12-02 公開日 2016-01-20 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (2.35 Å) 主引用文献 8-Substituted Pyrido[3,4-D]Pyrimidin-4(3H)-One Derivatives as Potent, Cell Permeable, Kdm4 (Jmjd2) and Kdm5 (Jarid1) Histone Lysine Demethylase Inhibitors. J.Med.Chem., 59, 2016
5FPU	Crystal structure of human JARID1B in complex with GSKJ1 分子名称: 1,2-ETHANEDIOL, 3-[[2-pyridin-2-yl-6-(1,2,4,5-tetrahydro-3-benzazepin-3-yl)pyrimidin-4-yl]amino]propanoic acid, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, ... 著者 Srikannathasan, V, Nowak, R, Johansson, C, Gileadi, C, von Delft, F, Arrowsmith, C.H, Bountra, C, Edwards, A, Oppermann, U. 登録日 2015-12-03 公開日 2016-01-13 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (2.24 Å) 主引用文献 Structural Analysis of Human Kdm5B Guides Histone Demethylase Inhibitor Development. Nat.Chem.Biol., 12, 2016
5FV3	Crystal structure of human JARID1B construct c2 in complex with N- Oxalylglycine. 分子名称: 1,2-ETHANEDIOL, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, CHLORIDE ION, ... 著者 Nowak, R, Srikannathasan, V, Johansson, C, Gileadi, C, Kupinska, K, Strain-Damerell, C, Szykowska, A, Talon, R, von Delft, F, Burgess-Brown, N.A, Arrowsmith, C.H, Bountra, C, Edwards, A.M, Oppermann, U. 登録日 2016-02-02 公開日 2016-02-17 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (2.37 Å) 主引用文献 Structural Analysis of Human Kdm5B Guides Histone Demethylase Inhibitor Development. Nat.Chem.Biol., 12, 2016
5V9T	Crystal structure of selective pyrrolidine amide KDM5a inhibitor N-{(3R)-1-[3-(propan-2-yl)-1H-pyrazole-5-carbonyl]pyrrolidin-3-yl}cyclopropanecarboxamide (compound 48) 分子名称: Lysine-specific demethylase 5A, N-{(3R)-1-[3-(propan-2-yl)-1H-pyrazole-5-carbonyl]pyrrolidin-3-yl}cyclopropanecarboxamide, NICKEL (II) ION, ... 著者 Kiefer, J.R, Liang, J, Vinogradova, M. 登録日 2017-03-23 公開日 2017-05-10 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (3.05 Å) 主引用文献 From a novel HTS hit to potent, selective, and orally bioavailable KDM5 inhibitors. Bioorg. Med. Chem. Lett., 27, 2017
7D4A	The Crystal Structure of human JMJD2A Tudor domain from Biortus 分子名称: Lysine-specific demethylase 4A, SULFATE ION 著者 Wang, F, Lv, Z, Cheng, W, Lin, D, Ju, C, Bao, X, Zhu, B. 登録日 2020-09-23 公開日 2020-10-07 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (2.201 Å) 主引用文献 The Crystal Structure of human JMJD2A from Biortus. To Be Published
7E9M	Crystal Structure of Spindlin1 bound to SPINDOC Docpep3 分子名称: Peptide from Spindlin interactor and repressor of chromatin-binding protein, Spindlin-1 著者 Zhao, F, Li, H. 登録日 2021-03-04 公開日 2022-06-15 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Molecular basis for SPINDOC-Spindlin1 engagement and its role in transcriptional inhibition to be published
7EA1	Crystal Structure of Spindlin1 bound to SPINDOC Docpep2 分子名称: Peptide from Spindlin interactor and repressor of chromatin-binding protein, Spindlin-1 著者 Zhao, F, Li, H. 登録日 2021-03-05 公開日 2022-06-15 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (2.7 Å) 主引用文献 Molecular basis for SPINDOC-Spindlin1 engagement and its role in transcriptional inhibition to be published
5VAR	Crystal structure of KDM4A tandem TUDOR domain in complex with a tri-methyl lysine competitive inhibitor 分子名称: (1R,2S,3R,4S)-3-[(dimethylamino)methyl]-1-phenylbicyclo[2.2.1]heptan-2-ol, Lysine-specific demethylase 4A 著者 Judge, R.A, Upadhyay, A.K. 登録日 2017-03-27 公開日 2018-03-28 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (1.83 Å) 主引用文献 Targeting lysine specific demethylase 4A (KDM4A) tandem TUDOR domain - A fragment based approach. Bioorg. Med. Chem. Lett., 28, 2018
5WAK	Crystal Structure of a Suz12-Rbbp4 Binary Complex 分子名称: Histone-binding protein RBBP4, Polycomb protein SUZ12, ZINC ION 著者 Chen, S, Jiao, L, Liu, X. 登録日 2017-06-26 公開日 2018-03-14 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (3.2 Å) 主引用文献 Unique Structural Platforms of Suz12 Dictate Distinct Classes of PRC2 for Chromatin Binding. Mol. Cell, 69, 2018
7BCY	X-ray structure of WDR5delta24 bound to the Kaposi's sarcoma herpesvirus LANA win motif peptide 分子名称: ORF 73, WD repeat-containing protein 5 著者 McVey, C.E, Kaye, K.M. 登録日 2020-12-21 公開日 2021-12-08 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (1.5 Å) 主引用文献 MLL1 is regulated by KSHV LANA and is important for virus latency. Nucleic Acids Res., 49, 2021
7BED	X-ray structure of WDR5 bound to the WDR5 win motif peptide 分子名称: SULFATE ION, WD repeat-containing protein 5 著者 McVey, C.E, Kaye, K.M. 登録日 2020-12-23 公開日 2021-12-08 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (1.26 Å) 主引用文献 MLL1 is regulated by KSHV LANA and is important for virus latency. Nucleic Acids Res., 49, 2021
5V9P	Crystal structure of pyrrolidine amide inhibitor [(3S)-3-(4-bromo-1H-pyrazol-1-yl)pyrrolidin-1-yl][3-(propan-2-yl)-1H-pyrazol-5-yl]methanone (compound 35) in complex with KDM5A 分子名称: Lysine-specific demethylase 5A, NICKEL (II) ION, SULFATE ION, ... 著者 Kiefer, J.R, Liang, J, Vinogradova, M. 登録日 2017-03-23 公開日 2017-05-10 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (3 Å) 主引用文献 From a novel HTS hit to potent, selective, and orally bioavailable KDM5 inhibitors. Bioorg. Med. Chem. Lett., 27, 2017
7CNA	Crystal structure of Spindlin1/C11orf84 complex bound to histone H3K4me3K9me3 peptide 分子名称: ALA-ARG-THR-M3L-GLN-THR-ALA-ARG-M3L-SER-GLY, ALA-ARG-THR-M3L-GLN-THR-ALA-ARG-M3L-SER-THR, BENZAMIDINE, ... 著者 Qian, C.M. 登録日 2020-07-30 公開日 2021-01-13 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (1.6 Å) 主引用文献 Structural mechanism of bivalent histone H3K4me3K9me3 recognition by the Spindlin1/C11orf84 complex in rRNA transcription activation. Nat Commun, 12, 2021
5WAI	Crystal Structure of a Suz12-Rbbp4-Jarid2-Aebp2 Heterotetrameric Complex 分子名称: Histone-binding protein RBBP4, Jumonji, AT-rich interactive domain 2, ... 著者 Chen, S, Jiao, L, Liu, X. 登録日 2017-06-26 公開日 2018-03-14 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (2.9 Å) 主引用文献 Unique Structural Platforms of Suz12 Dictate Distinct Classes of PRC2 for Chromatin Binding. Mol. Cell, 69, 2018
5WMF	Crystal structure of the Hexameric Ring of Epstein-Barr Virus Nuclear Antigen-1, EBNA1 分子名称: Epstein-Barr nuclear antigen 1 著者 Messick, T.E. 登録日 2017-07-28 公開日 2017-08-09 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Structural and Functional Basis for an EBNA1 Hexameric Ring in Epstein-Barr Virus Episome Maintenance. J. Virol., 91, 2017
3QLC	Complex structure of ATRX ADD domain bound to unmodified H3 1-15 peptide 分子名称: Transcriptional regulator ATRX, ZINC ION, peptide of Histone H3.3 著者 Li, H, Patel, D.J. 登録日 2011-02-02 公開日 2011-06-15 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 ATRX ADD domain links an atypical histone methylation recognition mechanism to human mental-retardation syndrome Nat.Struct.Mol.Biol., 18, 2011
3QLN	Crystal structure of ATRX ADD domain in free state 分子名称: Transcriptional regulator ATRX, ZINC ION 著者 Li, H, Patel, D.J. 登録日 2011-02-03 公開日 2011-06-15 最終更新日 2024-03-20 実験手法 X-RAY DIFFRACTION (1.901 Å) 主引用文献 ATRX ADD domain links an atypical histone methylation recognition mechanism to human mental-retardation syndrome Nat.Struct.Mol.Biol., 18, 2011
3QZS	Crystal Structure of BPTF bromo in complex with histone H4K16ac - Form I 分子名称: Histone H4, Nucleosome-remodeling factor subunit BPTF 著者 Li, H, Ruthenburg, A.J, Patel, D.J. 登録日 2011-03-07 公開日 2011-06-01 最終更新日 2023-12-06 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Recognition of a Mononucleosomal Histone Modification Pattern by BPTF via Multivalent Interactions. Cell(Cambridge,Mass.), 145, 2011
3QZV	Crystal Structure of BPTF PHD-linker-bromo in complex with histone H4K12ac peptide 分子名称: Histone H4, Nucleosome-remodeling factor subunit BPTF, ZINC ION 著者 Li, H, Ruthenburg, A.J, Patel, D.J. 登録日 2011-03-07 公開日 2011-06-01 最終更新日 2023-12-06 実験手法 X-RAY DIFFRACTION (1.999 Å) 主引用文献 Recognition of a Mononucleosomal Histone Modification Pattern by BPTF via Multivalent Interactions. Cell(Cambridge,Mass.), 145, 2011
5KR7	KDM4C bound to pyrazolo-pyrimidine scaffold 分子名称: 6-ethyl-2,5-dimethyl-7-oxidanylidene-4~{H}-pyrazolo[1,5-a]pyrimidine-3-carbonitrile, CHLORIDE ION, FE (II) ION, ... 著者 Bellon, S.F, Poy, F, Setser, J.W. 登録日 2016-07-07 公開日 2016-08-17 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Identification of potent, selective KDM5 inhibitors. Bioorg.Med.Chem.Lett., 26, 2016

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