PDB: 262 件ウェブページステータス検索Chemie searchBIRD

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7ZEX	Complex Cyp33-RRMdelta alpha : UAAUGUCG RNA 分子名称: Isoform 3 of Peptidyl-prolyl cis-trans isomerase E, RNA (5'-R(*UP*AP*AP*UP*GP*UP*CP*G)-3') 著者 Blatter, M, Allain, F, Meylan, C. 登録日 2022-03-31 公開日 2022-05-04 最終更新日 2024-06-19 実験手法 SOLUTION NMR 主引用文献 RNA binding induces an allosteric switch in Cyp33 to repress MLL1-mediated transcription. Sci Adv, 9, 2023
6L87	Solution structure of the tandem PWWP-ARID domains of human RBBP1 分子名称: AT-rich interactive domain-containing protein 4A 著者 Gong, W.B, Perrett, S, Feng, Y.G. 登録日 2019-11-05 公開日 2021-01-06 最終更新日 2024-05-15 実験手法 SOLUTION NMR 主引用文献 Structural insight into chromatin recognition by multiple domains of the tumor suppressor RBBP1. J.Mol.Biol., 2021
7ZEY	Complex Cyp33-RRM : MLL1-PHD3 分子名称: MLL cleavage product N320, Peptidyl-prolyl cis-trans isomerase E, ZINC ION 著者 Blatter, M, Allain, F, Meylan, C. 登録日 2022-03-31 公開日 2022-04-13 最終更新日 2024-06-19 実験手法 SOLUTION NMR 主引用文献 RNA binding induces an allosteric switch in Cyp33 to repress MLL1-mediated transcription. Sci Adv, 9, 2023
6TUY	Human LSD1/CoREST bound to the quinazoline inhibitor MC4106 分子名称: CHLORIDE ION, DIMETHYL SULFOXIDE, FLAVIN-ADENINE DINUCLEOTIDE, ... 著者 Mattevi, A, Marrocco, B. 登録日 2020-01-08 公開日 2021-07-21 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 Novel non-covalent LSD1 inhibitors endowed with anticancer effects in leukemia and solid tumor cellular models. Eur.J.Med.Chem., 237, 2022
6VHF	Crystal structure of RbBP5 interacting domain of Cfp1 分子名称: PHD-type domain-containing protein, ZINC ION 著者 Joshi, M, Couture, J.F. 登録日 2020-01-09 公開日 2020-01-22 最終更新日 2024-04-03 実験手法 X-RAY DIFFRACTION (2.311 Å) 主引用文献 A non-canonical monovalent zinc finger stabilizes the integration of Cfp1 into the H3K4 methyltransferase complex COMPASS. Nucleic Acids Res., 48, 2020
6WKR	PRC2-AEBP2-JARID2 bound to H2AK119ub1 nucleosome 分子名称: DNA (314-MER), Histone H2A type 1, Histone H2B 1.1, ... 著者 Kasinath, V, Nogales, E, Beck, C, Sauer, P, Poepsel, S, Kosmatka, J, Faini, M, Toso, D, Aebersold, R. 登録日 2020-04-16 公開日 2021-02-03 実験手法 ELECTRON MICROSCOPY (3.5 Å) 主引用文献 JARID2 and AEBP2 regulate PRC2 in the presence of H2AK119ub1 and other histone modifications. Science, 371, 2021
2GF7	Double tudor domain structure 分子名称: Jumonji domain-containing protein 2A, SULFATE ION 著者 Huang, Y, Fang, J, Bedford, M.T, Zhang, Y, Xu, R.M. 登録日 2006-03-21 公開日 2006-05-02 最終更新日 2024-02-14 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Recognition of histone H3 lysine-4 methylation by the double tudor domain of JMJD2A Science, 312, 2006
2MUM	Solution structure of the PHD domain of Yeast YNG2 分子名称: Chromatin modification-related protein YNG2, ZINC ION 著者 Taeb, S, Kaustov, L, Lemak, A, Farhadi, S, Sheng, Y. 登録日 2014-09-12 公開日 2014-12-24 最終更新日 2024-05-15 実験手法 SOLUTION NMR 主引用文献 Solution structure of the PHD domain of Yeast YNG2 To be Published
2NS2	Crystal Structure of Spindlin1 分子名称: PHOSPHATE ION, Spindlin-1 著者 Zhao, Q, Qin, L, Jiang, F, Wu, B, Yue, W, Xu, F, Rong, Z, Yuan, H, Xie, X, Gao, Y, Bai, C, Bartlam, M. 登録日 2006-11-02 公開日 2006-11-28 最終更新日 2023-12-27 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Structure of human spindlin1. Tandem tudor-like domains for cell cycle regulation J.Biol.Chem., 282, 2007
2PUY	Crystal Structure of the BHC80 PHD finger 分子名称: Histone H3, PHD finger protein 21A, ZINC ION 著者 Horton, J.R, Cheng, X, Collins, R.E. 登録日 2007-05-09 公開日 2007-08-14 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (1.43 Å) 主引用文献 Recognition of unmethylated histone H3 lysine 4 links BHC80 to LSD1-mediated gene repression. Nature, 448, 2007
3QL9	Monoclinic complex structure of ATRX ADD bound to histone H3K9me3 peptide 分子名称: Transcriptional regulator ATRX, ZINC ION, peptide of Histone H3.3 著者 Xiang, B, Li, H. 登録日 2011-02-02 公開日 2011-06-15 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (0.93 Å) 主引用文献 ATRX ADD domain links an atypical histone methylation recognition mechanism to human mental-retardation syndrome Nat.Struct.Mol.Biol., 18, 2011
3QLN	Crystal structure of ATRX ADD domain in free state 分子名称: Transcriptional regulator ATRX, ZINC ION 著者 Li, H, Patel, D.J. 登録日 2011-02-03 公開日 2011-06-15 最終更新日 2024-03-20 実験手法 X-RAY DIFFRACTION (1.901 Å) 主引用文献 ATRX ADD domain links an atypical histone methylation recognition mechanism to human mental-retardation syndrome Nat.Struct.Mol.Biol., 18, 2011
3QLA	Hexagonal complex structure of ATRX ADD bound to H3K9me3 peptide 分子名称: POTASSIUM ION, Transcriptional regulator ATRX, ZINC ION, ... 著者 Xiang, B, Li, H. 登録日 2011-02-02 公開日 2011-06-15 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (1.6 Å) 主引用文献 ATRX ADD domain links an atypical histone methylation recognition mechanism to human mental-retardation syndrome Nat.Struct.Mol.Biol., 18, 2011
5A3W	Crystal structure of human PLU-1 (JARID1B) in complex with Pyridine-2, 6-dicarboxylic Acid (PDCA) 分子名称: 1,2-ETHANEDIOL, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, LYSINE-SPECIFIC DEMETHYLASE 5B, ... 著者 Srikannathasan, V, Johansson, C, Gileadi, C, Kopec, J, Strain-Damerell, C, Kupinska, K, Burgess-Brown, N.A, von Delft, F, Arrowsmith, C.H, Bountra, C, Edwards, A.M, Oppermann, U. 登録日 2015-06-03 公開日 2015-06-17 最終更新日 2024-05-08 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Structural Analysis of Human Kdm5B Guides Histone Demethylase Inhibitor Development. Nat.Chem.Biol., 12, 2016
3QZS	Crystal Structure of BPTF bromo in complex with histone H4K16ac - Form I 分子名称: Histone H4, Nucleosome-remodeling factor subunit BPTF 著者 Li, H, Ruthenburg, A.J, Patel, D.J. 登録日 2011-03-07 公開日 2011-06-01 最終更新日 2023-12-06 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Recognition of a Mononucleosomal Histone Modification Pattern by BPTF via Multivalent Interactions. Cell(Cambridge,Mass.), 145, 2011
3SMR	Crystal structure of human WD repeat domain 5 with compound 分子名称: 1,2-ETHANEDIOL, 2-chloro-N-[2-(4-methylpiperazin-1-yl)-5-nitrophenyl]benzamide, UNKNOWN ATOM OR ION, ... 著者 Dong, A, Dombrovski, L, Wasney, G.A, Tempel, W, Senisterra, G, Bolshan, Y, Smil, D, Nguyen, K.T, Hajian, T, Poda, G, Al-Awar, R, Bountra, C, Weigelt, J, Edwards, A.M, Brown, P.J, Schapira, M, Arrowsmith, C.H, Vedadi, M, Wu, H, Structural Genomics Consortium (SGC) 登録日 2011-06-28 公開日 2011-08-31 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (1.82 Å) 主引用文献 Small-molecule inhibition of MLL activity by disruption of its interaction with WDR5. Biochem. J., 449, 2013
5CEH	Structure of histone lysine demethylase KDM5A in complex with selective inhibitor 分子名称: 7-oxo-5-phenyl-6-(propan-2-yl)-4,7-dihydropyrazolo[1,5-a]pyrimidine-3-carbonitrile, Lysine-specific demethylase 5A, NICKEL (II) ION, ... 著者 Kiefer, J.R, Vinogradova, M. 登録日 2015-07-06 公開日 2016-05-18 最終更新日 2017-11-22 実験手法 X-RAY DIFFRACTION (3.14 Å) 主引用文献 An inhibitor of KDM5 demethylases reduces survival of drug-tolerant cancer cells. Nat.Chem.Biol., 12, 2016
3QZV	Crystal Structure of BPTF PHD-linker-bromo in complex with histone H4K12ac peptide 分子名称: Histone H4, Nucleosome-remodeling factor subunit BPTF, ZINC ION 著者 Li, H, Ruthenburg, A.J, Patel, D.J. 登録日 2011-03-07 公開日 2011-06-01 最終更新日 2023-12-06 実験手法 X-RAY DIFFRACTION (1.999 Å) 主引用文献 Recognition of a Mononucleosomal Histone Modification Pattern by BPTF via Multivalent Interactions. Cell(Cambridge,Mass.), 145, 2011
5A1F	Crystal structure of the catalytic domain of PLU1 in complex with N-oxalylglycine. 分子名称: 1,2-ETHANEDIOL, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, LYSINE-SPECIFIC DEMETHYLASE 5B, ... 著者 Srikannathasan, V, Johansson, C, Strain-Damerell, C, Gileadi, C, Szykowska, A, Kupinska, K, Kopec, J, Krojer, T, Steuber, H, von Delft, F, Burgess-Brown, N.A, Arrowsmith, C.H, Bountra, C, Edwards, A.M, Oppermann, U. 登録日 2015-04-29 公開日 2015-05-06 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Structural Analysis of Human Kdm5B Guides Histone Demethylase Inhibitor Development. Nat.Chem.Biol., 12, 2016
5A1H	Crystal structure of human Spindlin3 分子名称: SPINDLIN-3 著者 Srikannathasan, V, Gileadi, C, Johansson, C, Shrestha, L, Tallon, R, Burgess-Brown, N.A, von Delft, F, Arrowsmith, C.H, Bountra, C, Edwards, A, Oppermann, U. 登録日 2015-04-30 公開日 2015-06-17 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Crystal Structure of Human Spindlin3 To be Published
5A3P	Crystal structure of the catalytic domain of human PLU1 (JARID1B). 分子名称: 1,2-ETHANEDIOL, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, LYSINE-SPECIFIC DEMETHYLASE 5B, ... 著者 Nowak, R, Srikannathasan, V, Johansson, C, Gileadi, C, Tallant, C, Kupinska, K, Strain-Damerell, C, Szykowska, A, von Delft, F, Burgess-Brown, N.A, Arrowsmith, C.H, Bountra, C, Edwards, A.M, Oppermann, U. 登録日 2015-06-02 公開日 2015-06-10 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (2.008 Å) 主引用文献 Structural Analysis of Human Kdm5B Guides Histone Demethylase Inhibitor Development. Nat.Chem.Biol., 12, 2016
5D6W	Crystal structure of double tudor domain of human lysine demethylase KDM4A 分子名称: Lysine-specific demethylase 4A, S,R MESO-TARTARIC ACID 著者 Wang, F, Su, Z, Denu, J.M, Phillips Jr, G.N, Enzyme Discovery for Natural Product Biosynthesis (NatPro) 登録日 2015-08-13 公開日 2015-11-25 最終更新日 2024-03-06 実験手法 X-RAY DIFFRACTION (1.992 Å) 主引用文献 Reader domain specificity and lysine demethylase-4 family function. Nat Commun, 7, 2016
4LJN	Crystal Structure of MOZ double PHD finger 分子名称: Histone acetyltransferase KAT6A, ZINC ION 著者 Dreveny, I, Deeves, S.E, Yue, B, Heery, D.M. 登録日 2013-07-05 公開日 2013-10-16 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (3 Å) 主引用文献 The double PHD finger domain of MOZ/MYST3 induces alpha-helical structure of the histone H3 tail to facilitate acetylation and methylation sampling and modification. Nucleic Acids Res., 42, 2014
4LK9	Crystal Structure of MOZ double PHD finger histone H3 tail complex 分子名称: Histone H3.1, Histone acetyltransferase KAT6A, ZINC ION 著者 Dreveny, I, Deeves, S.E, Yue, B, Heery, D.M. 登録日 2013-07-07 公開日 2013-10-16 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (1.6 Å) 主引用文献 The double PHD finger domain of MOZ/MYST3 induces alpha-helical structure of the histone H3 tail to facilitate acetylation and methylation sampling and modification. Nucleic Acids Res., 42, 2014
5D6X	Crystal structure of double tudor domain of human lysine demethylase KDM4A 分子名称: Lysine-specific demethylase 4A, SULFATE ION 著者 Wang, F, Su, Z, Denu, J.M, Phillips Jr, G.N, Enzyme Discovery for Natural Product Biosynthesis (NatPro) 登録日 2015-08-13 公開日 2015-11-25 最終更新日 2024-03-06 実験手法 X-RAY DIFFRACTION (2.153 Å) 主引用文献 Reader domain specificity and lysine demethylase-4 family function. Nat Commun, 7, 2016

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