Crystal structure of double tudor domain of human lysine demethylase KDM4A

Summary for 5D6W

Related5D6X 5D6Y
DescriptorLysine-specific demethylase 4A, S,R MESO-TARTARIC ACID (3 entities in total)
Functional Keywordsdouble tudor domain, reader domain, structural genomics, psi-2, protein structure initiative, enzyme discovery for natural product biosynthesis, natpro, oxidoreductase
Biological sourceHomo sapiens (Human)
Cellular locationNucleus  O75164
Total number of polymer chains4
Total molecular weight55508.87
Wang, F.,Su, Z.,Denu, J.M.,Phillips Jr., G.N.,Enzyme Discovery for Natural Product Biosynthesis (NatPro) (deposition date: 2015-08-13, release date: 2015-11-25, Last modification date: 2017-09-20)
Primary citation
Su, Z.,Wang, F.,Lee, J.H.,Stephens, K.E.,Papazyan, R.,Voronina, E.,Krautkramer, K.A.,Raman, A.,Thorpe, J.J.,Boersma, M.D.,Kuznetsov, V.I.,Miller, M.D.,Taverna, S.D.,Phillips, G.N.,Denu, J.M.
Reader domain specificity and lysine demethylase-4 family function.
Nat Commun, 7:13387-13387, 2016
PubMed: 27841353 (PDB entries with the same primary citation)
DOI: 10.1038/ncomms13387
MImport into Mendeley
Experimental method

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.197700.5%0MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution

More Asymmetric unit images

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Molmil generated image of 5d6w
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