5Z58
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![BU of 5z58 by Molmil](/molmil-images/mine/5z58) | Cryo-EM structure of a human activated spliceosome (early Bact) at 4.9 angstrom. | 分子名称: | 116 kDa U5 small nuclear ribonucleoprotein component, BUD13 homolog, Cell division cycle 5-like protein, ... | 著者 | Zhang, X, Yan, C, Zhan, X, Li, L, Lei, J, Shi, Y. | 登録日 | 2018-01-17 | 公開日 | 2018-09-19 | 最終更新日 | 2020-10-14 | 実験手法 | ELECTRON MICROSCOPY (4.9 Å) | 主引用文献 | Structure of the human activated spliceosome in three conformational states. Cell Res., 28, 2018
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5B7A
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8RX0
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![BU of 8rx0 by Molmil](/molmil-images/mine/8rx0) | (NEDD8)-CRL2VHL-MZ1-Brd4BD2-Ub(G76S, K48C)-UBE2R1(C93K, S138C, C191S, C223S)-Ub | 分子名称: | (2~{S},4~{R})-1-[(2~{S})-2-[2-[2-[2-[2-[2-[(9~{S})-7-(4-chlorophenyl)-4,5,13-trimethyl-3-thia-1,8,11,12-tetrazatricyclo[8.3.0.0^{2,6}]trideca-2(6),4,7,10,12-pentaen-9-yl]ethanoylamino]ethoxy]ethoxy]ethoxy]ethanoylamino]-3,3-dimethyl-butanoyl]-~{N}-[[4-(4-methyl-2,3-dihydro-1,3-thiazol-5-yl)phenyl]methyl]-4-oxidanyl-pyrrolidine-2-carboxamide, Cullin-2, Elongin-B, ... | 著者 | Crowe, C, Nakasone, M.A. | 登録日 | 2024-02-05 | 公開日 | 2024-03-06 | 実験手法 | ELECTRON MICROSCOPY (3.7 Å) | 主引用文献 | (NEDD8)-CRL2VHL-MZ1-Brd4BD2-Ub(G76S, K48C)-UBE2R1(C93K, S138C, C191S, C223S)-Ub To Be Published
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7S0Y
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![BU of 7s0y by Molmil](/molmil-images/mine/7s0y) | Structures of TcdB in complex with Cdc42 | 分子名称: | Cell division control protein 42 homolog, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ... | 著者 | Zheng, L, Rongsheng, J, Peng, C. | 登録日 | 2021-08-31 | 公開日 | 2021-09-08 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (2.79 Å) | 主引用文献 | Structural basis for selective modification of Rho and Ras GTPases by Clostridioides difficile toxin B. Sci Adv, 7, 2021
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7ZV2
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![BU of 7zv2 by Molmil](/molmil-images/mine/7zv2) | HUMAN PRMT5:MEP50 Crystal Structure With MTA and Fragment Bound | 分子名称: | 5'-DEOXY-5'-METHYLTHIOADENOSINE, GLYCEROL, Methylosome protein 50, ... | 著者 | Ahmad, M.U, Koelmel, W, Arkhipova, V, Lawson, J.D, Smith, C.R, Gunn, R.J. | 登録日 | 2022-05-13 | 公開日 | 2022-10-19 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (2.01 Å) | 主引用文献 | Fragment optimization and elaboration strategies - the discovery of two lead series of PRMT5/MTA inhibitors from five fragment hits. Rsc Med Chem, 13, 2022
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7ZVL
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![BU of 7zvl by Molmil](/molmil-images/mine/7zvl) | HUMAN PRMT5:MEP50 Crystal Structure With MTA and Fragment Bound | 分子名称: | 5'-DEOXY-5'-METHYLTHIOADENOSINE, CHLORIDE ION, GLYCEROL, ... | 著者 | Ahmad, M.U, Koelmel, W, Arkhipova, V, Lawson, J.D, Smith, C.R, Gunn, R.J. | 登録日 | 2022-05-16 | 公開日 | 2022-10-19 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (2.39 Å) | 主引用文献 | Fragment optimization and elaboration strategies - the discovery of two lead series of PRMT5/MTA inhibitors from five fragment hits. Rsc Med Chem, 13, 2022
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7ZUU
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![BU of 7zuu by Molmil](/molmil-images/mine/7zuu) | HUMAN PRMT5:MEP50 Crystal Structure With MTA and Fragment Bound | 分子名称: | 5'-DEOXY-5'-METHYLTHIOADENOSINE, GLYCEROL, Methylosome protein 50, ... | 著者 | Ahmad, M.U, Koelmel, W, Arkhipova, V, Lawson, J.D, Smith, C.R, Gunn, R.J. | 登録日 | 2022-05-13 | 公開日 | 2022-10-19 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (2.09 Å) | 主引用文献 | Fragment optimization and elaboration strategies - the discovery of two lead series of PRMT5/MTA inhibitors from five fragment hits. Rsc Med Chem, 13, 2022
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7ZUP
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![BU of 7zup by Molmil](/molmil-images/mine/7zup) | Human PRMT5:MEP50 structure with Fragment (Example 18) and MTA Bound | 分子名称: | 3-ethylimidazo[4,5-b]pyridin-2-amine, 5'-DEOXY-5'-METHYLTHIOADENOSINE, GLYCEROL, ... | 著者 | Ahmad, M.U, Koelmel, W, Arkhipova, V, Lawson, J.D, Smith, C.R, Gunn, R.J. | 登録日 | 2022-05-12 | 公開日 | 2022-10-19 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (2.01 Å) | 主引用文献 | Fragment optimization and elaboration strategies - the discovery of two lead series of PRMT5/MTA inhibitors from five fragment hits. Rsc Med Chem, 13, 2022
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7ZUQ
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![BU of 7zuq by Molmil](/molmil-images/mine/7zuq) | HUMAN PRMT5:MEP50 Crystal Structure With MTA and Fragment Bound | 分子名称: | 5'-DEOXY-5'-METHYLTHIOADENOSINE, GLYCEROL, Methylosome protein 50, ... | 著者 | Ahmad, M.U, Koelmel, W, Arkhipova, V, Lawson, J.D, Smith, C.R, Gunn, R.J. | 登録日 | 2022-05-13 | 公開日 | 2022-10-19 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (2.48 Å) | 主引用文献 | Fragment optimization and elaboration strategies - the discovery of two lead series of PRMT5/MTA inhibitors from five fragment hits. Rsc Med Chem, 13, 2022
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7ZUY
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![BU of 7zuy by Molmil](/molmil-images/mine/7zuy) | HUMAN PRMT5:MEP50 Crystal Structure With MTA and Fragment Bound | 分子名称: | 5'-DEOXY-5'-METHYLTHIOADENOSINE, GLYCEROL, Methylosome protein 50, ... | 著者 | Ahmad, M.U, Koelmel, W, Arkhipova, V, Lawson, J.D, Smith, C.R, Gunn, R.J. | 登録日 | 2022-05-13 | 公開日 | 2022-10-19 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Fragment optimization and elaboration strategies - the discovery of two lead series of PRMT5/MTA inhibitors from five fragment hits. Rsc Med Chem, 13, 2022
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7ZVU
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![BU of 7zvu by Molmil](/molmil-images/mine/7zvu) | HUMAN PRMT5:MEP50 Crystal Structure With MTA and Fragment Bound | 分子名称: | 5'-DEOXY-5'-METHYLTHIOADENOSINE, GLYCEROL, Methylosome protein 50, ... | 著者 | Ahmad, M.U, Koelmel, W, Arkhipova, V, Lawson, J.D, Smith, C.R, Gunn, R.J. | 登録日 | 2022-05-17 | 公開日 | 2022-10-19 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | 主引用文献 | Fragment optimization and elaboration strategies - the discovery of two lead series of PRMT5/MTA inhibitors from five fragment hits. Rsc Med Chem, 13, 2022
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7QXW
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![BU of 7qxw by Molmil](/molmil-images/mine/7qxw) | Proteasome-ZFAND5 Complex Z+D state | 分子名称: | 26S protease regulatory subunit 6A, 26S protease regulatory subunit 6B, 26S protease regulatory subunit 7, ... | 著者 | Zhu, Y, Lu, Y. | 登録日 | 2022-01-27 | 公開日 | 2023-02-08 | 実験手法 | ELECTRON MICROSCOPY (4.1 Å) | 主引用文献 | Mechanism of 26S proteasome activation by the 19S-interacting protein ZFAND5 To Be Published
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3JAI
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![BU of 3jai by Molmil](/molmil-images/mine/3jai) | Structure of a mammalian ribosomal termination complex with ABCE1, eRF1(AAQ), and the UGA stop codon | 分子名称: | 18S ribosomal RNA, 28S ribosomal RNA, 5.8S ribosomal RNA, ... | 著者 | Brown, A, Shao, S, Murray, J, Hegde, R.S, Ramakrishnan, V. | 登録日 | 2015-06-10 | 公開日 | 2015-08-12 | 最終更新日 | 2018-07-18 | 実験手法 | ELECTRON MICROSCOPY (3.65 Å) | 主引用文献 | Structural basis for stop codon recognition in eukaryotes. Nature, 524, 2015
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8BTK
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![BU of 8btk by Molmil](/molmil-images/mine/8btk) | Structure of the TRAP complex with the Sec translocon and a translating ribosome | 分子名称: | 18S rRNA, 28S rRNA, 40S ribosomal protein S11, ... | 著者 | Jaskolowski, M, Jomaa, A, Gamerdinger, M, Shrestha, S, Leibundgut, M, Deuerling, E, Ban, N. | 登録日 | 2022-11-29 | 公開日 | 2023-05-24 | 最終更新日 | 2024-04-24 | 実験手法 | ELECTRON MICROSCOPY (3.5 Å) | 主引用文献 | Molecular basis of the TRAP complex function in ER protein biogenesis. Nat.Struct.Mol.Biol., 30, 2023
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4V8Z
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![BU of 4v8z by Molmil](/molmil-images/mine/4v8z) | Cryo-EM reconstruction of the 80S-eIF5B-Met-itRNAMet Eukaryotic Translation Initiation Complex | 分子名称: | 18S RIBOSOMAL RNA, 25S RIBOSOMAL RNA, 40S RIBOSOMAL PROTEIN S0-A, ... | 著者 | Fernandez, I.S, Bai, X.C, Hussain, T, Kelley, A.C, Lorsch, J.R, Ramakrishnan, V, Scheres, S.H.W. | 登録日 | 2013-07-20 | 公開日 | 2014-07-09 | 最終更新日 | 2024-06-26 | 実験手法 | ELECTRON MICROSCOPY (6.6 Å) | 主引用文献 | Molecular architecture of a eukaryotic translational initiation complex. Science, 342, 2013
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2CSX
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![BU of 2csx by Molmil](/molmil-images/mine/2csx) | Crystal structure of Aquifex aeolicus methionyl-tRNA synthetase complexed with tRNA(Met) | 分子名称: | Methionyl-tRNA synthetase, RNA (75-MER) | 著者 | Nakanishi, K, Ogiso, Y, Nakama, T, Fukai, S, Nureki, O, RIKEN Structural Genomics/Proteomics Initiative (RSGI) | 登録日 | 2005-05-23 | 公開日 | 2005-09-20 | 最終更新日 | 2024-03-13 | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | 主引用文献 | Structural basis for anticodon recognition by methionyl-tRNA synthetase. Nat.Struct.Mol.Biol., 12, 2005
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2CT8
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![BU of 2ct8 by Molmil](/molmil-images/mine/2ct8) | Crystal structure of Aquifex aeolicus methionyl-tRNA synthetase complexed with tRNA(Met) and methionyl-adenylate anologue | 分子名称: | 5'-O-[(L-METHIONYL)-SULPHAMOYL]ADENOSINE, Methionyl-tRNA synthetase, RNA (74-MER) | 著者 | Nakanishi, K, Ogiso, Y, Nakama, T, Fukai, S, Nureki, O, RIKEN Structural Genomics/Proteomics Initiative (RSGI) | 登録日 | 2005-05-23 | 公開日 | 2005-09-20 | 最終更新日 | 2024-03-13 | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | 主引用文献 | Structural basis for anticodon recognition by methionyl-tRNA synthetase. Nat.Struct.Mol.Biol., 12, 2005
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2D6F
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2IY5
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![BU of 2iy5 by Molmil](/molmil-images/mine/2iy5) | PHENYLALANYL-TRNA SYNTHETASE FROM THERMUS THERMOPHILUS complexed with tRNA and a phenylalanyl-adenylate analog | 分子名称: | ADENOSINE-5'-[PHENYLALANINOL-PHOSPHATE], MAGNESIUM ION, PHENYLALANYL-TRNA SYNTHETASE ALPHA CHAIN, ... | 著者 | Moor, N, Kotik-Kogan, O, Tworowski, D, Sukhanova, M, Safro, M. | 登録日 | 2006-07-12 | 公開日 | 2006-09-06 | 最終更新日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (3.1 Å) | 主引用文献 | The crystal structure of the ternary complex of phenylalanyl-tRNA synthetase with tRNAPhe and a phenylalanyl-adenylate analogue reveals a conformational switch of the CCA end. Biochemistry, 45, 2006
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3OJ4
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4RVZ
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![BU of 4rvz by Molmil](/molmil-images/mine/4rvz) | Crystal structure of tRNA fluorescent labeling enzyme | 分子名称: | MAGNESIUM ION, N-(4-aminobutyl)-2-azidoacetamide, PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER, ... | 著者 | Dong, J, Li, F, Wang, J, Gong, W. | 登録日 | 2014-11-29 | 公開日 | 2015-03-11 | 最終更新日 | 2024-04-03 | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | 主引用文献 | A covalent approach for site-specific RNA labeling in Mammalian cells. Angew.Chem.Int.Ed.Engl., 54, 2015
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8SCB
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![BU of 8scb by Molmil](/molmil-images/mine/8scb) | Terminating ribosome with SRI-41315 | 分子名称: | (2S,4aS)-2-cyclobutyl-10-methyl-3-phenyl-2,10-dihydropyrimido[4,5-b]quinoline-4,5(3H,4aH)-dione, 18S_rRNA, 28S_rRNA, ... | 著者 | Yip, M.C.J, Coelho, J.P.L, Oltion, K, Tauton, J, Shao, S. | 登録日 | 2023-04-05 | 公開日 | 2023-12-27 | 最終更新日 | 2024-07-17 | 実験手法 | ELECTRON MICROSCOPY (2.5 Å) | 主引用文献 | The eRF1 degrader SRI-41315 acts as a molecular glue at the ribosomal decoding center. Nat.Chem.Biol., 20, 2024
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8RWZ
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![BU of 8rwz by Molmil](/molmil-images/mine/8rwz) | Open non-crosslinked structure Brd4BD2-MZ1-(NEDD8)-CRL2VHL | 分子名称: | (2~{S},4~{R})-1-[(2~{S})-2-[2-[2-[2-[2-[2-[(9~{S})-7-(4-chlorophenyl)-4,5,13-trimethyl-3-thia-1,8,11,12-tetrazatricyclo[8.3.0.0^{2,6}]trideca-2(6),4,7,10,12-pentaen-9-yl]ethanoylamino]ethoxy]ethoxy]ethoxy]ethanoylamino]-3,3-dimethyl-butanoyl]-~{N}-[[4-(4-methyl-2,3-dihydro-1,3-thiazol-5-yl)phenyl]methyl]-4-oxidanyl-pyrrolidine-2-carboxamide, Bromodomain-containing protein 4, Cullin-2, ... | 著者 | Ciulli, A, Crowe, C, Nakacone, M.A. | 登録日 | 2024-02-05 | 公開日 | 2024-03-06 | 実験手法 | ELECTRON MICROSCOPY (4 Å) | 主引用文献 | Open non-crosslinked structure Brd4BD2-MZ1-(NEDD8)-CRL2VHL To Be Published
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1OBH
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![BU of 1obh by Molmil](/molmil-images/mine/1obh) | LEUCYL-TRNA SYNTHETASE FROM THERMUS THERMOPHILUS COMPLEXED WITH A PRE-TRANSFER EDITING SUBSTRATE ANALOGUE IN BOTH SYNTHETIC ACTIVE SITE AND EDITING SITE | 分子名称: | LEUCYL-TRNA SYNTHETASE, MERCURY (II) ION, NORVALINE, ... | 著者 | Cusack, S, Yaremchuk, A, Tukalo, M. | 登録日 | 2003-01-31 | 公開日 | 2003-05-09 | 最終更新日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Structural and Mechanistic Basis of Pre- and Posttransfer Editing by Leucyl-tRNA Synthetase Mol.Cell, 11, 2003
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2HLW
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![BU of 2hlw by Molmil](/molmil-images/mine/2hlw) | Solution Structure of the Human Ubiquitin-conjugating Enzyme Variant Uev1a | 分子名称: | Ubiquitin-conjugating enzyme E2 variant 1 | 著者 | Hau, D.D, Lewis, M.J, Saltibus, L.F, Pastushok, L, Xiao, W, Spyracopoulos, L. | 登録日 | 2006-07-10 | 公開日 | 2006-09-05 | 最終更新日 | 2024-05-29 | 実験手法 | SOLUTION NMR | 主引用文献 | Structure and interactions of the ubiquitin-conjugating enzyme variant human uev1a: implications for enzymatic synthesis of polyubiquitin chains(,). Biochemistry, 45, 2006
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