7ZVL

HUMAN PRMT5:MEP50 Crystal Structure With MTA and Fragment Bound

Summary for 7ZVL

• Entry DOI: 10.2210/pdb7zvl/pdb
• Descriptor: Protein arginine N-methyltransferase 5, Methylosome protein 50, 5'-DEOXY-5'-METHYLTHIOADENOSINE, ... (7 entities in total)
• Functional Keywords: mtap, methyl transferase, fragment-based lead discovery, fbdd, transferase
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 2
• Total formula weight: 112143.01

Authors

Ahmad, M.U.,Koelmel, W.,Arkhipova, V.,Lawson, J.D.,Smith, C.R.,Gunn, R.J. (deposition date: 2022-05-16, release date: 2022-10-19, Last modification date: 2024-01-31)

• Primary citation: Smith, C.R.,Kulyk, S.,Ahmad, M.U.D.,Arkhipova, V.,Christensen, J.G.,Gunn, R.J.,Ivetac, A.,Ketcham, J.M.,Kuehler, J.,Lawson, J.D.,Thomas, N.C.,Wang, X.,Marx, M.A.; Fragment optimization and elaboration strategies - the discovery of two lead series of PRMT5/MTA inhibitors from five fragment hits.; Rsc Med Chem, 13:1549-1564, 2022; PubMed: 36545438; DOI: 10.1039/d2md00163b

Experimental method

X-RAY DIFFRACTION (2.39 Å)