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3EWZ
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human orotidyl-5'-monophosphate decarboxylase in complex with 5-cyano-UMP
分子名称: 5-CYANO-URIDINE-5'-MONOPHOSPHATE, Orotidine-5'-phosphate decarboxylase, SULFATE ION
著者Heinrich, D, Diederichsen, U, Rudolph, M.
登録日2008-10-16
公開日2009-04-07
最終更新日2023-12-27
実験手法X-RAY DIFFRACTION (1.4 Å)
主引用文献Lys314 is a nucleophile in non-classical reactions of orotidine-5'-monophosphate decarboxylase
Chemistry, 15, 2009
3F1Q
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Human dihydroorotate dehydrogenase in complex with a leflunomide derivative inhibitor 1
分子名称: (2Z)-N-biphenyl-4-yl-2-cyano-3-hydroxybut-2-enamide, ACETIC ACID, Dihydroorotate dehydrogenase, ...
著者Heikkila, T, Davies, M, McConkey, G.A, Fishwick, C.W.G, Parsons, M.R, Johnson, A.P.
登録日2008-10-28
公開日2009-06-09
最終更新日2023-11-01
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Structure-based design, synthesis, and characterization of inhibitors of human and Plasmodium falciparum dihydroorotate dehydrogenases
J.Med.Chem., 52, 2009
7AM9
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OMPD-domain of human UMPS in complex with the substrate OMP at 0.99 Angstroms resolution
分子名称: GLYCEROL, OROTIDINE-5'-MONOPHOSPHATE, SULFATE ION, ...
著者Tittmann, K, Rindfleisch, S, Krull, M.
登録日2020-10-08
公開日2021-11-03
最終更新日2024-01-31
実験手法X-RAY DIFFRACTION (0.99 Å)
主引用文献Ground-state destabilization by electrostatic repulsion is not a driving force in orotidine-5-monophosphate decarboxylase catalysis
Nat Catal, 5, 2022
7ASQ
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Orotidine 5'-monophosphate decarboxylase-domain of human UMPS in complex with the reaction product UMP at 0.95 Angstrom resolution
分子名称: GLYCEROL, SODIUM ION, SULFATE ION, ...
著者Rindfleisch, S, Rabe von Pappenheim, F.
登録日2020-10-28
公開日2021-11-24
最終更新日2024-01-31
実験手法X-RAY DIFFRACTION (0.95 Å)
主引用文献Ground-state destabilization by electrostatic repulsion is not a driving force in orotidine-5-monophosphate decarboxylase catalysis
Nat Catal, 5, 2022
6VND
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Quaternary Complex of human dihydroorotate dehydrogenase (DHODH) with flavin mononucleotide (FMN), orotic acid and AG-636
分子名称: 1-methyl-5-(2'-methyl[1,1'-biphenyl]-4-yl)-1H-benzotriazole-7-carboxylic acid, ACETATE ION, CHLORIDE ION, ...
著者Padyana, A, Jin, L.
登録日2020-01-29
公開日2020-11-04
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (1.97 Å)
主引用文献Selective Vulnerability to Pyrimidine Starvation in Hematologic Malignancies Revealed by AG-636, a Novel Clinical-Stage Inhibitor of Dihydroorotate Dehydrogenase.
Mol.Cancer Ther., 19, 2020
6YB9
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Human octameric PAICS in complex with SAICAR, AMP-PNP, and magnesium
分子名称: (2~{S})-2-[[5-azanyl-1-[(2~{R},3~{R},4~{S},5~{R})-3,4-bis(oxidanyl)-5-(phosphonooxymethyl)oxolan-2-yl]imidazol-4-yl]car bonylamino]butanedioic acid, 1,2-ETHANEDIOL, MAGNESIUM ION, ...
著者Skerlova, J, Unterlass, J, Gottmann, M, Homan, E, Helleday, T, Jemth, A.S, Stenmark, P.
登録日2020-03-16
公開日2020-07-08
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (2.406 Å)
主引用文献Crystal structures of human PAICS reveal substrate and product binding of an emerging cancer target.
J.Biol.Chem., 295, 2020
4RR4
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Crystal structure of human dihydroorotate dehydrogenase (DHODH) with DH03A367
分子名称: 2-chloro-N-[3-(4-{[(2Z)-2-cyano-3-cyclopropyl-3-hydroxyprop-2-enoyl]amino}phenoxy)phenyl]-4-methyl-1,3-thiazole-5-carboxamide, Dihydroorotate dehydrogenase (quinone), mitochondrial, ...
著者Zhu, L, Ren, X, Zhu, J, Li, H.
登録日2014-11-06
公開日2015-11-25
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (2.38 Å)
主引用文献Crystal structure of human dihydroorotate dehydrogenase (DHODH) with DH03A367
TO BE PUBLISHED
4RKA
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Crystal structure of human dihydroorotate dehydrogenase (DHODH) with DH03A347
分子名称: 2-{[5-(naphthalen-1-ylmethyl)-4-oxo-4H-1lambda~4~,3-thiazol-2-yl]amino}benzoic acid, Dihydroorotate dehydrogenase (quinone), mitochondrial, ...
著者Zhu, L, Ren, X, Zhu, J, Li, H.
登録日2014-10-12
公開日2015-11-11
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (2.71 Å)
主引用文献Crystal structure of human dihydroorotate dehydrogenase (DHODH) with DH03A347
TO BE PUBLISHED
4RLI
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Crystal structure of human dihydroorotate dehydrogenase (DHODH) with DH03A048
分子名称: Dihydroorotate dehydrogenase (quinone), mitochondrial, FLAVIN MONONUCLEOTIDE, ...
著者Zhu, L, Ren, X, Zhu, J, Li, H.
登録日2014-10-17
公開日2015-11-04
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Crystal structure of human dihydroorotate dehydrogenase (DHODH) with DH03A048
TO BE PUBLISHED
4RK8
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Crystal structure of human dihydroorotate dehydrogenase (DHODH) with DH03A356
分子名称: 5-fluoro-2-{[(5Z)-5-(naphthalen-1-ylmethylidene)-4-oxo-4,5-dihydro-1,3-thiazol-2-yl]amino}benzoic acid, Dihydroorotate dehydrogenase (quinone), mitochondrial, ...
著者Zhu, L, Ren, X, Zhu, J, Li, H.
登録日2014-10-12
公開日2015-11-11
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (2.22 Å)
主引用文献Crystal structure of human dihydroorotate dehydrogenase (DHODH) with DH03A356
TO BE PUBLISHED
2VD6
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Human adenylosuccinate lyase in complex with its substrate N6-(1,2- Dicarboxyethyl)-AMP, and its products AMP and fumarate.
分子名称: 2-[9-(3,4-DIHYDROXY-5-PHOSPHONOOXYMETHYL-TETRAHYDRO-FURAN-2-YL)-9H-PURIN-6-YLAMINO]-SUCCINIC ACID, ADENOSINE MONOPHOSPHATE, ADENYLOSUCCINATE LYASE, ...
著者Stenmark, P, Moche, M, Arrowsmith, C, Berglund, H, Busam, R, Collins, R, Dahlgren, L.G, Edwards, A, Flodin, S, Flores, A, Graslund, S, Hammarstrom, M, Hallberg, B.M, Holmberg-schiavone, L, Johansson, I, Kallas, A, Karlberg, T, Kotenyova, T, Lehtio, L, Nilsson, M, Nyman, T, Ogg, D, Persson, C, Sagemark, J, Sundstrom, M, Thorsell, A.G, Tresaugues, L, van den Berg, S, Weigelt, J, Welin, M, Nordlund, P, Structural Genomics Consortium (SGC)
登録日2007-09-30
公開日2007-10-23
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Human Adenylosuccinate Lyase in Complex with its Substrate N6-(1,2-Dicarboxyethyl)-AMP, and its Products AMP and Fumarate.
To be Published
7B1O
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BU of 7b1o by Molmil
Crystal structure of the indoleamine 2,3-dioxygenase 1 (IDO1) in complex with compound 22
分子名称: 4-chloranyl-N-[(1R)-1-[(1S,5R)-3-quinolin-4-yloxy-6-bicyclo[3.1.0]hexanyl]propyl]benzamide, Indoleamine 2,3-dioxygenase 1
著者Lammens, A, Krapp, S, Lewis, R.T, Hamilton, M.M.
登録日2020-11-25
公開日2021-09-29
実験手法X-RAY DIFFRACTION (2.58 Å)
主引用文献Discovery of IACS-9779 and IACS-70465 as Potent Inhibitors Targeting Indoleamine 2,3-Dioxygenase 1 (IDO1) Apoenzyme.
J.Med.Chem., 64, 2021
4WML
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BU of 4wml by Molmil
Crystal structure of Saccharomyces cerevisiae OMP synthase in complex with PRP(CH2)P
分子名称: 1-O-[(R)-hydroxy(phosphonomethyl)phosphoryl]-5-O-phosphono-alpha-D-ribofuranose, MAGNESIUM ION, Orotate phosphoribosyltransferase 1
著者Bang, M.B, Molich, U, Hansen, M.R, Grubmeyer, C, Harris, P.
登録日2014-10-09
公開日2015-12-23
最終更新日2024-01-10
実験手法X-RAY DIFFRACTION (1.73 Å)
主引用文献Crystal structure of Saccharomyces cerevisia OMP synthase in complex with PRP(CH2)P
To Be Published
4WN3
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BU of 4wn3 by Molmil
Crystal structure of Saccharomyces cerevisiae OMP synthase in complex with PRP(NH)P
分子名称: MAGNESIUM ION, Orotate phosphoribosyltransferase 1, [[[(2R,3R,4S,5R)-3,4-bis(oxidanyl)-5-(phosphonooxymethyl)oxolan-2-yl]oxy-oxidanyl-phosphoryl]amino]phosphonic acid
著者Bang, M.B, Molich, U, Hansen, M.R, Grubmeyer, C, Harris, P.
登録日2014-10-10
公開日2015-12-23
最終更新日2024-01-10
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Crystal structure of Saccharomyces cerevisiae OMP synthase in complex with PRP(NH)P
To Be Published
4XQ6
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BU of 4xq6 by Molmil
CRYSTAL STRUCTURE OF DIHYDROOROTATE DEHYDROGENSE from MYCOBACTERIUM TUBERCULOSIS
分子名称: CHLORIDE ION, Dihydroorotate dehydrogenase (quinone), FLAVIN MONONUCLEOTIDE, ...
著者Kishor, C, Addlagatta, A.
登録日2015-01-19
公開日2016-01-20
最終更新日2024-03-20
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Crystal structure of Dihydroorotate Dehydrogenase form Mycobacterium Tuberculosis
To Be Published
4YLW
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BU of 4ylw by Molmil
Crystal structure of human dihydroorotate dehydrogenase (DHODH) with No.33 compound
分子名称: Dihydroorotate dehydrogenase (quinone), mitochondrial, FLAVIN MONONUCLEOTIDE, ...
著者Wu, D, Ouyang, P, Lu, W, Huang, J.
登録日2015-03-06
公開日2016-03-09
最終更新日2023-11-08
実験手法X-RAY DIFFRACTION (1.79 Å)
主引用文献Crystal structure of human dihydroorotate dehydrogenase (DHODH) with No.33 compound
To Be Published
5VKW
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BU of 5vkw by Molmil
Crystal structure of adenylosuccinate lyase ADE13 from Candida albicans
分子名称: Adenylosuccinate lyase, CALCIUM ION, CHLORIDE ION, ...
著者Stogios, P.J, Evdokimova, E, Di Leo, R, Savchenko, A, Anderson, W.F, Center for Structural Genomics of Infectious Diseases (CSGID)
登録日2017-04-24
公開日2017-05-24
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (1.998 Å)
主引用文献Crystal structure of adenylosuccinate lyase ADE13 from Candida albicans
To Be Published
5XFV
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BU of 5xfv by Molmil
Crystal structures of FMN-bound form of dihydroorotate dehydrogenase from Trypanosoma brucei
分子名称: Dihydroorotate dehydrogenase (fumarate), FLAVIN MONONUCLEOTIDE, MALONATE ION
著者Kubota, T, Tani, O, Yamaguchi, T, Namatame, I, Sakashita, H, Furukawa, K, Yamasaki, K.
登録日2017-04-11
公開日2018-04-25
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (1.79 Å)
主引用文献Crystal structures of FMN-bound and FMN-free forms of dihydroorotate dehydrogenase fromTrypanosoma brucei.
FEBS Open Bio, 8, 2018
5XFW
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Crystal structures of FMN-free form of dihydroorotate dehydrogenase from Trypanosoma brucei
分子名称: Dihydroorotate dehydrogenase (fumarate), MALONATE ION
著者Kubota, T, Tani, O, Yamaguchi, T, Namatame, I, Sakashita, H, Furukawa, K, Yamasaki, K.
登録日2017-04-11
公開日2018-04-25
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (1.6 Å)
主引用文献Crystal structures of FMN-bound and FMN-free forms of dihydroorotate dehydrogenase fromTrypanosoma brucei.
FEBS Open Bio, 8, 2018
5VMQ
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BU of 5vmq by Molmil
STRUCTURE OF THE R105A MUTANT CATALYTIC TRIMER OF ESCHERICHIA COLI ASPARTATE TRANSCARBAMOYLASE AT 2.0-A RESOLUTION
分子名称: Aspartate carbamoyltransferase, CALCIUM ION, CHLORIDE ION
著者Beernink, P.T, Endrizzi, J.A.
登録日2017-04-28
公開日2017-05-24
最終更新日2024-03-13
実験手法X-RAY DIFFRACTION (2.012 Å)
主引用文献Charge neutralization in the active site of the catalytic trimer of aspartate transcarbamoylase promotes diverse structural changes.
Protein Sci., 26, 2017
8VHM
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Structure of DHODH in Complex with Fragment 2
分子名称: ACETATE ION, CHLORIDE ION, Dihydroorotate dehydrogenase (quinone), ...
著者Shaffer, P.L.
登録日2024-01-02
公開日2024-04-03
実験手法X-RAY DIFFRACTION (2.26 Å)
主引用文献Discovery of Alternative Binding Poses through Fragment-Based Identification of DHODH Inhibitors.
Acs Med.Chem.Lett., 15, 2024
8YHR
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BU of 8yhr by Molmil
DHODH in complex with furocoumavirin
分子名称: 4-methyl-8-[(S)-oxidanyl(phenyl)methyl]-9-phenyl-furo[2,3-h]chromen-2-one, ACETATE ION, Dihydroorotate dehydrogenase (quinone), ...
著者Hara, K, Okumura, H, Nakahara, M, Sato, M, Hashimoto, H, Osada, H, Watanabe, K.
登録日2024-02-28
公開日2024-05-22
最終更新日2024-06-05
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献Structural and Functional Analyses of Inhibition of Human Dihydroorotate Dehydrogenase by Antiviral Furocoumavirin.
Biochemistry, 63, 2024
8VHL
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Structure of DHODH in Complex with Ligand 17
分子名称: ACETATE ION, Dihydroorotate dehydrogenase (quinone), mitochondrial, ...
著者Shaffer, P.L.
登録日2024-01-02
公開日2024-04-03
実験手法X-RAY DIFFRACTION (1.93 Å)
主引用文献Discovery of Alternative Binding Poses through Fragment-Based Identification of DHODH Inhibitors.
Acs Med.Chem.Lett., 15, 2024
5H2Z
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BU of 5h2z by Molmil
Crystal structure of Human Dihydroorotate Dehydrogenase (DHODH) with 7GF
分子名称: ACETATE ION, Dihydroorotate dehydrogenase (quinone), mitochondrial, ...
著者Wu, D, Huang, J.
登録日2016-10-19
公開日2017-03-01
最終更新日2023-11-08
実験手法X-RAY DIFFRACTION (1.58 Å)
主引用文献Crystal structure of Human Dihydroorotate Dehydrogenase (DHODH) with 7GF
To Be Published
1VQT
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Crystal structure of Orotidine 5'-phosphate decarboxylase (TM0332) from Thermotoga maritima at 2.00 A resolution
分子名称: 1,2-ETHANEDIOL, Orotidine 5'-phosphate decarboxylase
著者Joint Center for Structural Genomics (JCSG)
登録日2005-01-04
公開日2005-01-18
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Crystal structure of Orotidine 5'-phosphate decarboxylase (TM0332) from Thermotoga maritima at 2.00 A resolution
To be published

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