6YB9

Human octameric PAICS in complex with SAICAR, AMP-PNP, and magnesium

Summary for 6YB9

• Entry DOI: 10.2210/pdb6yb9/pdb
• Related: 6YB8
• Descriptor: Multifunctional protein ADE2, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, (2~{S})-2-[[5-azanyl-1-[(2~{R},3~{R},4~{S},5~{R})-3,4-bis(oxidanyl)-5-(phosphonooxymethyl)oxolan-2-yl]imidazol-4-yl]car bonylamino]butanedioic acid, ... (6 entities in total)
• Functional Keywords: de novo purine biosynthesis, nucleotide metabolism, cancer target, biosynthetic protein
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 2
• Total formula weight: 96660.79

Authors

Skerlova, J.,Unterlass, J.,Gottmann, M.,Homan, E.,Helleday, T.,Jemth, A.S.,Stenmark, P. (deposition date: 2020-03-16, release date: 2020-07-08, Last modification date: 2024-01-24)

• Primary citation: Skerlova, J.,Unterlass, J.,Gottmann, M.,Marttila, P.,Homan, E.,Helleday, T.,Jemth, A.S.,Stenmark, P.; Crystal structures of human PAICS reveal substrate and product binding of an emerging cancer target.; J.Biol.Chem., 295:11656-11668, 2020; PubMed: 32571877; DOI: 10.1074/jbc.RA120.013695

Experimental method

X-RAY DIFFRACTION (2.406 Å)