6YB9
Human octameric PAICS in complex with SAICAR, AMP-PNP, and magnesium
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004638 | molecular_function | phosphoribosylaminoimidazole carboxylase activity |
| A | 0004639 | molecular_function | phosphoribosylaminoimidazolesuccinocarboxamide synthase activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005524 | molecular_function | ATP binding |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005829 | cellular_component | cytosol |
| A | 0006164 | biological_process | purine nucleotide biosynthetic process |
| A | 0006177 | biological_process | GMP biosynthetic process |
| A | 0006189 | biological_process | 'de novo' IMP biosynthetic process |
| A | 0009113 | biological_process | purine nucleobase biosynthetic process |
| A | 0016020 | cellular_component | membrane |
| A | 0016831 | molecular_function | carboxy-lyase activity |
| A | 0016874 | molecular_function | ligase activity |
| A | 0042802 | molecular_function | identical protein binding |
| A | 0043727 | molecular_function | 5-amino-4-imidazole carboxylate lyase activity |
| A | 0044208 | biological_process | 'de novo' AMP biosynthetic process |
| A | 0045296 | molecular_function | cadherin binding |
| A | 0070062 | cellular_component | extracellular exosome |
| A | 0097294 | biological_process | 'de novo' XMP biosynthetic process |
| B | 0004638 | molecular_function | phosphoribosylaminoimidazole carboxylase activity |
| B | 0004639 | molecular_function | phosphoribosylaminoimidazolesuccinocarboxamide synthase activity |
| B | 0005515 | molecular_function | protein binding |
| B | 0005524 | molecular_function | ATP binding |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005829 | cellular_component | cytosol |
| B | 0006164 | biological_process | purine nucleotide biosynthetic process |
| B | 0006177 | biological_process | GMP biosynthetic process |
| B | 0006189 | biological_process | 'de novo' IMP biosynthetic process |
| B | 0009113 | biological_process | purine nucleobase biosynthetic process |
| B | 0016020 | cellular_component | membrane |
| B | 0016831 | molecular_function | carboxy-lyase activity |
| B | 0016874 | molecular_function | ligase activity |
| B | 0042802 | molecular_function | identical protein binding |
| B | 0043727 | molecular_function | 5-amino-4-imidazole carboxylate lyase activity |
| B | 0044208 | biological_process | 'de novo' AMP biosynthetic process |
| B | 0045296 | molecular_function | cadherin binding |
| B | 0070062 | cellular_component | extracellular exosome |
| B | 0097294 | biological_process | 'de novo' XMP biosynthetic process |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 17 |
| Details | binding site for residue ANP A 501 |
| Chain | Residue |
| A | TYR14 |
| A | MET93 |
| A | LYS131 |
| A | ASP207 |
| A | MG507 |
| A | HOH602 |
| A | HOH617 |
| A | HOH658 |
| A | HOH699 |
| A | GLY16 |
| A | LYS17 |
| A | THR18 |
| A | LYS19 |
| A | VAL21 |
| A | LEU33 |
| A | PRO89 |
| A | CYS91 |
| site_id | AC2 |
| Number of Residues | 20 |
| Details | binding site for residue OK8 A 502 |
| Chain | Residue |
| A | LYS17 |
| A | THR40 |
| A | GLY42 |
| A | GLU97 |
| A | ARG101 |
| A | GLY106 |
| A | SER107 |
| A | ASP189 |
| A | LYS191 |
| A | ASP212 |
| A | SER213 |
| A | TRP214 |
| A | ARG215 |
| A | LYS228 |
| A | ARG232 |
| A | MG508 |
| A | HOH621 |
| A | HOH686 |
| A | HOH689 |
| A | HOH694 |
| site_id | AC3 |
| Number of Residues | 6 |
| Details | binding site for residue EDO A 503 |
| Chain | Residue |
| A | LYS178 |
| A | GLU263 |
| A | GLY392 |
| A | ASN395 |
| A | HIS396 |
| A | HOH618 |
| site_id | AC4 |
| Number of Residues | 7 |
| Details | binding site for residue EDO A 504 |
| Chain | Residue |
| A | ILE73 |
| A | LYS74 |
| A | ILE164 |
| A | ILE203 |
| A | LEU205 |
| A | ILE411 |
| A | HOH680 |
| site_id | AC5 |
| Number of Residues | 6 |
| Details | binding site for residue EDO A 505 |
| Chain | Residue |
| A | LEU378 |
| A | SER379 |
| A | HOH604 |
| B | LEU366 |
| B | ARG367 |
| B | LEU368 |
| site_id | AC6 |
| Number of Residues | 7 |
| Details | binding site for residue EDO A 506 |
| Chain | Residue |
| A | GLU317 |
| A | GLY318 |
| A | ASP319 |
| A | GLY320 |
| A | HOH648 |
| B | GLU177 |
| B | LYS178 |
| site_id | AC7 |
| Number of Residues | 2 |
| Details | binding site for residue MG A 507 |
| Chain | Residue |
| A | ANP501 |
| A | HOH658 |
| site_id | AC8 |
| Number of Residues | 3 |
| Details | binding site for residue MG A 508 |
| Chain | Residue |
| A | GLU97 |
| A | ASP137 |
| A | OK8502 |
| site_id | AC9 |
| Number of Residues | 6 |
| Details | binding site for residue EDO B 701 |
| Chain | Residue |
| A | GLU177 |
| A | LYS178 |
| A | HOH636 |
| B | GLU317 |
| B | GLY318 |
| B | GLY320 |
| site_id | AD1 |
| Number of Residues | 17 |
| Details | binding site for residue ANP B 702 |
| Chain | Residue |
| B | TYR14 |
| B | GLY16 |
| B | LYS17 |
| B | THR18 |
| B | LYS19 |
| B | VAL21 |
| B | LEU33 |
| B | PRO89 |
| B | CYS91 |
| B | MET93 |
| B | LYS131 |
| B | ASP207 |
| B | MG705 |
| B | HOH805 |
| B | HOH826 |
| B | HOH829 |
| B | HOH890 |
| site_id | AD2 |
| Number of Residues | 19 |
| Details | binding site for residue OK8 B 703 |
| Chain | Residue |
| B | ASP189 |
| B | MET190 |
| B | LYS191 |
| B | ASP212 |
| B | TRP214 |
| B | ARG215 |
| B | LYS228 |
| B | ARG232 |
| B | MG706 |
| B | HOH853 |
| B | HOH865 |
| B | LYS17 |
| B | THR40 |
| B | GLY42 |
| B | GLU97 |
| B | VAL99 |
| B | ARG101 |
| B | GLY106 |
| B | SER107 |
| site_id | AD3 |
| Number of Residues | 3 |
| Details | binding site for residue EDO B 704 |
| Chain | Residue |
| B | SER274 |
| B | THR275 |
| B | HOH867 |
| site_id | AD4 |
| Number of Residues | 2 |
| Details | binding site for residue MG B 705 |
| Chain | Residue |
| B | ANP702 |
| B | HOH826 |
| site_id | AD5 |
| Number of Residues | 4 |
| Details | binding site for residue MG B 706 |
| Chain | Residue |
| B | GLU97 |
| B | ASP137 |
| B | OK8703 |
| B | HOH925 |
Functional Information from PROSITE/UniProt
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:17224163, ECO:0007744|PDB:2H31 |
| Chain | Residue | Details |
| A | SER332 | |
| B | SER332 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | MOD_RES: N-acetylalanine => ECO:0000269|Ref.6, ECO:0007744|PubMed:19413330, ECO:0007744|PubMed:22223895 |
| Chain | Residue | Details |
| A | ALA2 | |
| B | ALA2 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphotyrosine => ECO:0000250|UniProtKB:Q9DCL9 |
| Chain | Residue | Details |
| A | TYR22 | |
| B | TYR22 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:16964243, ECO:0007744|PubMed:17924679, ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:18691976, ECO:0007744|PubMed:19369195, ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:23186163 |
| Chain | Residue | Details |
| A | SER27 | |
| B | SER27 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | MOD_RES: N6-acetyllysine => ECO:0000250|UniProtKB:Q9DCL9 |
| Chain | Residue | Details |
| A | LYS36 | |
| B | LYS36 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:23186163 |
| Chain | Residue | Details |
| A | SER107 | |
| B | SER107 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphothreonine => ECO:0007744|PubMed:18691976, ECO:0007744|PubMed:23186163 |
| Chain | Residue | Details |
| A | THR238 | |
| B | THR238 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 2 |
| Details | MOD_RES: N6-acetyllysine => ECO:0007744|PubMed:19608861 |
| Chain | Residue | Details |
| A | LYS247 | |
| B | LYS247 |
| site_id | SWS_FT_FI9 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163, ECO:0007744|PubMed:24275569 |
| Chain | Residue | Details |
| A | SER274 | |
| B | SER274 |
