6YB8
Human octameric PAICS in complex with CAIR and SAICAR
Summary for 6YB8
Entry DOI | 10.2210/pdb6yb8/pdb |
Related | 6yb9 |
Descriptor | Multifunctional protein ADE2, 5-AMINO-1-(5-O-PHOSPHONO-BETA-D-RIBOFURANOSYL)-1H-IMIDAZOLE-4-CARBOXYLIC ACID, (2~{S})-2-[[5-azanyl-1-[(2~{R},3~{R},4~{S},5~{R})-3,4-bis(oxidanyl)-5-(phosphonooxymethyl)oxolan-2-yl]imidazol-4-yl]car bonylamino]butanedioic acid, ... (6 entities in total) |
Functional Keywords | de novo purine biosynthesis, nucleotide metabolism, cancer target, biosynthetic protein |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 2 |
Total formula weight | 96500.92 |
Authors | Skerlova, J.,Unterlass, J.,Gottmann, M.,Homan, E.,Helleday, T.,Jemth, A.S.,Stenmark, P. (deposition date: 2020-03-16, release date: 2020-07-08, Last modification date: 2024-01-24) |
Primary citation | Skerlova, J.,Unterlass, J.,Gottmann, M.,Marttila, P.,Homan, E.,Helleday, T.,Jemth, A.S.,Stenmark, P. Crystal structures of human PAICS reveal substrate and product binding of an emerging cancer target. J.Biol.Chem., 295:11656-11668, 2020 Cited by PubMed: 32571877DOI: 10.1074/jbc.RA120.013695 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.36 Å) |
Structure validation
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