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6YB8

Human octameric PAICS in complex with CAIR and SAICAR

Summary for 6YB8
Entry DOI10.2210/pdb6yb8/pdb
Related6yb9
DescriptorMultifunctional protein ADE2, 5-AMINO-1-(5-O-PHOSPHONO-BETA-D-RIBOFURANOSYL)-1H-IMIDAZOLE-4-CARBOXYLIC ACID, (2~{S})-2-[[5-azanyl-1-[(2~{R},3~{R},4~{S},5~{R})-3,4-bis(oxidanyl)-5-(phosphonooxymethyl)oxolan-2-yl]imidazol-4-yl]car bonylamino]butanedioic acid, ... (6 entities in total)
Functional Keywordsde novo purine biosynthesis, nucleotide metabolism, cancer target, biosynthetic protein
Biological sourceHomo sapiens (Human)
Total number of polymer chains2
Total formula weight96500.92
Authors
Skerlova, J.,Unterlass, J.,Gottmann, M.,Homan, E.,Helleday, T.,Jemth, A.S.,Stenmark, P. (deposition date: 2020-03-16, release date: 2020-07-08, Last modification date: 2024-01-24)
Primary citationSkerlova, J.,Unterlass, J.,Gottmann, M.,Marttila, P.,Homan, E.,Helleday, T.,Jemth, A.S.,Stenmark, P.
Crystal structures of human PAICS reveal substrate and product binding of an emerging cancer target.
J.Biol.Chem., 295:11656-11668, 2020
Cited by
PubMed: 32571877
DOI: 10.1074/jbc.RA120.013695
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.36 Å)
Structure validation

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