6YB8
Human octameric PAICS in complex with CAIR and SAICAR
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000166 | molecular_function | nucleotide binding |
| A | 0003824 | molecular_function | catalytic activity |
| A | 0004638 | molecular_function | phosphoribosylaminoimidazole carboxylase activity |
| A | 0004639 | molecular_function | phosphoribosylaminoimidazolesuccinocarboxamide synthase activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005524 | molecular_function | ATP binding |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005829 | cellular_component | cytosol |
| A | 0006164 | biological_process | purine nucleotide biosynthetic process |
| A | 0006177 | biological_process | GMP biosynthetic process |
| A | 0006189 | biological_process | 'de novo' IMP biosynthetic process |
| A | 0009113 | biological_process | purine nucleobase biosynthetic process |
| A | 0016020 | cellular_component | membrane |
| A | 0016829 | molecular_function | lyase activity |
| A | 0016831 | molecular_function | carboxy-lyase activity |
| A | 0016874 | molecular_function | ligase activity |
| A | 0042802 | molecular_function | identical protein binding |
| A | 0044208 | biological_process | 'de novo' AMP biosynthetic process |
| A | 0045296 | molecular_function | cadherin binding |
| A | 0070062 | cellular_component | extracellular exosome |
| A | 0097294 | biological_process | 'de novo' XMP biosynthetic process |
| B | 0000166 | molecular_function | nucleotide binding |
| B | 0003824 | molecular_function | catalytic activity |
| B | 0004638 | molecular_function | phosphoribosylaminoimidazole carboxylase activity |
| B | 0004639 | molecular_function | phosphoribosylaminoimidazolesuccinocarboxamide synthase activity |
| B | 0005515 | molecular_function | protein binding |
| B | 0005524 | molecular_function | ATP binding |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005829 | cellular_component | cytosol |
| B | 0006164 | biological_process | purine nucleotide biosynthetic process |
| B | 0006177 | biological_process | GMP biosynthetic process |
| B | 0006189 | biological_process | 'de novo' IMP biosynthetic process |
| B | 0009113 | biological_process | purine nucleobase biosynthetic process |
| B | 0016020 | cellular_component | membrane |
| B | 0016829 | molecular_function | lyase activity |
| B | 0016831 | molecular_function | carboxy-lyase activity |
| B | 0016874 | molecular_function | ligase activity |
| B | 0042802 | molecular_function | identical protein binding |
| B | 0044208 | biological_process | 'de novo' AMP biosynthetic process |
| B | 0045296 | molecular_function | cadherin binding |
| B | 0070062 | cellular_component | extracellular exosome |
| B | 0097294 | biological_process | 'de novo' XMP biosynthetic process |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 14 |
| Details | binding site for residue C2R A 501 |
| Chain | Residue |
| A | SER274 |
| A | GLY334 |
| A | LEU335 |
| A | PRO369 |
| A | SER370 |
| A | HOH649 |
| A | ASP277 |
| A | SER301 |
| A | ALA302 |
| A | HIS303 |
| A | LYS304 |
| A | ALA329 |
| A | GLY330 |
| A | SER332 |
| site_id | AC2 |
| Number of Residues | 21 |
| Details | binding site for residue OK8 A 502 |
| Chain | Residue |
| A | LYS17 |
| A | ALA41 |
| A | GLY42 |
| A | ASN43 |
| A | ARG101 |
| A | GLY106 |
| A | SER107 |
| A | ASP137 |
| A | ASP189 |
| A | MET190 |
| A | LYS191 |
| A | ASP212 |
| A | TRP214 |
| A | ARG215 |
| A | LYS228 |
| A | ARG232 |
| A | IMD503 |
| A | HOH681 |
| A | HOH685 |
| A | HOH689 |
| A | HOH696 |
| site_id | AC3 |
| Number of Residues | 4 |
| Details | binding site for residue IMD A 503 |
| Chain | Residue |
| A | GLU97 |
| A | PHE129 |
| A | OK8502 |
| A | HOH784 |
| site_id | AC4 |
| Number of Residues | 4 |
| Details | binding site for residue EDO A 504 |
| Chain | Residue |
| A | LYS74 |
| A | ILE203 |
| A | ILE411 |
| A | HOH675 |
| site_id | AC5 |
| Number of Residues | 4 |
| Details | binding site for residue EDO A 505 |
| Chain | Residue |
| A | GLU315 |
| A | ASP319 |
| A | HOH752 |
| B | TYR122 |
| site_id | AC6 |
| Number of Residues | 5 |
| Details | binding site for residue EDO A 506 |
| Chain | Residue |
| A | PRO89 |
| A | GLN90 |
| A | CYS91 |
| A | ASP207 |
| A | HOH653 |
| site_id | AC7 |
| Number of Residues | 6 |
| Details | binding site for residue EDO A 507 |
| Chain | Residue |
| A | GLU317 |
| A | GLY318 |
| A | GLY320 |
| B | GLU177 |
| B | LYS178 |
| B | HOH963 |
| site_id | AC8 |
| Number of Residues | 7 |
| Details | binding site for residue EDO B 801 |
| Chain | Residue |
| A | GLU177 |
| A | LYS178 |
| A | LEU181 |
| B | GLU317 |
| B | GLY318 |
| B | GLY320 |
| B | HOH904 |
| site_id | AC9 |
| Number of Residues | 13 |
| Details | binding site for residue C2R B 802 |
| Chain | Residue |
| B | GLY273 |
| B | SER274 |
| B | ASP277 |
| B | SER301 |
| B | ALA302 |
| B | HIS303 |
| B | LYS304 |
| B | ALA329 |
| B | GLY330 |
| B | SER332 |
| B | GLY334 |
| B | LEU335 |
| B | SER370 |
| site_id | AD1 |
| Number of Residues | 13 |
| Details | binding site for residue C2R B 803 |
| Chain | Residue |
| B | GLU97 |
| B | ARG101 |
| B | GLY106 |
| B | SER107 |
| B | ASP189 |
| B | MET190 |
| B | LYS191 |
| B | ASP212 |
| B | TRP214 |
| B | ARG215 |
| B | ARG232 |
| B | IMD804 |
| B | HOH932 |
| site_id | AD2 |
| Number of Residues | 5 |
| Details | binding site for residue IMD B 804 |
| Chain | Residue |
| B | GLU97 |
| B | PHE129 |
| B | C2R803 |
| B | HOH947 |
| B | HOH1101 |
| site_id | AD3 |
| Number of Residues | 5 |
| Details | binding site for residue EDO B 805 |
| Chain | Residue |
| B | ILE411 |
| B | HOH903 |
| B | ILE73 |
| B | LYS74 |
| B | ILE203 |
| site_id | AD4 |
| Number of Residues | 4 |
| Details | binding site for residue EDO B 806 |
| Chain | Residue |
| A | TYR122 |
| B | GLU315 |
| B | ASP319 |
| B | HOH920 |
| site_id | AD5 |
| Number of Residues | 6 |
| Details | binding site for residue EDO B 807 |
| Chain | Residue |
| B | PRO89 |
| B | GLN90 |
| B | CYS91 |
| B | ASP207 |
| B | HOH976 |
| B | HOH999 |
| site_id | AD6 |
| Number of Residues | 4 |
| Details | binding site for residue EDO B 808 |
| Chain | Residue |
| B | SER262 |
| B | GLY292 |
| B | HOH983 |
| B | HOH989 |
| site_id | AD7 |
| Number of Residues | 2 |
| Details | binding site for residue EDO B 809 |
| Chain | Residue |
| B | TYR119 |
| B | LYS120 |
Functional Information from PROSITE/UniProt
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:17224163, ECO:0007744|PDB:2H31 |
| Chain | Residue | Details |
| A | SER332 | |
| B | SER332 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | MOD_RES: N-acetylalanine => ECO:0000269|Ref.6, ECO:0007744|PubMed:19413330, ECO:0007744|PubMed:22223895 |
| Chain | Residue | Details |
| A | ALA2 | |
| B | ALA2 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphotyrosine => ECO:0000250|UniProtKB:Q9DCL9 |
| Chain | Residue | Details |
| A | TYR22 | |
| B | TYR22 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:16964243, ECO:0007744|PubMed:17924679, ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:18691976, ECO:0007744|PubMed:19369195, ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:23186163 |
| Chain | Residue | Details |
| A | SER27 | |
| B | SER27 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | MOD_RES: N6-acetyllysine => ECO:0000250|UniProtKB:Q9DCL9 |
| Chain | Residue | Details |
| A | LYS36 | |
| B | LYS36 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:23186163 |
| Chain | Residue | Details |
| A | SER107 | |
| B | SER107 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphothreonine => ECO:0007744|PubMed:18691976, ECO:0007744|PubMed:23186163 |
| Chain | Residue | Details |
| A | THR238 | |
| B | THR238 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 2 |
| Details | MOD_RES: N6-acetyllysine => ECO:0007744|PubMed:19608861 |
| Chain | Residue | Details |
| A | LYS247 | |
| B | LYS247 |
| site_id | SWS_FT_FI9 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163, ECO:0007744|PubMed:24275569 |
| Chain | Residue | Details |
| A | SER274 | |
| B | SER274 |
