Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

6YB8

Human octameric PAICS in complex with CAIR and SAICAR

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0003824	molecular_function	catalytic activity
A	0004638	molecular_function	phosphoribosylaminoimidazole carboxylase activity
A	0004639	molecular_function	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
A	0005515	molecular_function	protein binding
A	0005524	molecular_function	ATP binding
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0006164	biological_process	purine nucleotide biosynthetic process
A	0006177	biological_process	GMP biosynthetic process
A	0006189	biological_process	'de novo' IMP biosynthetic process
A	0009113	biological_process	purine nucleobase biosynthetic process
A	0016020	cellular_component	membrane
A	0016829	molecular_function	lyase activity
A	0016831	molecular_function	carboxy-lyase activity
A	0016874	molecular_function	ligase activity
A	0042802	molecular_function	identical protein binding
A	0044208	biological_process	'de novo' AMP biosynthetic process
A	0045296	molecular_function	cadherin binding
A	0070062	cellular_component	extracellular exosome
A	0097294	biological_process	'de novo' XMP biosynthetic process
B	0000166	molecular_function	nucleotide binding
B	0003824	molecular_function	catalytic activity
B	0004638	molecular_function	phosphoribosylaminoimidazole carboxylase activity
B	0004639	molecular_function	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
B	0005515	molecular_function	protein binding
B	0005524	molecular_function	ATP binding
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0006164	biological_process	purine nucleotide biosynthetic process
B	0006177	biological_process	GMP biosynthetic process
B	0006189	biological_process	'de novo' IMP biosynthetic process
B	0009113	biological_process	purine nucleobase biosynthetic process
B	0016020	cellular_component	membrane
B	0016829	molecular_function	lyase activity
B	0016831	molecular_function	carboxy-lyase activity
B	0016874	molecular_function	ligase activity
B	0042802	molecular_function	identical protein binding
B	0044208	biological_process	'de novo' AMP biosynthetic process
B	0045296	molecular_function	cadherin binding
B	0070062	cellular_component	extracellular exosome
B	0097294	biological_process	'de novo' XMP biosynthetic process

Functional Information from PDB Data

site_id	AC1
Number of Residues	14
Details	binding site for residue C2R A 501

Chain	Residue
A	SER274
A	GLY334
A	LEU335
A	PRO369
A	SER370
A	HOH649
A	ASP277
A	SER301
A	ALA302
A	HIS303
A	LYS304
A	ALA329
A	GLY330
A	SER332

site_id	AC2
Number of Residues	21
Details	binding site for residue OK8 A 502

Chain	Residue
A	LYS17
A	ALA41
A	GLY42
A	ASN43
A	ARG101
A	GLY106
A	SER107
A	ASP137
A	ASP189
A	MET190
A	LYS191
A	ASP212
A	TRP214
A	ARG215
A	LYS228
A	ARG232
A	IMD503
A	HOH681
A	HOH685
A	HOH689
A	HOH696

site_id	AC3
Number of Residues	4
Details	binding site for residue IMD A 503

Chain	Residue
A	GLU97
A	PHE129
A	OK8502
A	HOH784

site_id	AC4
Number of Residues	4
Details	binding site for residue EDO A 504

Chain	Residue
A	LYS74
A	ILE203
A	ILE411
A	HOH675

site_id	AC5
Number of Residues	4
Details	binding site for residue EDO A 505

Chain	Residue
A	GLU315
A	ASP319
A	HOH752
B	TYR122

site_id	AC6
Number of Residues	5
Details	binding site for residue EDO A 506

Chain	Residue
A	PRO89
A	GLN90
A	CYS91
A	ASP207
A	HOH653

site_id	AC7
Number of Residues	6
Details	binding site for residue EDO A 507

Chain	Residue
A	GLU317
A	GLY318
A	GLY320
B	GLU177
B	LYS178
B	HOH963

site_id	AC8
Number of Residues	7
Details	binding site for residue EDO B 801

Chain	Residue
A	GLU177
A	LYS178
A	LEU181
B	GLU317
B	GLY318
B	GLY320
B	HOH904

site_id	AC9
Number of Residues	13
Details	binding site for residue C2R B 802

Chain	Residue
B	GLY273
B	SER274
B	ASP277
B	SER301
B	ALA302
B	HIS303
B	LYS304
B	ALA329
B	GLY330
B	SER332
B	GLY334
B	LEU335
B	SER370

site_id	AD1
Number of Residues	13
Details	binding site for residue C2R B 803

Chain	Residue
B	GLU97
B	ARG101
B	GLY106
B	SER107
B	ASP189
B	MET190
B	LYS191
B	ASP212
B	TRP214
B	ARG215
B	ARG232
B	IMD804
B	HOH932

site_id	AD2
Number of Residues	5
Details	binding site for residue IMD B 804

Chain	Residue
B	GLU97
B	PHE129
B	C2R803
B	HOH947
B	HOH1101

site_id	AD3
Number of Residues	5
Details	binding site for residue EDO B 805

Chain	Residue
B	ILE411
B	HOH903
B	ILE73
B	LYS74
B	ILE203

site_id	AD4
Number of Residues	4
Details	binding site for residue EDO B 806

Chain	Residue
A	TYR122
B	GLU315
B	ASP319
B	HOH920

site_id	AD5
Number of Residues	6
Details	binding site for residue EDO B 807

Chain	Residue
B	PRO89
B	GLN90
B	CYS91
B	ASP207
B	HOH976
B	HOH999

site_id	AD6
Number of Residues	4
Details	binding site for residue EDO B 808

Chain	Residue
B	SER262
B	GLY292
B	HOH983
B	HOH989

site_id	AD7
Number of Residues	2
Details	binding site for residue EDO B 809

Chain	Residue
B	TYR119
B	LYS120

Functional Information from PROSITE/UniProt

site_id	PS01057
Number of Residues	15
Details	SAICAR_SYNTHETASE_1 SAICAR synthetase signature 1. MIPIEwVCRriaTGS

Chain	Residue	Details
A	MET93-SER107

site_id	PS01058
Number of Residues	9
Details	SAICAR_SYNTHETASE_2 SAICAR synthetase signature 2. LVDmKIEFG

Chain	Residue	Details
A	LEU187-GLY195

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	10
Details	Region: {"description":"Linker","evidences":[{"source":"PubMed","id":"17224163","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"2H31","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	316
Details	Region: {"description":"AIR carboxylase domain","evidences":[{"source":"PubMed","id":"17224163","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2H31","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"17224163","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2H31","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	2
Details	Modified residue: {"description":"Phosphotyrosine","evidences":[{"source":"UniProtKB","id":"Q9DCL9","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI5
Number of Residues	2
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"16964243","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"17924679","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"18669648","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"18691976","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"19369195","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"19690332","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"20068231","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"21406692","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI6
Number of Residues	2
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"UniProtKB","id":"Q9DCL9","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI7
Number of Residues	2
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"18669648","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI8
Number of Residues	2
Details	Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"18691976","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI9
Number of Residues	2
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"19608861","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI10
Number of Residues	2
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"24275569","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)