6YB8

Human octameric PAICS in complex with CAIR and SAICAR

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	Multifunctional protein ADE2	polymer	425	47135.1	2	UniProt (P22234) Pfam (PF01259) Pfam (PF00731)	Homo sapiens (Human)
2	C, K, L (A, B)	5-AMINO-1-(5-O-PHOSPHONO-BETA-D-RIBOFURANOSYL)-1H-IMIDAZOLE-4-CARBOXYLIC ACID	non-polymer		339.2	3	Chemie (C2R)
3	D (A)	(2~{S})-2-[[5-azanyl-1-[(2~{R},3~{R},4~{S},5~{R})-3,4-bis(oxidanyl)-5-(phosphonooxymethyl)oxolan-2-yl]imidazol-4-yl]car bonylamino]butanedioic acid	non-polymer		454.3	1	Chemie (OK8)
4	E, M (A, B)	IMIDAZOLE	non-polymer		69.1	2	Chemie (IMD)
5	F, G, H, I, J... (A, B)	1,2-ETHANEDIOL	non-polymer		62.1	10	Chemie (EDO)
6	S, T (A, B)	water	water		18.0	452	Chemie (HOH)

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	94270.2
Non-Polymers*	Number of molecules	16
	Total formula weight	2230.7
All*	Total formula weight	96500.9

*Water molecules are not included.