4YLW

Crystal structure of human dihydroorotate dehydrogenase (DHODH) with No.33 compound

Summary for 4YLW

• Entry DOI: 10.2210/pdb4ylw/pdb
• Related: 4LS0
• Descriptor: Dihydroorotate dehydrogenase (quinone), mitochondrial, methyl (2Z)-cyano[3-(3-fluoro-4'-methoxybiphenyl-4-yl)-4-oxo-1,3-thiazolidin-2-ylidene]acetate, FLAVIN MONONUCLEOTIDE, ... (6 entities in total)
• Functional Keywords: inhibitor, rheumatoid arthritis, complex, oxidoreductase-oxidoreductase inhibitor complex, oxidoreductase/oxidoreductase inhibitor
• Biological source: Homo sapiens (Human)
• Cellular location: Mitochondrion inner membrane ; Single-pass membrane protein : Q02127
• Total number of polymer chains: 1
• Total formula weight: 44607.89

Authors

Wu, D.,Ouyang, P.,Lu, W.,Huang, J. (deposition date: 2015-03-06, release date: 2016-03-09, Last modification date: 2023-11-08)

• Primary citation: Wu, D.,Ouyang, P.,Lu, W.,Huang, J.; Crystal structure of human dihydroorotate dehydrogenase (DHODH) with No.33 compound; To Be Published,

Experimental method

X-RAY DIFFRACTION (1.79 Å)