PDB: 5434 件ウェブページステータス検索Chemie searchBIRD

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3QQ7	Crystal Structure of the p97 N-terminal domain 分子名称: CHLORIDE ION, COBALT (II) ION, GLYCEROL, ... 著者 Haenzelmann, P, Schindelin, H. 登録日 2011-02-15 公開日 2011-06-22 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (2.65 Å) 主引用文献 Hierarchical Binding of Cofactors to the AAA ATPase p97. Structure, 19, 2011
1MP1	Solution structure of the PWI motif from SRm160 分子名称: Ser/Arg-related nuclear matrix protein 著者 Szymczyna, B.R, Bowman, J, McCracken, S, Pineda-Lucena, A, Lu, Y, Cox, B, Lambermon, M, Graveley, B.R, Arrowsmith, C.H, Blencowe, B.J. 登録日 2002-09-11 公開日 2003-09-16 最終更新日 2024-05-22 実験手法 SOLUTION NMR 主引用文献 Structure and function of the PWI motif: a novel nucleic acid-binding domain that facilitates pre-mRNA processing. Genes Dev., 17, 2003
3QBN	Structure of Human Aurora A in Complex with a diaminopyrimidine 分子名称: 5-chloro-N~4~-cyclopropyl-N~2~-[4-(2-methoxyethoxy)phenyl]pyrimidine-2,4-diamine, Serine/threonine-protein kinase 6 著者 Gruetter, C, Simard, J.R, Rauh, D. 登録日 2011-01-13 公開日 2012-01-18 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (3.5 Å) 主引用文献 Identification of Ustilago maydis Aurora kinase as a novel antifungal target. Acs Chem.Biol., 6, 2011
3Q6S	The crystal structure of the heterochromatin protein 1 beta chromoshadow domain complexed with a peptide from Shugoshin 1 分子名称: Chromobox protein homolog 1, Shugoshin-like 1 著者 Brautigam, C.A, Chaudhary, J, Yu, H. 登録日 2011-01-03 公開日 2011-12-14 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (1.93 Å) 主引用文献 Mitotic centromeric targeting of HP1 and its binding to Sgo1 are dispensable for sister-chromatid cohesion in human cells. Mol Biol Cell, 22, 2011
1MKJ	Human Kinesin Motor Domain With Docked Neck Linker 分子名称: ADENOSINE-5'-DIPHOSPHATE, KINESIN HEAVY CHAIN, MAGNESIUM ION, ... 著者 Sindelar, C.V, Budny, M.J, Rice, S, Naber, N, Fletterick, R, Cooke, R. 登録日 2002-08-29 公開日 2002-10-30 最終更新日 2024-02-14 実験手法 X-RAY DIFFRACTION (2.7 Å) 主引用文献 Two conformations in the human kinesin power stroke defined by X-ray crystallography and EPR spectroscopy. Nat.Struct.Biol., 9, 2002
1M9X	X-ray crystal structure of Cyclophilin A/HIV-1 CA N-terminal domain (1-146) M-type H87A,A88M,G89A Complex. 分子名称: Cyclophilin A, HIV-1 Capsid 著者 Howard, B.R, Vajdos, F.F, Li, S, Sundquist, W.I, Hill, C.P. 登録日 2002-07-30 公開日 2003-05-27 最終更新日 2024-02-14 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 Structural insights into the catalytic mechanism of cyclophilin A Nat.Struct.Biol., 10, 2003
1M9Y	X-ray crystal structure of Cyclophilin A/HIV-1 CA N-terminal domain (1-146) M-type H87A,G89A Complex. 分子名称: Cyclophilin A, HIV-1 Capsid 著者 Howard, B.R, Vajdos, F.F, Li, S, Sundquist, W.I, Hill, C.P. 登録日 2002-07-30 公開日 2003-05-27 最終更新日 2024-02-14 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Structural insights into the catalytic mechanism of cyclophilin A Nat.Struct.Biol., 10, 2003
1MQ4	Crystal Structure of Aurora-A Protein Kinase 分子名称: ADENOSINE-5'-DIPHOSPHATE, AURORA-RELATED KINASE 1, MAGNESIUM ION, ... 著者 Nowakowski, J, Cronin, C.N, McRee, D.E, Knuth, M.W, Nelson, C, Pavletich, N.P, Rodgers, J, Sang, B.-C, Scheibe, D.N, Swanson, R.V, Thompson, D.A. 登録日 2002-09-13 公開日 2003-09-16 最終更新日 2024-02-14 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Structures of the Cancer-Related Aurora-A, FAK and EphA2 Protein Kinases from Nanovolume Crystallography Structure, 10, 2002
1MCX	STRUCTURE OF FULL-LENGTH ANNEXIN A1 IN THE PRESENCE OF CALCIUM 分子名称: ANNEXIN I, CALCIUM ION 著者 Luecke, H, Rosengarth, A. 登録日 2002-08-06 公開日 2003-03-04 最終更新日 2021-10-27 実験手法 X-RAY DIFFRACTION (2.03 Å) 主引用文献 A Calcium-driven Conformational Switch of the N-terminaland Core Domains of Annexin A1 J.Mol.Biol., 326, 2003
1M9E	X-ray crystal structure of Cyclophilin A/HIV-1 CA N-terminal domain (1-146) M-type H87A Complex. 分子名称: Cyclophilin A, HIV-1 Capsid 著者 Howard, B.R, Vajdos, F.F, Li, S, Sundquist, W.I, Hill, C.P. 登録日 2002-07-28 公開日 2003-05-27 最終更新日 2024-02-14 実験手法 X-RAY DIFFRACTION (1.72 Å) 主引用文献 Structural insights into the catalytic mechanism of cyclophilin A Nat.Struct.Biol., 10, 2003
7EFA	Crystal structure of the complex between the C-terminal domain of mouse MUTYH and human PCNA 分子名称: Adenine DNA glycosylase, Proliferating cell nuclear antigen 著者 Nakamura, T, Nakabeppu, Y, Yamagata, Y. 登録日 2021-03-21 公開日 2021-06-23 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (2.7 Å) 主引用文献 Structure of the mammalian adenine DNA glycosylase MUTYH: insights into the base excision repair pathway and cancer. Nucleic Acids Res., 49, 2021
7E2E	Crystal structure of the Estrogen-Related Receptor alpha (ERRalpha) ligand-binding domain (LBD) in complex with an agonist DS45500853 and a PGC-1alpha peptide 分子名称: 1-[4-(3-tert-butyl-4-oxidanyl-phenoxy)phenyl]ethanone, IODIDE ION, Peroxisome proliferator-activated receptor gamma coactivator 1-alpha, ... 著者 Ito, S, Shinozuka, T, Kimura, T, Izumi, M, Wakabayashi, K. 登録日 2021-02-05 公開日 2021-06-30 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (2.7 Å) 主引用文献 Discovery of a Novel Class of ERR alpha Agonists. Acs Med.Chem.Lett., 12, 2021
7EHJ	human MTHFD2 in complex with compound 21, cofactor and phosphate. 分子名称: (2S)-2-[[4-[(4-azanyl-6-oxidanyl-pyrimidin-5-yl)carbamoylamino]phenyl]carbonylamino]pentanedioic acid, Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial, ... 著者 Lee, L.C, Peng, Y.H, Wu, S.Y. 登録日 2021-03-29 公開日 2021-08-11 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (2.16 Å) 主引用文献 Xanthine Derivatives Reveal an Allosteric Binding Site in Methylenetetrahydrofolate Dehydrogenase 2 (MTHFD2). J.Med.Chem., 64, 2021
7EHM	Human MTHFD2 in complex with compound 21 and 15 分子名称: (2S)-2-[[4-[(4-azanyl-6-oxidanyl-pyrimidin-5-yl)carbamoylamino]phenyl]carbonylamino]pentanedioic acid, (2S)-2-[[4-[[1-[(3,4-dichlorophenyl)methyl]-3,7-dimethyl-2,6-bis(oxidanylidene)purin-8-yl]amino]phenyl]carbonylamino]pentanedioic acid, Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, ... 著者 Lee, L.C, Peng, Y.H, Wu, S.Y. 登録日 2021-03-30 公開日 2021-08-11 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (2.13 Å) 主引用文献 Xanthine Derivatives Reveal an Allosteric Binding Site in Methylenetetrahydrofolate Dehydrogenase 2 (MTHFD2). J.Med.Chem., 64, 2021
7EHN	Human MTHFD2 in complex with compound 21 and 9 分子名称: (2S)-2-[[4-[(4-azanyl-6-oxidanyl-pyrimidin-5-yl)carbamoylamino]phenyl]carbonylamino]pentanedioic acid, 3-[4-[[1-[(4-chloranyl-1H-indol-2-yl)methyl]-3,7-dimethyl-2,6-bis(oxidanylidene)purin-8-yl]amino]-6-methyl-pyrimidin-2-yl]propanoic acid, Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, ... 著者 Lee, L.C, Peng, Y.H, Wu, S.Y. 登録日 2021-03-30 公開日 2021-08-11 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (2.25 Å) 主引用文献 Xanthine Derivatives Reveal an Allosteric Binding Site in Methylenetetrahydrofolate Dehydrogenase 2 (MTHFD2). J.Med.Chem., 64, 2021
7EHV	Human MTHFD2 in complex with compound 21 and 3 分子名称: (2S)-2-[[4-[(4-azanyl-6-oxidanyl-pyrimidin-5-yl)carbamoylamino]phenyl]carbonylamino]pentanedioic acid, 1-(3,4-dichlorobenzyl)-8-(((1R,4R)-4-hydroxycyclohexyl)amino)-3,7-dimethyl-3,7-dihydro-1H-purine-2,6-dione, Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, ... 著者 Lee, L.C, Peng, Y.H, Wu, S.Y. 登録日 2021-03-30 公開日 2021-08-11 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (2.61 Å) 主引用文献 Xanthine Derivatives Reveal an Allosteric Binding Site in Methylenetetrahydrofolate Dehydrogenase 2 (MTHFD2). J.Med.Chem., 64, 2021
7E4W	Human Transcriptional Co-activator PC4 (C-terminal Domain) in space group P1211 分子名称: Activated RNA polymerase II transcriptional coactivator p15 著者 Dev, A, Pandey, B, Basu, G. 登録日 2021-02-15 公開日 2021-09-22 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (2.9 Å) 主引用文献 Insights on the disruption of the complex between human positive coactivator 4 and p53 by small molecules. Biochem.Biophys.Res.Commun., 578, 2021
7DTG	Crystal structure of lamin B1 Ig-like domain from human 分子名称: Lamin-B1 著者 Ahn, J, Lee, J, Ha, N.-C. 登録日 2021-01-05 公開日 2021-11-03 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (3.6 Å) 主引用文献 Beta-strand-mediated dimeric formation of the Ig-like domains of human lamin A/C and B1. Biochem.Biophys.Res.Commun., 550, 2021
7EHW	BRD4-BD1 in complex with LT-642-602 分子名称: 1-[4-ethyl-2-methyl-5-(6-morpholin-4-yl-1H-benzimidazol-2-yl)-1H-pyrrol-3-yl]ethanone, Bromodomain-containing protein 4 著者 Zheng, W, Kong, B, Tang, W, Zhu, J, Chen, Y. 登録日 2021-03-30 公開日 2022-03-30 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (1.65 Å) 主引用文献 BRD4-BD1 in complex with LT-642-602 To Be Published
7EHY	BRD4-BD1 in complex with LT-448-138 分子名称: 1-[2,4-dimethyl-5-[5-(4-methylpiperazin-1-yl)-1H-benzimidazol-2-yl]-1H-pyrrol-3-yl]ethanone, Bromodomain-containing protein 4 著者 Zheng, W, Kong, B, Tang, W, Zhu, J, Chen, Y. 登録日 2021-03-30 公開日 2022-03-30 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (1.51 Å) 主引用文献 BRD4-BD1 in complex with LT-642-602 To Be Published
7EIG	BRD4-BD1 in complex with LT-730-903 分子名称: 1-[5-(5-azanyl-1H-benzimidazol-2-yl)-2-methyl-4-phenyl-1H-pyrrol-3-yl]ethanone, Bromodomain-containing protein 4 著者 Zheng, W, Kong, B, Tang, W, Zhu, J, Chen, Y. 登録日 2021-03-31 公開日 2022-04-06 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (1.3 Å) 主引用文献 BRD4-BD1 in complex with LT-730-903 To Be Published
7EIC	Crystal structure of AF9 YEATS domain in complex with H4K5acK8ac peptide 分子名称: DI(HYDROXYETHYL)ETHER, GLYCEROL, Histone H4, ... 著者 Kikuchi, M, Umehara, T. 登録日 2021-03-30 公開日 2022-04-06 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (1.95 Å) 主引用文献 Elucidation of binding preferences of YEATS domains to site-specific acetylated nucleosome core particles. J.Biol.Chem., 298, 2022
7EID	Crystal structure of AF9 YEATS domain in complex with H4K8acK12ac peptide 分子名称: GLYCEROL, Histone H4, Protein AF-9 著者 Kikuchi, M, Umehara, T. 登録日 2021-03-30 公開日 2022-04-06 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Elucidation of binding preferences of YEATS domains to site-specific acetylated nucleosome core particles. J.Biol.Chem., 298, 2022
7EIK	RD4-BD1 in complex with LT-872-297 分子名称: 1-[2-methyl-5-[6-(4-methylpiperazin-1-yl)-1H-benzimidazol-2-yl]-4-(1-methylpyrazol-4-yl)-1H-pyrrol-3-yl]ethanone, Bromodomain-containing protein 4 著者 Zheng, W, Kong, B, Tang, W, Zhu, J, Chen, Y. 登録日 2021-03-31 公開日 2022-04-06 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 RD4-BD1 in complex with LT-872-297 To Be Published
7EIL	BRD4-BD1 in complex with LT-909-110 分子名称: Bromodomain-containing protein 4, N-[4-[4-ethanoyl-5-methyl-2-[6-(4-methylpiperazin-1-yl)-1H-benzimidazol-2-yl]-1H-pyrrol-3-yl]phenyl]ethanamide 著者 Zheng, W, Kong, B, Tang, W, Zhu, J, Chen, Y. 登録日 2021-03-31 公開日 2022-04-06 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 Discovery of 1-(5-(1H-benzo[d]imidazole-2-yl)-2,4-dimethyl-1H-pyrrol-3-yl)ethan-1-one derivatives as novel and potent bromodomain and extra-terminal (BET) inhibitors with anticancer efficacy Eur.J.Med.Chem., 227, 2022

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