7EHN
Human MTHFD2 in complex with compound 21 and 9
Summary for 7EHN
Entry DOI | 10.2210/pdb7ehn/pdb |
Related | 7EHJ 7EHM |
Descriptor | Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial, 3-[4-[[1-[(4-chloranyl-1H-indol-2-yl)methyl]-3,7-dimethyl-2,6-bis(oxidanylidene)purin-8-yl]amino]-6-methyl-pyrimidin-2-yl]propanoic acid, (2S)-2-[[4-[(4-azanyl-6-oxidanyl-pyrimidin-5-yl)carbamoylamino]phenyl]carbonylamino]pentanedioic acid, ... (4 entities in total) |
Functional Keywords | mthfd2, methylenetetrahydrofolate dehydrogenase 2, 1c metabolism, mitocondria, oxidoreductase |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 2 |
Total formula weight | 70249.72 |
Authors | Lee, L.C.,Peng, Y.H.,Wu, S.Y. (deposition date: 2021-03-30, release date: 2021-08-11, Last modification date: 2023-11-29) |
Primary citation | Lee, L.C.,Peng, Y.H.,Chang, H.H.,Hsu, T.,Lu, C.T.,Huang, C.H.,Hsueh, C.C.,Kung, F.C.,Kuo, C.C.,Jiaang, W.T.,Wu, S.Y. Xanthine Derivatives Reveal an Allosteric Binding Site in Methylenetetrahydrofolate Dehydrogenase 2 (MTHFD2). J.Med.Chem., 64:11288-11301, 2021 Cited by PubMed: 34337952DOI: 10.1021/acs.jmedchem.1c00663 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.25 Å) |
Structure validation
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