3QBN

Structure of Human Aurora A in Complex with a diaminopyrimidine

Summary for 3QBN

Entry DOI	10.2210/pdb3qbn/pdb
Descriptor	Serine/threonine-protein kinase 6, 5-chloro-N~4~-cyclopropyl-N~2~-[4-(2-methoxyethoxy)phenyl]pyrimidine-2,4-diamine (2 entities in total)
Functional Keywords	kinase domain, diaminopyrimidine, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological source	Homo sapiens (human)
Cellular location	Cytoplasm, cytoskeleton, centrosome: O14965
Total number of polymer chains	1
Total formula weight	32837.01
Authors	Gruetter, C.,Simard, J.R.,Rauh, D. (deposition date: 2011-01-13, release date: 2012-01-18, Last modification date: 2023-09-13)
Primary citation	Tueckmantel, S.,Greul, J.N.,Janning, P.,Brockmeyer, A.,Gruetter, C.,Simard, J.R.,Gutbrod, O.,Beck, M.E.,Tietjen, K.,Rauh, D.,Schreier, P.H. Identification of Ustilago maydis Aurora kinase as a novel antifungal target. Acs Chem.Biol., 6:926-933, 2011 Cited by PubMed: 21671622 DOI: 10.1021/cb200112y PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3.5 Å)

Structure validation