3QBN
Structure of Human Aurora A in Complex with a diaminopyrimidine
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | Serine/threonine-protein kinase 6 | polymer | 281 | 32502.2 | 1 | UniProt (O14965) Pfam (PF00069) In PDB | Homo sapiens (human) | Aurora kinase A, Aurora/IPL1-related kinase 1, ARK-1, Aurora-related kinase 1, hARK1, Breast tumor-amplified kinase, Serine/threonine-protein kinase 15, Serine/threonine-protein kinase aurora-A |
| 2 | A | 5-chloro-N~4~-cyclopropyl-N~2~-[4-(2-methoxyethoxy)phenyl]pyrimidine-2,4-diamine | non-polymer | 334.8 | 1 | Chemie (E9Z) |
Sequence modifications
A: 124 - 403 (UniProt: O14965)
| PDB | External Database | Details |
|---|---|---|
| Gly 123 | - | expression tag |
| Cys 279 | Val 279 | engineered mutation |
| Ser 290 | Cys 290 | engineered mutation |
| Ser 393 | Cys 393 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 32502.2 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 334.8 | |
| All* | Total formula weight | 32837.0 |
