7EHJ

human MTHFD2 in complex with compound 21, cofactor and phosphate.

Summary for 7EHJ

Entry DOI	10.2210/pdb7ehj/pdb
Related	7EHM 7EHN 7EHV
Descriptor	Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial, (2S)-2-[[4-[(4-azanyl-6-oxidanyl-pyrimidin-5-yl)carbamoylamino]phenyl]carbonylamino]pentanedioic acid, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, ... (5 entities in total)
Functional Keywords	mthfd2, methylenetetrahydrofolate dehydrogenase 2, 1c metabolism, mitocondria, oxidoreductase
Biological source	Homo sapiens (Human)
Total number of polymer chains	2
Total formula weight	70720.62
Authors	Lee, L.C.,Peng, Y.H.,Wu, S.Y. (deposition date: 2021-03-29, release date: 2021-08-11, Last modification date: 2023-11-29)
Primary citation	Lee, L.C.,Peng, Y.H.,Chang, H.H.,Hsu, T.,Lu, C.T.,Huang, C.H.,Hsueh, C.C.,Kung, F.C.,Kuo, C.C.,Jiaang, W.T.,Wu, S.Y. Xanthine Derivatives Reveal an Allosteric Binding Site in Methylenetetrahydrofolate Dehydrogenase 2 (MTHFD2). J.Med.Chem., 64:11288-11301, 2021 Cited by PubMed: 34337952 DOI: 10.1021/acs.jmedchem.1c00663 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.16 Å)

Structure validation