6I3Z
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6i3z by Molmil](/molmil-images/mine/6i3z) | Fab fragment of an antibody selective for wild-type alpha-1-antitrypsin in complex with its antigen | 分子名称: | Alpha-1-antitrypsin, Fab 2H2 heavy chain, Fab 2H2 light chain, ... | 著者 | Laffranchi, M, Elliston, E.L.K, Miranda, E, Perez, J, Jagger, A.M, Fra, A, Lomas, D.A, Irving, J.A. | 登録日 | 2018-11-08 | 公開日 | 2019-11-20 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (3.1 Å) | 主引用文献 | Intrahepatic heteropolymerization of M and Z alpha-1-antitrypsin. JCI Insight, 5, 2020
|
|
3DRM
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 3drm by Molmil](/molmil-images/mine/3drm) | 2.2 Angstrom Crystal Structure of Thr114Phe Alpha1-Antitrypsin | 分子名称: | Alpha-1-antitrypsin | 著者 | Gooptu, B, Nobeli, I, Purkiss, A, Phillips, R.L, Mallya, M, Lomas, D.A, Barrett, T.E. | 登録日 | 2008-07-11 | 公開日 | 2009-03-31 | 最終更新日 | 2023-08-30 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Crystallographic and cellular characterisation of two mechanisms stabilising the native fold of alpha1-antitrypsin: implications for disease and drug design. J.Mol.Biol., 387, 2009
|
|
3CWM
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 3cwm by Molmil](/molmil-images/mine/3cwm) | Crystal structure of alpha-1-antitrypsin complexed with citrate | 分子名称: | Alpha-1-antitrypsin, CITRIC ACID | 著者 | Morton, C.J, Hansen, G, Feil, S.C, Adams, J.J, Parker, M.W. | 登録日 | 2008-04-22 | 公開日 | 2008-09-23 | 最終更新日 | 2017-10-25 | 実験手法 | X-RAY DIFFRACTION (2.51 Å) | 主引用文献 | Preventing serpin aggregation: The molecular mechanism of citrate action upon antitrypsin unfolding. Protein Sci., 17, 2008
|
|
3CWL
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 3cwl by Molmil](/molmil-images/mine/3cwl) | Crystal structure of alpha-1-antitrypsin, crystal form B | 分子名称: | Alpha-1-antitrypsin, CHLORIDE ION | 著者 | Morton, C.J, Hansen, G, Feil, S.C, Adams, J.J, Parker, M.W. | 登録日 | 2008-04-22 | 公開日 | 2008-09-23 | 最終更新日 | 2017-10-25 | 実験手法 | X-RAY DIFFRACTION (2.44 Å) | 主引用文献 | Preventing serpin aggregation: The molecular mechanism of citrate action upon antitrypsin unfolding. Protein Sci., 17, 2008
|
|
3NE4
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 3ne4 by Molmil](/molmil-images/mine/3ne4) | |
3CAA
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 3caa by Molmil](/molmil-images/mine/3caa) | CLEAVED ANTICHYMOTRYPSIN A347R | 分子名称: | ANTICHYMOTRYPSIN | 著者 | Lukacs, C.M, Christianson, D.W. | 登録日 | 1997-08-18 | 公開日 | 1998-02-25 | 最終更新日 | 2024-05-22 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | Engineering an anion-binding cavity in antichymotrypsin modulates the "spring-loaded" serpin-protease interaction. Biochemistry, 37, 1998
|
|
2QUG
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 2qug by Molmil](/molmil-images/mine/2qug) | Crystal structure of alpha-1-antitrypsin, crystal form A | 分子名称: | Alpha-1-antitrypsin | 著者 | Hansen, G, Morton, C.J, Pearce, M.C, Feil, S.C, Adams, J.J, Parker, M.W, Bottomley, S.P. | 登録日 | 2007-08-05 | 公開日 | 2008-08-12 | 最終更新日 | 2011-07-13 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Preventing serpin aggregation: The molecular mechanism of citrate action upon antitrypsin unfolding. Protein Sci., 17, 2008
|
|
1CCV
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 1ccv by Molmil](/molmil-images/mine/1ccv) | |
1QLP
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 1qlp by Molmil](/molmil-images/mine/1qlp) | 2.0 ANGSTROM STRUCTURE OF INTACT ALPHA-1-ANTITRYPSIN: A CANONICAL TEMPLATE FOR ACTIVE SERPINS | 分子名称: | ALPHA-1-ANTITRYPSIN | 著者 | Elliott, P.R, Pei, X.Y, Dafforn, T, Read, R.J, Carrell, R.W, Lomas, D.A. | 登録日 | 1999-09-10 | 公開日 | 1999-09-27 | 最終更新日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Topography of a 2.0 A structure of alpha1-antitrypsin reveals targets for rational drug design to prevent conformational disease. Protein Sci., 9, 2000
|
|
1COA
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 1coa by Molmil](/molmil-images/mine/1coa) | THE EFFECT OF CAVITY CREATING MUTATIONS IN THE HYDROPHOBIC CORE OF CHYMOTRYPSIN INHIBITOR 2 | 分子名称: | CHYMOTRYPSIN INHIBITOR 2 | 著者 | Jackson, S.E, Moracci, M, Elmasry, N, Johnson, C.M, Fersht, A.R. | 登録日 | 1993-05-14 | 公開日 | 1994-01-31 | 最終更新日 | 2024-02-07 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Effect of cavity-creating mutations in the hydrophobic core of chymotrypsin inhibitor 2. Biochemistry, 32, 1993
|
|
1HP7
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 1hp7 by Molmil](/molmil-images/mine/1hp7) | A 2.1 ANGSTROM STRUCTURE OF AN UNCLEAVED ALPHA-1-ANTITRYPSIN SHOWS VARIABILITY OF THE REACTIVE CENTER AND OTHER LOOPS | 分子名称: | ALPHA-1-ANTITRYPSIN, BETA-MERCAPTOETHANOL, ZINC ION | 著者 | Kim, S.-J, Woo, J.-R, Seo, E.J, Yu, M.-H, Ryu, S.-E. | 登録日 | 2000-12-12 | 公開日 | 2001-03-14 | 最終更新日 | 2021-11-10 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | A 2.1 A resolution structure of an uncleaved alpha(1)-antitrypsin shows variability of the reactive center and other loops. J.Mol.Biol., 306, 2001
|
|
1D5S
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 1d5s by Molmil](/molmil-images/mine/1d5s) | CRYSTAL STRUCTURE OF CLEAVED ANTITRYPSIN POLYMER | 分子名称: | P1-ARG ANTITRYPSIN | 著者 | Dunstone, M.A, Dai, W, Whisstock, J.C, Rossjohn, J, Pike, R.N, Feil, S.C, Le Bonneic, B.F, Parker, M.W, Bottomley, S.P. | 登録日 | 1999-10-11 | 公開日 | 2000-04-02 | 最終更新日 | 2024-02-07 | 実験手法 | X-RAY DIFFRACTION (3 Å) | 主引用文献 | Cleaved antitrypsin polymers at atomic resolution. Protein Sci., 9, 2000
|
|
6E5M
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6e5m by Molmil](/molmil-images/mine/6e5m) | Crystallographic structure of the cyclic nonapeptide derived from the BTCI inhibitor bound to beta-trypsin in space group P 32 2 1 | 分子名称: | 9MER-PEPTIDE, CALCIUM ION, Cationic trypsin, ... | 著者 | Fernandes, J.C, Valadares, N.F, Freitas, S.M, Barbosa, J.A.R.G. | 登録日 | 2018-07-20 | 公開日 | 2019-03-13 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (1.612 Å) | 主引用文献 | Crystallographic structure of a complex between trypsin and a nonapeptide derived from a Bowman-Birk inhibitor found in Vigna unguiculata seeds. Arch. Biochem. Biophys., 665, 2019
|
|
8PTI
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8pti by Molmil](/molmil-images/mine/8pti) | CRYSTAL STRUCTURE OF A Y35G MUTANT OF BOVINE PANCREATIC TRYPSIN INHIBITOR | 分子名称: | BOVINE PANCREATIC TRYPSIN INHIBITOR | 著者 | Housset, D, Kim, K.-S, Fuchs, J, Woodward, C, Wlodawer, A. | 登録日 | 1990-12-17 | 公開日 | 1991-04-15 | 最終更新日 | 2024-06-05 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Crystal structure of a Y35G mutant of bovine pancreatic trypsin inhibitor. J.Mol.Biol., 220, 1991
|
|
1KDQ
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 1kdq by Molmil](/molmil-images/mine/1kdq) | Crystal Structure Analysis of the Mutant S189D Rat Chymotrypsin | 分子名称: | CALCIUM ION, CHYMOTRYPSIN B, B CHAIN, ... | 著者 | Szabo, E, Bocskei, Z, Naray-Szabo, G, Graf, L, Venekei, I. | 登録日 | 2001-11-13 | 公開日 | 2003-06-10 | 最終更新日 | 2021-10-27 | 実験手法 | X-RAY DIFFRACTION (2.55 Å) | 主引用文献 | Three Dimensional Structures of S189D Chymotrypsin and D189S Trypsin Mutants: The Effect of Polarity at Site 189 on a Protease-specific Stabilization of
the Substrate-binding Site J.Mol.Biol., 331, 2003
|
|
1TX7
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 1tx7 by Molmil](/molmil-images/mine/1tx7) | Bovine Trypsin complexed with p-amidinophenylmethylphosphinic acid (AMPA) | 分子名称: | (4-CARBAMIMIDOYLPHENYL)-METHYL-PHOSPHINIC ACID, CALCIUM ION, Trypsinogen | 著者 | Cui, J, Marankan, F, Fu, W, Crich, D, Mesecar, A, Johnson, M.E. | 登録日 | 2004-07-02 | 公開日 | 2005-09-20 | 最終更新日 | 2018-04-04 | 実験手法 | X-RAY DIFFRACTION (1.75 Å) | 主引用文献 | An oxyanion-hole selective serine protease inhibitor in complex with trypsin. Bioorg.Med.Chem., 10, 2002
|
|
1TPS
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 1tps by Molmil](/molmil-images/mine/1tps) | |
6MRQ
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6mrq by Molmil](/molmil-images/mine/6mrq) | Structure of ToPI1 inhibitor from Tityus obscurus scorpion venom in complex with trypsin | 分子名称: | CALCIUM ION, Cationic trypsin, SULFATE ION, ... | 著者 | Fernandes, J.C, Mourao, C.B.F, Schwartz, E.F, Barbosa, J.A.R.G. | 登録日 | 2018-10-15 | 公開日 | 2020-07-01 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (1.288 Å) | 主引用文献 | Head-to-Tail Cyclization after Interaction with Trypsin: A Scorpion Venom Peptide that Resembles Plant Cyclotides. J.Med.Chem., 63, 2020
|
|
4TPI
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 4tpi by Molmil](/molmil-images/mine/4tpi) | THE REFINED 2.2-ANGSTROMS (0.22-NM) X-RAY CRYSTAL STRUCTURE OF THE TERNARY COMPLEX FORMED BY BOVINE TRYPSINOGEN, VALINE-VALINE AND THE ARG15 ANALOGUE OF BOVINE PANCREATIC TRYPSIN INHIBITOR | 分子名称: | BOVINE PANCREATIC TRYPSIN INHIBITOR, CALCIUM ION, SULFATE ION, ... | 著者 | Bode, W, Walter, J. | 登録日 | 1985-06-11 | 公開日 | 1985-11-08 | 最終更新日 | 2024-06-05 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | The refined 2.2-A (0.22-nm) X-ray crystal structure of the ternary complex formed by bovine trypsinogen, valine-valine and the Arg15 analogue of bovine pancreatic trypsin inhibitor Eur.J.Biochem., 144, 1984
|
|
6EAT
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6eat by Molmil](/molmil-images/mine/6eat) | Crystallographic structure of the cyclic nonapeptide derived from the BTCI inhibitor bound to beta-trypsin in space group P 21 21 21. | 分子名称: | 9MER-PEPTIDE, CALCIUM ION, Cationic trypsin, ... | 著者 | Fernandes, J.C, Valadares, N.F, Freitas, S.M, Barbosa, J.A.R.G. | 登録日 | 2018-08-03 | 公開日 | 2019-03-13 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (1.149 Å) | 主引用文献 | Crystallographic structure of a complex between trypsin and a nonapeptide derived from a Bowman-Birk inhibitor found in Vigna unguiculata seeds. Arch. Biochem. Biophys., 665, 2019
|
|
4U2W
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 4u2w by Molmil](/molmil-images/mine/4u2w) | Atomic resolution crystal structure of HV-BBI protease inhibitor from amphibian skin in complex with bovine trypsin | 分子名称: | 1,2-ETHANEDIOL, Bowman-Birk trypsin inhibitor, CALCIUM ION, ... | 著者 | Grudnik, P, Golik, P, Malicki, S, Debowski, D, Legowska, A, Rolka, K, Dubin, G. | 登録日 | 2014-07-18 | 公開日 | 2015-01-14 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (1 Å) | 主引用文献 | Atomic resolution crystal structure of HV-BBI protease inhibitor from amphibian skin in complex with bovine trypsin. Proteins, 83, 2015
|
|
7Z9F
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7z9f by Molmil](/molmil-images/mine/7z9f) | Human anionic trypsin after autoproteolysis at Arg122 | 分子名称: | CALCIUM ION, Trypsin-2 | 著者 | Nagel, F, Palm, G.J, Delcea, M, Lammers, M. | 登録日 | 2022-03-21 | 公開日 | 2022-06-29 | 最終更新日 | 2024-05-01 | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | 主引用文献 | Structural Basis of the Pancreatitis-Associated Autoproteolytic Failsafe Mechanism in Human Anionic Trypsin. J Inflamm Res, 15, 2022
|
|
6PTI
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6pti by Molmil](/molmil-images/mine/6pti) | |
5C67
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 5c67 by Molmil](/molmil-images/mine/5c67) | |
7QE9
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7qe9 by Molmil](/molmil-images/mine/7qe9) | Human cationic trypsin (TRY1) complexed with serine protease inhibitor Kazal type 1 N34S (SPINK1 N34S) | 分子名称: | SULFATE ION, Serine protease inhibitor Kazal-type 1, Trypsin-1 | 著者 | Nagel, F, Palm, G.J, Delcea, M, Lammers, M. | 登録日 | 2021-12-01 | 公開日 | 2022-03-30 | 最終更新日 | 2024-05-01 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Structural and Biophysical Insights into SPINK1 Bound to Human Cationic Trypsin. Int J Mol Sci, 23, 2022
|
|