1QLP

2.0 ANGSTROM STRUCTURE OF INTACT ALPHA-1-ANTITRYPSIN: A CANONICAL TEMPLATE FOR ACTIVE SERPINS

Replaces:  2PSI

Summary for 1QLP

• Entry DOI: 10.2210/pdb1qlp/pdb
• Related: 1ATU 1KCT 1PSI 2PSI 7API 8API 9API
• Descriptor: ALPHA-1-ANTITRYPSIN (2 entities in total)
• Functional Keywords: serine protease inhibitor, serpin, glycoprotein, polymorphism, emphysema, disease mutation, acute phase
• Biological source: HOMO SAPIENS (HUMAN)
• Total number of polymer chains: 1
• Total formula weight: 44380.44

Authors

Elliott, P.R.,Pei, X.Y.,Dafforn, T.,Read, R.J.,Carrell, R.W.,Lomas, D.A. (deposition date: 1999-09-10, release date: 1999-09-27, Last modification date: 2023-12-13)

• Primary citation: Elliott, P.R.,Pei, X.Y.,Dafforn, T.R.,Lomas, D.A.; Topography of a 2.0 A structure of alpha1-antitrypsin reveals targets for rational drug design to prevent conformational disease.; Protein Sci., 9:1274-1281, 2000; PubMed: 10933492; DOI: 10.1110/ps.9.7.1274

Experimental method

X-RAY DIFFRACTION (2 Å)