6MRQ

Structure of ToPI1 inhibitor from Tityus obscurus scorpion venom in complex with trypsin

Summary for 6MRQ

• Entry DOI: 10.2210/pdb6mrq/pdb
• Descriptor: Cationic trypsin, inhibitor from Tityus obscurus scorpion venom (TopI1), CALCIUM ION, ... (5 entities in total)
• Functional Keywords: inhibitor, complex, scorpion, venom, hydrolase, toxin, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• Biological source: Bos taurus (Bovine); More
• Total number of polymer chains: 2
• Total formula weight: 29001.05

Authors

Fernandes, J.C.,Mourao, C.B.F.,Schwartz, E.F.,Barbosa, J.A.R.G. (deposition date: 2018-10-15, release date: 2020-07-01, Last modification date: 2023-10-11)

• Primary citation: Mourao, C.B.F.,Brand, G.D.,Fernandes, J.P.C.,Prates, M.V.,Bloch Jr., C.,Barbosa, J.A.R.G.,Freitas, S.M.,Restano-Cassulini, R.,Possani, L.D.,Schwartz, E.F.; Head-to-Tail Cyclization after Interaction with Trypsin: A Scorpion Venom Peptide that Resembles Plant Cyclotides.; J.Med.Chem., 63:9500-9511, 2020; PubMed: 32787139; DOI: 10.1021/acs.jmedchem.0c00686

Experimental method

X-RAY DIFFRACTION (1.288 Å)