PDB: 658 件ウェブページステータス検索Chemie searchBIRD

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6WK8	Crystal structure of Gdx-Clo from Small Multidrug Resistance family of transporters in complex with phenylguanidinium 分子名称: 1-phenylguanidine, DECYL-BETA-D-MALTOPYRANOSIDE, Dodecyldimethylphosphine oxide, ... 著者 Kermani, A.A, Stockbridge, R.B. 登録日 2020-04-15 公開日 2020-10-28 最終更新日 2024-03-06 実験手法 X-RAY DIFFRACTION (2.53 Å) 主引用文献 The structural basis of promiscuity in small multidrug resistance transporters. Nat Commun, 11, 2020
6WK5	Crystal structure of Gdx-Clo from Small Multidrug Resistance family of transporters 分子名称: L10 monobody, Multidrug resistance protein, SMR family 著者 Kermani, A.A, Stockbridge, R.B. 登録日 2020-04-15 公開日 2020-10-28 最終更新日 2020-12-09 実験手法 X-RAY DIFFRACTION (3.5 Å) 主引用文献 The structural basis of promiscuity in small multidrug resistance transporters. Nat Commun, 11, 2020
6WK9	Crystal structure of Gdx-Clo from Small Multidrug Resistance family of transporters in complex with octylguanidinium 分子名称: DECYL-BETA-D-MALTOPYRANOSIDE, L10 monobody, Multidrug resistance protein, ... 著者 Kermani, A.A, Stockbridge, R.B. 登録日 2020-04-15 公開日 2020-10-28 最終更新日 2024-03-06 実験手法 X-RAY DIFFRACTION (2.32 Å) 主引用文献 The structural basis of promiscuity in small multidrug resistance transporters. Nat Commun, 11, 2020
7WLS	Crystal structure of the multidrug efflux transporter BpeB from Burkholderia pseudomallei 分子名称: Efflux pump membrane transporter, TETRAETHYLENE GLYCOL, UNDECYL-MALTOSIDE 著者 Kato, T, Hung, L.-W, Yamashita, E, Okada, U, Terwilliger, T.C, Murakami, S. 登録日 2022-01-13 公開日 2023-07-19 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (2.94 Å) 主引用文献 Crystal structures of multidrug efflux transporters from Burkholderia pseudomallei suggest details of transport mechanism. Proc.Natl.Acad.Sci.USA, 120, 2023
7WLV	Crystal Structure of the Multidrug effulx transporter BpeF from Burkholderia pseudomallei. 分子名称: DODECYL-BETA-D-MALTOSIDE, Efflux pump membrane transporter 著者 Kato, T, Hung, L.-W, Yamashita, E, Okada, U, Terwilliger, T.C, Murakami, S. 登録日 2022-01-13 公開日 2023-07-19 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (3 Å) 主引用文献 Crystal structures of multidrug efflux transporters from Burkholderia pseudomallei suggest details of transport mechanism. Proc.Natl.Acad.Sci.USA, 120, 2023
6UY0	Cryo-EM structure of wild-type bovine multidrug resistance protein 1 (MRP1) under active turnover conditions 分子名称: ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, CHOLESTEROL, ... 著者 Johnson, Z.L, Chen, J. 登録日 2019-11-09 公開日 2020-06-10 最終更新日 2024-03-06 実験手法 ELECTRON MICROSCOPY (3.23 Å) 主引用文献 Characterization of the kinetic cycle of an ABC transporter by single-molecule and cryo-EM analyses. Elife, 9, 2020
8T1P	Heterodimeric ABC transporter BmrCD in the occluded conformation bound to ADPVi: BmrCD_OC-ADPVi 分子名称: (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, ADENOSINE-5'-TRIPHOSPHATE, ADP ORTHOVANADATE, ... 著者 Tang, Q, Mchaourab, H.S. 登録日 2023-06-02 公開日 2023-11-15 最終更新日 2023-11-22 実験手法 ELECTRON MICROSCOPY (2.96 Å) 主引用文献 Asymmetric conformations and lipid interactions shape the ATP-coupled cycle of a heterodimeric ABC transporter. Nat Commun, 14, 2023
8SZC	Heterodimeric ABC transporter BmrCD in the inward-facing conformation bound to substrate and ATP: BmrCD_IF-1HT/ATP 分子名称: (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, 2'-(4-ETHOXYPHENYL)-5-(4-METHYL-1-PIPERAZINYL)-2,5'-BI-BENZIMIDAZOLE, ADENOSINE-5'-TRIPHOSPHATE, ... 著者 Tang, Q, Mchaourab, H. 登録日 2023-05-29 公開日 2023-11-15 最終更新日 2023-11-22 実験手法 ELECTRON MICROSCOPY (3.06 Å) 主引用文献 Asymmetric conformations and lipid interactions shape the ATP-coupled cycle of a heterodimeric ABC transporter. Nat Commun, 14, 2023
8T3K	Heterodimeric ABC transporter BmrCD in the inward-facing conformation bound to ATP: BmrCD_IF-ATP2 分子名称: (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, ADENOSINE-5'-TRIPHOSPHATE, Probable multidrug resistance ABC transporter ATP-binding/permease protein YheH, ... 著者 Tang, Q, Mchaourab, H. 登録日 2023-06-07 公開日 2023-11-29 実験手法 ELECTRON MICROSCOPY (3.33 Å) 主引用文献 Asymmetric conformations and lipid interactions shape the ATP-coupled cycle of a heterodimeric ABC transporter. Nat Commun, 14, 2023
8FMV	Heterodimeric ABC transporter BmrCD in the inward-facing conformation bound to substrate and ATP: BmrCD_IF-2HT/ATP 分子名称: (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, 2'-(4-ETHOXYPHENYL)-5-(4-METHYL-1-PIPERAZINYL)-2,5'-BI-BENZIMIDAZOLE, ADENOSINE-5'-TRIPHOSPHATE, ... 著者 Tang, Q, Mchaourab, H. 登録日 2022-12-24 公開日 2023-11-15 最終更新日 2023-11-22 実験手法 ELECTRON MICROSCOPY (3.34 Å) 主引用文献 Asymmetric conformations and lipid interactions shape the ATP-coupled cycle of a heterodimeric ABC transporter. Nat Commun, 14, 2023
8FHK	Heterodimeric ABC transporter BmrCD in the occluded conformation bound to ATP: BmrCD_OC-ATP 分子名称: (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ... 著者 Tang, Q, Mchaourab, H. 登録日 2022-12-14 公開日 2023-11-15 最終更新日 2023-11-22 実験手法 ELECTRON MICROSCOPY (2.9 Å) 主引用文献 Asymmetric conformations and lipid interactions shape the ATP-coupled cycle of a heterodimeric ABC transporter. Nat Commun, 14, 2023
6BHU	Cryo-EM structure of ATP-bound, outward-facing bovine multidrug resistance protein 1 (MRP1) 分子名称: ADENOSINE-5'-TRIPHOSPHATE, CHOLESTEROL, MAGNESIUM ION, ... 著者 Johnson, Z.L, Chen, J. 登録日 2017-10-31 公開日 2017-12-27 最終更新日 2024-03-13 実験手法 ELECTRON MICROSCOPY (3.14 Å) 主引用文献 ATP Binding Enables Substrate Release from Multidrug Resistance Protein 1. Cell, 172, 2018
8FPF	Heterodimeric ABC transporter BmrCD in the inward-facing conformation bound to ATP: BmrCD_IF-ATP 分子名称: (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, ADENOSINE-5'-TRIPHOSPHATE, Probable multidrug resistance ABC transporter ATP-binding/permease protein YheH, ... 著者 Qingyu, T, Hassane, M. 登録日 2023-01-04 公開日 2023-11-22 実験手法 ELECTRON MICROSCOPY (3.27 Å) 主引用文献 Asymmetric conformations and lipid interactions shape the ATP-coupled cycle of a heterodimeric ABC transporter Nat Commun, 14, 2023
2V50	The Missing Part of the Bacterial MexAB-OprM System: Structural determination of the Multidrug Exporter MexB 分子名称: DODECYL-BETA-D-MALTOSIDE, MULTIDRUG RESISTANCE PROTEIN MEXB 著者 Sennhauser, G, Bukowska, M.A, Gruetter, M.G. 登録日 2008-10-01 公開日 2009-05-19 最終更新日 2023-12-13 実験手法 X-RAY DIFFRACTION (3 Å) 主引用文献 Crystal Structure of the Multidrug Exporter Mexb from Pseudomonas Aeruginosa. J.Mol.Biol., 389, 2009
8DEW	Cryo-electron microscopy structure of Neisseria gonorrhoeae multidrug efflux pump MtrD with LL-37 complex 分子名称: Antibacterial peptide LL-37, Efflux pump membrane transporter, PHOSPHATIDYLETHANOLAMINE 著者 Lyu, M, Yu, E.W. 登録日 2022-06-21 公開日 2022-09-14 最終更新日 2024-06-12 実験手法 ELECTRON MICROSCOPY (2.89 Å) 主引用文献 Structural Basis of Peptide-Based Antimicrobial Inhibition of a Resistance-Nodulation-Cell Division Multidrug Efflux Pump. Microbiol Spectr, 10, 2022
8DEU	Cryo-electron microscopy structure of Neisseria gonorrhoeae multidrug efflux pump MtrD with CASP peptide complex 分子名称: CASP peptide, Efflux pump membrane transporter, PHOSPHATIDYLETHANOLAMINE 著者 Lyu, M, Yu, E.W. 登録日 2022-06-21 公開日 2022-09-14 最終更新日 2022-11-09 実験手法 ELECTRON MICROSCOPY (2.95 Å) 主引用文献 Structural Basis of Peptide-Based Antimicrobial Inhibition of a Resistance-Nodulation-Cell Division Multidrug Efflux Pump. Microbiol Spectr, 10, 2022
8DEV	Cryo-electron microscopy structure of Neisseria gonorrhoeae multidrug efflux pump MtrD with colistin complex 分子名称: Colistin, Efflux pump membrane transporter, PHOSPHATIDYLETHANOLAMINE 著者 Lyu, M, Yu, E.W. 登録日 2022-06-21 公開日 2022-09-14 最終更新日 2022-11-09 実験手法 ELECTRON MICROSCOPY (3.08 Å) 主引用文献 Structural Basis of Peptide-Based Antimicrobial Inhibition of a Resistance-Nodulation-Cell Division Multidrug Efflux Pump. Microbiol Spectr, 10, 2022
1JTX	Crystal structure of the multidrug binding transcriptional regulator QacR bound to crystal violet 分子名称: CRYSTAL VIOLET, HYPOTHETICAL TRANSCRIPTIONAL REGULATOR IN QACA 5'REGION, SULFATE ION 著者 Schumacher, M.A, Miller, M.C, Grkovic, S, Brown, M.H, Skurray, R.A, Brennan, R.G. 登録日 2001-08-22 公開日 2001-12-07 最終更新日 2023-08-16 実験手法 X-RAY DIFFRACTION (2.85 Å) 主引用文献 Structural mechanisms of QacR induction and multidrug recognition. Science, 294, 2001
1JUP	Crystal structure of the multidrug binding transcriptional repressor QacR bound to malachite green 分子名称: HYPOTHETICAL TRANSCRIPTIONAL REGULATOR IN QACA 5'REGION, MALACHITE GREEN, SULFATE ION 著者 Schumacher, M.A, Miller, M.C, Grkovic, S, Brown, M.H, Skurray, R.A, Brennan, R.G. 登録日 2001-08-24 公開日 2001-12-12 最終更新日 2023-08-16 実験手法 X-RAY DIFFRACTION (2.95 Å) 主引用文献 Structural mechanisms of QacR induction and multidrug recognition. Science, 294, 2001
5NG5	multi-drug efflux; membrane transport; RND superfamily; Drug resistance 分子名称: 6-[2-(3,4-dimethoxyphenyl)ethylsulfanyl]-8-[4-(2-methoxyethyl)piperazin-1-yl]-3,3-dimethyl-1,4-dihydropyrano[3,4-c]pyridine-5-carbonitrile, Multidrug efflux pump accessory protein AcrZ, Multidrug efflux pump subunit AcrA, ... 著者 Wang, Z, Fan, G, Hryc, C.F, Blaza, J.N, Serysheva, I.I, Schmid, M.F, Chiu, W, Luisi, B.F, Du, D. 登録日 2017-03-16 公開日 2017-04-19 最終更新日 2017-08-02 実験手法 ELECTRON MICROSCOPY (6.5 Å) 主引用文献 An allosteric transport mechanism for the AcrAB-TolC Multidrug Efflux Pump. Elife, 6, 2017
8VXU	Crystal structure of Gdx-Clo A60T from Small Multidrug Resistance family of transporters in complex with cetyltrimetylammonium 分子名称: CETYL-TRIMETHYL-AMMONIUM, L10 Monobody, Multidrug resistance protein, ... 著者 Burata, O.E, Stockbridge, R.B. 登録日 2024-02-06 公開日 2024-05-08 最終更新日 2024-06-26 実験手法 X-RAY DIFFRACTION (2.29 Å) 主引用文献 Peripheral positions encode transport specificity in the small multidrug resistance exporters. Proc.Natl.Acad.Sci.USA, 121, 2024
6VXF	Structure of apo-closed ABCG2 分子名称: Broad substrate specificity ATP-binding cassette transporter ABCG2 著者 Orlando, B.J, Maofu, L. 登録日 2020-02-21 公開日 2020-05-13 最終更新日 2020-05-20 実験手法 ELECTRON MICROSCOPY (3.5 Å) 主引用文献 ABCG2 transports anticancer drugs via a closed-to-open switch. Nat Commun, 11, 2020
6VXJ	Structure of ABCG2 bound to SN38 分子名称: 7-ethyl-10-hydroxycamptothecin, Broad substrate specificity ATP-binding cassette transporter ABCG2, CHOLESTEROL 著者 Orlando, B.J, Liao, M. 登録日 2020-02-22 公開日 2020-05-13 最終更新日 2020-05-20 実験手法 ELECTRON MICROSCOPY (4.1 Å) 主引用文献 ABCG2 transports anticancer drugs via a closed-to-open switch. Nat Commun, 11, 2020
6VXH	Structure of ABCG2 bound to imatinib 分子名称: 4-(4-METHYL-PIPERAZIN-1-YLMETHYL)-N-[4-METHYL-3-(4-PYRIDIN-3-YL-PYRIMIDIN-2-YLAMINO)-PHENYL]-BENZAMIDE, Broad substrate specificity ATP-binding cassette transporter ABCG2, CHOLESTEROL 著者 Orlando, B.J, Liao, M. 登録日 2020-02-21 公開日 2020-05-13 最終更新日 2020-05-20 実験手法 ELECTRON MICROSCOPY (4 Å) 主引用文献 ABCG2 transports anticancer drugs via a closed-to-open switch. Nat Commun, 11, 2020
6VXI	Structure of ABCG2 bound to mitoxantrone 分子名称: 1,4-DIHYDROXY-5,8-BIS({2-[(2-HYDROXYETHYL)AMINO]ETHYL}AMINO)-9,10-ANTHRACENEDIONE, Broad substrate specificity ATP-binding cassette transporter ABCG2, CHOLESTEROL 著者 Orlando, B.J, Liao, M. 登録日 2020-02-21 公開日 2020-05-13 最終更新日 2020-05-20 実験手法 ELECTRON MICROSCOPY (3.7 Å) 主引用文献 ABCG2 transports anticancer drugs via a closed-to-open switch. Nat Commun, 11, 2020

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