PDB: 169 件ウェブページステータス検索Chemie searchBIRD

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5RZV	EPB41L3 PanDDA analysis group deposition -- Crystal Structure of the FERM domain of human EPB41L3 in complex with Z31504642 分子名称: 1,2-ETHANEDIOL, 2-methoxy-N-phenylacetamide, DIMETHYL SULFOXIDE, ... 著者 Bradshaw, W.J, Katis, V.L, Newman, J.A, von Delft, F, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Gileadi, O. 登録日 2020-10-30 公開日 2020-11-11 最終更新日 2024-03-06 実験手法 X-RAY DIFFRACTION (1.75 Å) 主引用文献 EPB41L3 PanDDA analysis group deposition To Be Published
8GXE	PTPN21 FERM PTP complex 分子名称: CHLORIDE ION, Tyrosine-protein phosphatase non-receptor type 21 著者 Chen, L, Zheng, Y.Y, Zhou, C. 登録日 2022-09-19 公開日 2023-09-27 最終更新日 2024-04-17 実験手法 X-RAY DIFFRACTION (3 Å) 主引用文献 Structural analysis of PTPN21 reveals a dominant-negative effect of the FERM domain on its phosphatase activity. Sci Adv, 10, 2024
5D68	Crystal structure of KRIT1 ARD-FERM 分子名称: Krev interaction trapped protein 1 著者 Zhang, R, Li, X, Boggon, T.J. 登録日 2015-08-11 公開日 2015-10-21 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (2.908 Å) 主引用文献 Structural analysis of the KRIT1 ankyrin repeat and FERM domains reveals a conformationally stable ARD-FERM interface. J.Struct.Biol., 192, 2015
4HDO	Crystal structure of the binary Complex of KRIT1 bound to the Rap1 GTPase 分子名称: GLYCEROL, Krev interaction trapped protein 1, MAGNESIUM ION, ... 著者 Gingras, A.R. 登録日 2012-10-02 公開日 2013-07-10 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (1.67 Å) 主引用文献 The Structure of the Ternary Complex of Krev Interaction Trapped 1 (KRIT1) Bound to Both the Rap1 GTPase and the Heart of Glass (HEG1) Cytoplasmic Tail. J.Biol.Chem., 288, 2013
6OQ3	Crystal Structure of the Ternary Complex of KRIT1 bound to both the Rap1 GTPase and HKi2 分子名称: 2-hydroxynaphthalene-1-carbaldehyde, Krev interaction trapped protein 1, MAGNESIUM ION, ... 著者 Gingras, A.R. 登録日 2019-04-25 公開日 2020-06-24 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (1.85 Å) 主引用文献 Inhibition of the HEG1-KRIT1 interaction increases KLF4 and KLF2 expression in endothelial cells Faseb Bioadv, 2021
6OQ4	Crystal Structure of the Ternary Complex of KRIT1 bound to both the Rap1 GTPase and HKi1 分子名称: 2-{(Z)-[(2-hydroxynaphthalen-1-yl)methylidene]amino}-N-[(1S)-1-phenylethyl]benzamide, Krev interaction trapped protein 1, MAGNESIUM ION, ... 著者 Gingras, A.R. 登録日 2019-04-25 公開日 2020-06-24 最終更新日 2024-03-13 実験手法 X-RAY DIFFRACTION (1.754 Å) 主引用文献 Inhibition of the HEG1-KRIT1 interaction increases KLF4 and KLF2 expression in endothelial cells Faseb Bioadv, 2021
4HDQ	Crystal Structure of the Ternary Complex of KRIT1 bound to both the Rap1 GTPase and the Heart of Glass (HEG1) cytoplasmic tail 分子名称: GLYCEROL, Krev interaction trapped protein 1, MAGNESIUM ION, ... 著者 Gingras, A.R. 登録日 2012-10-02 公開日 2013-07-10 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (1.95 Å) 主引用文献 The Structure of the Ternary Complex of Krev Interaction Trapped 1 (KRIT1) Bound to Both the Rap1 GTPase and the Heart of Glass (HEG1) Cytoplasmic Tail. J.Biol.Chem., 288, 2013
2YS3	Solution structure of the PH domain of Kindlin-3 from human 分子名称: Unc-112-related protein 2 著者 Li, H, Sato, M, Koshiba, S, Watanabe, S, Harada, T, Kigawa, T, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) 登録日 2007-04-03 公開日 2007-10-09 最終更新日 2024-05-29 実験手法 SOLUTION NMR 主引用文献 Solution structure of the PH domain of Kindlin-3 from human To be Published
7C3M	Structure of FERM protein 分子名称: Fermitin family homolog 3,Fermitin family homolog 3,Fermitin family homolog 3 著者 Bu, W, Loh, Z.Y, Jin, S, Basu, S, Ero, R, Park, J.E, Yan, X, Wang, M, Sze, S.K, Tan, S.M, Gao, Y.G. 登録日 2020-05-13 公開日 2020-06-03 最終更新日 2024-03-27 実験手法 X-RAY DIFFRACTION (3.6 Å) 主引用文献 Structural basis of human full-length kindlin-3 homotrimer in an auto-inhibited state. Plos Biol., 18, 2020
6T36	Crystal structure of the PTPN3 PDZ domain bound to the HBV core protein C-terminal peptide 分子名称: BROMIDE ION, Capsid protein, Tyrosine-protein phosphatase non-receptor type 3 著者 Genera, M, Mechaly, A, Haouz, A, Caillet-Saguy, C. 登録日 2019-10-10 公開日 2021-01-20 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (1.86 Å) 主引用文献 Molecular basis of the interaction of the human tyrosine phosphatase PTPN3 with the hepatitis B virus core protein. Sci Rep, 11, 2021
5L81	Crystal structure of the PH domain of murine kindlin-3 分子名称: Fermitin family homolog 3, SODIUM ION 著者 Ni, T, Harlos, K, Gilbert, R.J.C. 登録日 2016-06-06 公開日 2017-01-11 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (2.23 Å) 主引用文献 Structure and lipid-binding properties of the kindlin-3 pleckstrin homology domain. Biochem. J., 474, 2017
4BBK	Structural and functional characterisation of the kindlin-1 pleckstrin homology domain 分子名称: FERMITIN FAMILY HOMOLOG 1, GLYCEROL 著者 Yates, L.A, Lumb, C.N, Brahme, N.N, Zalyte, R, Bird, L.E, De Colibus, L, Owens, R.J, Calderwood, D.A, Sansom, M.S.P, Gilbert, R.J.C. 登録日 2012-09-25 公開日 2012-11-14 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Structural and Functional Characterisation of the Kindlin-1 Pleckstrin Homology Domain J.Biol.Chem., 287, 2012
4DXA	Co-crystal structure of Rap1 in complex with KRIT1 分子名称: 5'-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE, Krev interaction trapped protein 1, MAGNESIUM ION, ... 著者 Li, X, Zhang, R, Boggon, T.J. 登録日 2012-02-27 公開日 2012-05-16 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (1.95 Å) 主引用文献 Structural Basis for Small G Protein Effector Interaction of Ras-related Protein 1 (Rap1) and Adaptor Protein Krev Interaction Trapped 1 (KRIT1). J.Biol.Chem., 287, 2012
4F7H	The crystal structure of kindlin-2 pleckstrin homology domain in free form 分子名称: Fermitin family homolog 2, S,R MESO-TARTARIC ACID 著者 Liu, Y, Zhu, Y, Qin, J, Ye, S, Zhang, R. 登録日 2012-05-16 公開日 2012-06-13 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Crystal structure of kindlin-2 PH domain reveals a conformational transition for its membrane anchoring and regulation of integrin activation. Protein Cell, 3, 2012
2LKO	Structural Basis of Phosphoinositide Binding to Kindlin-2 Pleckstrin Homology Domain in Regulating Integrin Activation 分子名称: Fermitin family homolog 2, INOSITOL-(1,3,4,5)-TETRAKISPHOSPHATE 著者 Liu, J, Fukuda, K, Xu, Z. 登録日 2011-10-17 公開日 2011-10-26 最終更新日 2024-05-15 実験手法 SOLUTION NMR 主引用文献 Structural basis of phosphoinositide binding to kindlin-2 protein pleckstrin homology domain in regulating integrin activation. J.Biol.Chem., 286, 2011
6UZK	Crystal Structure of the Ternary Complex of KRIT1 bound to both the Rap1 GTPase and HKi6 分子名称: 2-hydroxy-6-methoxynaphthalene-1-carbaldehyde, Krev interaction trapped protein 1, MAGNESIUM ION, ... 著者 Gingras, A.R. 登録日 2019-11-15 公開日 2020-11-18 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (1.924 Å) 主引用文献 Inhibition of the HEG1-KRIT1 interaction increases KLF4 and KLF2 expression in endothelial cells. Faseb Bioadv, 3, 2021
8SU8	Co-crystal structure of KRIT1 with a 1-hydroxy 2-naphthaldehyde derivative (6-(furan-2-yl)-2-hydroxy-1-naphthaldehyde). 分子名称: (6P)-6-(furan-2-yl)-2-hydroxynaphthalene-1-carbaldehyde, Krev interaction trapped protein 1, MAGNESIUM ION, ... 著者 Bruystens, J.G.H. 登録日 2023-05-11 公開日 2023-12-06 実験手法 X-RAY DIFFRACTION (2.01 Å) 主引用文献 Targeted Reversible Covalent Modification of a Noncatalytic Lysine of the Krev Interaction Trapped 1 Protein Enables Site-Directed Screening for Protein-Protein Interaction Inhibitors. Acs Pharmacol Transl Sci, 6, 2023
8T7V	Co-crystal structure of KRIT1 with a 1-hydroxy 2-naphthaldehyde derivative (6-(furan-2-yl)-2-hydroxy-1-naphthaldehyde) 分子名称: (7M)-7-(furan-2-yl)-2-hydroxynaphthalene-1-carbaldehyde, Krev interaction trapped protein 1, MAGNESIUM ION, ... 著者 Bruystens, J.G.H. 登録日 2023-06-21 公開日 2023-12-06 実験手法 X-RAY DIFFRACTION (2.25 Å) 主引用文献 Targeted Reversible Covalent Modification of a Noncatalytic Lysine of the Krev Interaction Trapped 1 Protein Enables Site-Directed Screening for Protein-Protein Interaction Inhibitors. Acs Pharmacol Transl Sci, 6, 2023
8T09	Co-crystal structure of KRIT1 with a 1-hydroxy 2-naphthaldehyde derivative (6-ethynyl-2-hydroxy-1-naphthaldehyde) 分子名称: 6-ethynyl-2-hydroxynaphthalene-1-carbaldehyde, Krev interaction trapped protein 1, MAGNESIUM ION, ... 著者 Bruystens, J.G.H. 登録日 2023-05-31 公開日 2023-12-13 実験手法 X-RAY DIFFRACTION (2.15 Å) 主引用文献 Targeted Reversible Covalent Modification of a Noncatalytic Lysine of the Krev Interaction Trapped 1 Protein Enables Site-Directed Screening for Protein-Protein Interaction Inhibitors. Acs Pharmacol Transl Sci, 6, 2023

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