8T09

Co-crystal structure of KRIT1 with a 1-hydroxy 2-naphthaldehyde derivative (6-ethynyl-2-hydroxy-1-naphthaldehyde)

Summary for 8T09

• Entry DOI: 10.2210/pdb8t09/pdb
• Related: 8SU8
• Descriptor: Krev interaction trapped protein 1, Ras-related protein Rap-1b, 6-ethynyl-2-hydroxynaphthalene-1-carbaldehyde, ... (6 entities in total)
• Functional Keywords: complex, inhibitor, cell adhesion
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 2
• Total formula weight: 56781.14

Authors

Bruystens, J.G.H. (deposition date: 2023-05-31, release date: 2023-12-13)

• Primary citation: Francisco, K.R.,Bruystens, J.,Varricchio, C.,McCurdy, S.,Wu, J.,Lopez-Ramirez, M.A.,Ginsberg, M.,Caffrey, C.R.,Brancale, A.,Gingras, A.R.,Hixon, M.S.,Ballatore, C.; Targeted Reversible Covalent Modification of a Noncatalytic Lysine of the Krev Interaction Trapped 1 Protein Enables Site-Directed Screening for Protein-Protein Interaction Inhibitors.; Acs Pharmacol Transl Sci, 6:1651-1658, 2023; PubMed: 37974623; DOI: 10.1021/acsptsci.3c00156

Experimental method

X-RAY DIFFRACTION (2.15 Å)