6PXV
 
 | | Cryo-EM structure of full-length insulin receptor bound to 4 insulin. 3D refinement was focused on the extracellular region. | | 分子名称: | Insulin, Insulin receptor | | 著者 | Uchikawa, E, Choi, E, Shang, G.J, Yu, H.T, Bai, X.C. | | 登録日 | 2019-07-27 | | 公開日 | 2019-09-04 | | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | | 主引用文献 | Activation mechanism of the insulin receptor revealed by cryo-EM structure of the fully liganded receptor-ligand complex.
Elife, 8, 2019
|
|
6POL
 | | Crystal structure of the human NELL1 EGF1-3-Robo3 FN1 complex | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, GLYCEROL, ... | | 著者 | Wang, J, Pak, J.S, Ozkan, E. | | 登録日 | 2019-07-04 | | 公開日 | 2020-05-06 | | 最終更新日 | 2023-10-11 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | NELL2-Robo3 complex structure reveals mechanisms of receptor activation for axon guidance.
Nat Commun, 11, 2020
|
|
6POK
 | |
6POG
 | | Crystal structure of the NELL2 EGF1-6-Robo3 FN1 complex | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ... | | 著者 | Wang, J, Pak, J.S, Ozkan, E. | | 登録日 | 2019-07-03 | | 公開日 | 2020-05-06 | | 最終更新日 | 2020-07-29 | | 実験手法 | X-RAY DIFFRACTION (2.755 Å) | | 主引用文献 | NELL2-Robo3 complex structure reveals mechanisms of receptor activation for axon guidance.
Nat Commun, 11, 2020
|
|
6P67
 | | Crystal Structure of a Complex of human IL-7Ralpha with an anti-IL-7Ralpha 2B8 Fab | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Anti-IL-7R 2B8 Fab heavy chain, ... | | 著者 | Walsh, S.T.R, Kashi, L, Kohnhorst, C.L. | | 登録日 | 2019-06-03 | | 公開日 | 2019-09-04 | | 最終更新日 | 2024-03-13 | | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | | 主引用文献 | New anti-IL-7R alpha monoclonal antibodies show efficacy against T cell acute lymphoblastic leukemia in pre-clinical models.
Leukemia, 34, 2020
|
|
6P50
 | | Crystal Structure of a Complex of human IL-7Ralpha with an anti-IL-7Ralpha Fab 4A10 | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Interleukin-7 receptor subunit alpha, anti-IL-7R 4A10 Fab heavy chain, ... | | 著者 | Walsh, S.T.R, Kashi, L, Kohnhorst, C.L. | | 登録日 | 2019-05-29 | | 公開日 | 2019-09-04 | | 最終更新日 | 2023-10-11 | | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | | 主引用文献 | New anti-IL-7R alpha monoclonal antibodies show efficacy against T cell acute lymphoblastic leukemia in pre-clinical models.
Leukemia, 34, 2020
|
|
6NAJ
 | |
6IAA
 | | hRobo2 ectodomain | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Roundabout homolog 2, alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | | 著者 | Barak, R, Isupov, N.M, Opatowsky, Y. | | 登録日 | 2018-11-26 | | 公開日 | 2019-03-13 | | 最終更新日 | 2020-07-29 | | 実験手法 | X-RAY DIFFRACTION (3.6 Å) | | 主引用文献 | Structural Principles in Robo Activation and Auto-inhibition.
Cell, 177, 2019
|
|
6HYF
 | |
6MSV
 | |
6MOJ
 | | Dimeric DARPin A_angle_R5 complex with EpoR | | 分子名称: | D(-)-TARTARIC ACID, Dimeric DARPin ACR5 (A_angle_R5), Erythropoietin receptor, ... | | 著者 | Jude, K.M, Mohan, K, Garcia, K.C. | | 登録日 | 2018-10-04 | | 公開日 | 2019-06-05 | | 最終更新日 | 2023-10-11 | | 実験手法 | X-RAY DIFFRACTION (2.431 Å) | | 主引用文献 | Topological control of cytokine receptor signaling induces differential effects in hematopoiesis.
Science, 364, 2019
|
|
6MOK
 | | Dimeric DARPin A_distance_R7 complex with EpoR | | 分子名称: | Dimeric DARPin ANR7 (A_distance_r7), Erythropoietin receptor | | 著者 | Jude, K.M, Mohan, K, Garcia, K.C, Guo, Y. | | 登録日 | 2018-10-04 | | 公開日 | 2019-06-05 | | 最終更新日 | 2023-10-11 | | 実験手法 | X-RAY DIFFRACTION (5.101 Å) | | 主引用文献 | Topological control of cytokine receptor signaling induces differential effects in hematopoiesis.
Science, 364, 2019
|
|
6MOH
 | | Dimeric DARPin C_R3 complex with EpoR | | 分子名称: | Dimeric DARPin E2C (C_R3), Erythropoietin receptor, PHOSPHATE ION, ... | | 著者 | Jude, K.M, Mohan, K, Garcia, K.C. | | 登録日 | 2018-10-04 | | 公開日 | 2019-06-05 | | 最終更新日 | 2023-10-11 | | 実験手法 | X-RAY DIFFRACTION (3.2 Å) | | 主引用文献 | Topological control of cytokine receptor signaling induces differential effects in hematopoiesis.
Science, 364, 2019
|
|
6MOI
 | | Dimeric DARPin C_angle_R5 complex with EpoR | | 分子名称: | 1,2-ETHANEDIOL, DI(HYDROXYETHYL)ETHER, Dimeric DARPing CCR5 (C_angle_R5), ... | | 著者 | Jude, K.M, Mohan, K, Garcia, K.C, Guo, Y. | | 登録日 | 2018-10-04 | | 公開日 | 2019-06-05 | | 最終更新日 | 2023-10-11 | | 実験手法 | X-RAY DIFFRACTION (2.065 Å) | | 主引用文献 | Topological control of cytokine receptor signaling induces differential effects in hematopoiesis.
Science, 364, 2019
|
|
6MOE
 | | Monomeric DARPin E2 complex with EpoR | | 分子名称: | 1,2-ETHANEDIOL, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, E2 DARPin, ... | | 著者 | Jude, K.M, Mohan, K, Garcia, K.C. | | 登録日 | 2018-10-04 | | 公開日 | 2019-06-05 | | 最終更新日 | 2023-10-11 | | 実験手法 | X-RAY DIFFRACTION (2.091 Å) | | 主引用文献 | Topological control of cytokine receptor signaling induces differential effects in hematopoiesis.
Science, 364, 2019
|
|
6MOL
 | | Monoextended DARPin M_R12 complex with EpoR | | 分子名称: | Erythropoietin receptor, GLYCEROL, Monoextended DARPin R12 (M_R12) | | 著者 | Jude, K.M, Mohan, K, Garcia, K.C, Guo, Y. | | 登録日 | 2018-10-04 | | 公開日 | 2019-06-05 | | 最終更新日 | 2023-10-11 | | 実験手法 | X-RAY DIFFRACTION (3.163 Å) | | 主引用文献 | Topological control of cytokine receptor signaling induces differential effects in hematopoiesis.
Science, 364, 2019
|
|
6MOF
 | | Monomeric DARPin G2 complex with EpoR | | 分子名称: | 1,2-ETHANEDIOL, Erythropoietin receptor, G2 DARPin | | 著者 | Jude, K.M, Mohan, K, Garcia, K.C. | | 登録日 | 2018-10-04 | | 公開日 | 2019-06-05 | | 最終更新日 | 2023-10-11 | | 実験手法 | X-RAY DIFFRACTION (2.894 Å) | | 主引用文献 | Topological control of cytokine receptor signaling induces differential effects in hematopoiesis.
Science, 364, 2019
|
|
6HN4
 | | Leucine-zippered human insulin receptor ectodomain with single bound insulin - "lower" membrane-proximal part | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Insulin receptor,Insulin receptor,General control protein GCN4 | | 著者 | Weis, F, Menting, J.G, Margetts, M.B, Chan, S.J, Xu, Y, Tennagels, N, Wohlfart, P, Langer, T, Mueller, C.W, Dreyer, M.K, Lawrence, M.C. | | 登録日 | 2018-09-14 | | 公開日 | 2018-11-21 | | 最終更新日 | 2022-03-30 | | 実験手法 | ELECTRON MICROSCOPY (4.2 Å) | | 主引用文献 | The signalling conformation of the insulin receptor ectodomain.
Nat Commun, 9, 2018
|
|
6HNF
 | | Structure in solution of human fibronectin type III-domain 14 | | 分子名称: | Fibronectin | | 著者 | Zhong, X, Arnolds, O, Krenczyk, O, Gajewski, J, Puetz, S, Herrmann, C, Stoll, R. | | 登録日 | 2018-09-14 | | 公開日 | 2018-10-10 | | 最終更新日 | 2024-06-19 | | 実験手法 | SOLUTION NMR | | 主引用文献 | The Structure in Solution of Fibronectin Type III Domain 14 Reveals Its Synergistic Heparin Binding Site.
Biochemistry, 57, 2018
|
|
6HN5
 | | Leucine-zippered human insulin receptor ectodomain with single bound insulin - "upper" membrane-distal part | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Insulin, ... | | 著者 | Weis, F, Menting, J.G, Margetts, M.B, Chan, S.J, Xu, Y, Tennagels, N, Wohlfart, P, Langer, T, Mueller, C.W, Dreyer, M.K, Lawrence, M.C. | | 登録日 | 2018-09-14 | | 公開日 | 2018-11-21 | | 最終更新日 | 2022-03-30 | | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | | 主引用文献 | The signalling conformation of the insulin receptor ectodomain.
Nat Commun, 9, 2018
|
|
6MFA
 | |
6GVK
 | | Second pair of Fibronectin type III domains of integrin beta4 (T1663R mutant) bound to the bullous pemphigoid antigen BP230 (BPAG1e) | | 分子名称: | Dystonin, GLYCEROL, Integrin beta-4 | | 著者 | Manso, J.A, Gomez-Hernandez, M, Alonso-Garcia, N, de Pereda, J.M. | | 登録日 | 2018-06-21 | | 公開日 | 2019-03-20 | | 最終更新日 | 2024-01-17 | | 実験手法 | X-RAY DIFFRACTION (1.55 Å) | | 主引用文献 | Integrin alpha 6 beta 4 Recognition of a Linear Motif of Bullous Pemphigoid Antigen BP230 Controls Its Recruitment to Hemidesmosomes.
Structure, 27, 2019
|
|
6GVL
 | | Second pair of Fibronectin type III domains of integrin beta4 bound to the bullous pemphigoid antigen BP230 (BPAG1e) | | 分子名称: | Dystonin, Integrin beta-4 | | 著者 | Manso, J.A, Gomez-Hernandez, M, Alonso-Garcia, N, de Pereda, J.M. | | 登録日 | 2018-06-21 | | 公開日 | 2019-03-20 | | 最終更新日 | 2024-05-01 | | 実験手法 | X-RAY DIFFRACTION (2.05 Å) | | 主引用文献 | Integrin alpha 6 beta 4 Recognition of a Linear Motif of Bullous Pemphigoid Antigen BP230 Controls Its Recruitment to Hemidesmosomes.
Structure, 27, 2019
|
|
6CE9
 | | Insulin Receptor ectodomain in complex with two insulin molecules | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | 著者 | Scapin, G, Dandey, V.P, Zhang, Z, Strickland, C, Potter, C.S, Carragher, B. | | 登録日 | 2018-02-11 | | 公開日 | 2018-03-14 | | 最終更新日 | 2020-07-29 | | 実験手法 | ELECTRON MICROSCOPY (4.3 Å) | | 主引用文献 | Structure of the insulin receptor-insulin complex by single-particle cryo-EM analysis.
Nature, 556, 2018
|
|
6CEB
 | | Insulin Receptor ectodomain in complex with two insulin molecules - C1 symmetry | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | 著者 | Scapin, G, Dandey, V.P, Zhang, Z, Strickland, C, Potter, C.S, Carragher, B. | | 登録日 | 2018-02-11 | | 公開日 | 2018-03-14 | | 最終更新日 | 2020-07-29 | | 実験手法 | ELECTRON MICROSCOPY (4.7 Å) | | 主引用文献 | Structure of the insulin receptor-insulin complex by single-particle cryo-EM analysis.
Nature, 556, 2018
|
|
