PDB: 47065 件ウェブページステータス検索Chemie searchBIRD

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4OIV	Structural basis for small molecule NDB as a selective antagonist of FXR 分子名称: Bile acid receptor, N-benzyl-N-(3-tert-butyl-4-hydroxyphenyl)-2,6-dichloro-4-(dimethylamino)benzamide 著者 Xu, X, Chen, L, Hu, L, Shen, X. 登録日 2014-01-20 公開日 2015-03-25 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 Structural Basis for Small Molecule NDB (N-Benzyl-N-(3-(tert-butyl)-4-hydroxyphenyl)-2,6-dichloro-4-(dimethylamino) Benzamide) as a Selective Antagonist of Farnesoid X Receptor alpha (FXR alpha ) in Stabilizing the Homodimerization of the Receptor. J.Biol.Chem., 290, 2015
3HS0	Cobra Venom Factor (CVF) in complex with human factor B 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Cobra venom factor, ... 著者 Janssen, B.J.C, Gomes, L, Koning, R.I, Svergun, D.I, Koster, A.J, Fritzinger, D.C, Vogel, C.-W, Gros, P. 登録日 2009-06-10 公開日 2009-07-07 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (3 Å) 主引用文献 Insights into complement convertase formation based on the structure of the factor B-cobra venom factor complex Embo J., 28, 2009
7BRM	Architecture of curli complex 分子名称: Curli production assembly/transport protein CsgG, csgf 著者 Zhang, M, Shi, H. 登録日 2020-03-29 公開日 2020-07-15 最終更新日 2024-03-27 実験手法 ELECTRON MICROSCOPY (3.6 Å) 主引用文献 Cryo-EM structure of the nonameric CsgG-CsgF complex and its implications for controlling curli biogenesis in Enterobacteriaceae. Plos Biol., 18, 2020
5LW9	Crystal structure of human JARID1B in complex with S40563a 分子名称: 1,2-ETHANEDIOL, 8-[4-[2-[4-[3,5-bis(chloranyl)phenyl]piperidin-1-yl]ethyl]pyrazol-1-yl]-3~{H}-pyrido[3,4-d]pyrimidin-4-one, DIMETHYL SULFOXIDE, ... 著者 Srikannathasan, V, Le Bihan, Y.V, Szykowska, A, Johansson, C, Gileadi, C, Arrowsmith, C.H, Edwards, A.M, Bountra, C, von Delft, F, Oppermann, U, Huber, K. 登録日 2016-09-15 公開日 2016-09-28 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Crystal structure of human JARID1B in complex with S40563a to be published
5LEZ	Human 20S proteasome complex with Oprozomib in Mg-Acetate at 2.2 Angstrom 分子名称: ACETATE ION, MAGNESIUM ION, PENTAETHYLENE GLYCOL, ... 著者 Schrader, J, Henneberg, F, Mata, R, Tittmann, K, Schneider, T.R, Stark, H, Bourenkov, G, Chari, A. 登録日 2016-06-30 公開日 2016-08-17 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (2.19 Å) 主引用文献 The inhibition mechanism of human 20S proteasomes enables next-generation inhibitor design. Science, 353, 2016
1XJT	Crystal structure of active form of P1 phage endolysin Lyz 分子名称: CITRIC ACID, Lysozyme 著者 Arockiasamy, A, Sacchettini, J.C. 登録日 2004-09-24 公開日 2005-01-11 最終更新日 2017-10-11 実験手法 X-RAY DIFFRACTION (1.75 Å) 主引用文献 Disulfide isomerization after membrane release of its SAR domain activates P1 lysozyme. Science, 307, 2005
4HG4	Crystal structure of Fab 2G1 in complex with a H2N2 influenza virus hemagglutinin 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Fab 2G1 heavy chain, ... 著者 Xu, R, Wilson, I.A. 登録日 2012-10-06 公開日 2013-02-13 最終更新日 2020-07-29 実験手法 X-RAY DIFFRACTION (3.2 Å) 主引用文献 A recurring motif for antibody recognition of the receptor-binding site of influenza hemagglutinin. Nat.Struct.Mol.Biol., 20, 2013
4HHD	2.75 Angstrom resolution crystal structure of the A. thaliana LOV2 domain with an extended N-terminal A' helix (cryo dark structure) 分子名称: FLAVIN MONONUCLEOTIDE, Phototropin-1, SODIUM ION 著者 Halavaty, A.S, Moffat, K. 登録日 2012-10-09 公開日 2013-10-09 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (2.75 Å) 主引用文献 Coiled-coil dimerization of the LOV2 domain of the blue-light photoreceptor phototropin 1 from Arabidopsis thaliana. Acta Crystallogr.,Sect.F, 69, 2013
5LLM	Structure of the thermostabilized EAAT1 cryst mutant in complex with L-ASP and the allosteric inhibitor UCPH101 分子名称: 2-Amino-5,6,7,8-tetrahydro-4-(4-methoxyphenyl)-7-(naphthalen-1-yl)-5-oxo-4H-chromene-3-carbonitrile, ASPARTIC ACID, Excitatory amino acid transporter 1,Neutral amino acid transporter B(0),Excitatory amino acid transporter 1, ... 著者 Canul-Tec, J, Assal, R, Legrand, P, Reyes, N. 登録日 2016-07-27 公開日 2017-04-19 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (3.25 Å) 主引用文献 Structure and allosteric inhibition of excitatory amino acid transporter 1. Nature, 544, 2017
3L3U	Crystal structure of the HIV-1 integrase core domain to 1.4A 分子名称: POL polyprotein, SULFATE ION 著者 Wielens, J, Chalmers, D.K, Scanlon, M.J, Parker, M.W. 登録日 2009-12-17 公開日 2010-03-31 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (1.4 Å) 主引用文献 Crystal structure of the HIV-1 integrase core domain in complex with sucrose reveals details of an allosteric inhibitory binding site. Febs Lett., 584, 2010
4IK9	High resolution structure of GCaMP3 dimer form 2 at pH 7.5 分子名称: CALCIUM ION, DI(HYDROXYETHYL)ETHER, RCaMP, ... 著者 Chen, Y, Song, X, Miao, L, Zhu, Y, Ji, G. 登録日 2012-12-25 公開日 2014-01-29 最終更新日 2017-06-21 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Structural insight into enhanced calcium indicator GCaMP3 and GCaMPJ to promote further improvement. Protein Cell, 4, 2013
4OIN	Crystal structure of Thermus thermophilus transcription initiation complex soaked with GE23077 分子名称: (2Z)-2-methylbut-2-enoic acid, 5'-D(*CP*CP*T*GP*CP*AP*TP*CP*CP*GP*TP*GP*AP*GP*TP*CP*GP*AP*G)-3', 5'-D(*TP*AP*TP*AP*AP*TP*GP*GP*GP*AP*GP*CP*TP*GP*TP*CP*AP*CP*GP*GP*AP*TP*GP*CP*AP*GP*G)-3', ... 著者 Zhang, Y, Ebright, R.H, Arnold, E. 登録日 2014-01-20 公開日 2014-05-07 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 GE23077 binds to the RNA polymerase 'i' and 'i+1' sites and prevents the binding of initiating nucleotides. Elife, 3, 2014
1XZN	PYRR, THE REGULATOR OF THE PYRIMIDINE BIOSYNTHETIC OPERON IN BACILLUS CALDOLYTICUS, sulfate-bound form 分子名称: MAGNESIUM ION, PyrR bifunctional protein, SULFATE ION 著者 Chander, P, Halbig, K.M, Miller, J.K, Fields, C.J, Bonner, H.K, Grabner, G.K, Switzer, R.L, Smith, J.L. 登録日 2004-11-12 公開日 2005-03-01 最終更新日 2023-08-23 実験手法 X-RAY DIFFRACTION (2.27 Å) 主引用文献 Structure of the Nucleotide Complex of PyrR, the pyr Attenuation Protein from Bacillus caldolyticus, Suggests Dual Regulation by Pyrimidine and Purine Nucleotides. J.Bacteriol., 187, 2005
4IK8	High resolution structure of GCaMP3 dimer form 1 at pH 7.5 分子名称: CALCIUM ION, RCaMP, Green fluorescent protein 著者 Chen, Y, Song, X, Miao, L, Zhu, Y, Ji, G. 登録日 2012-12-25 公開日 2014-02-05 最終更新日 2017-06-21 実験手法 X-RAY DIFFRACTION (1.55 Å) 主引用文献 Structural insight into enhanced calcium indicator GCaMP3 and GCaMPJ to promote further improvement. Protein Cell, 4, 2013
4IQB	High Resolution Crystal Structure of C.elegans Thymidylate Synthase 分子名称: SULFATE ION, Thymidylate synthase 著者 Wilk, P, Dowiercial, A, Banaszak, K, Jarmula, A, Rypniewski, W, Rode, W. 登録日 2013-01-11 公開日 2014-01-22 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (1.13 Å) 主引用文献 Crystal structures of nematode (parasitic T. spiralis and free living C. elegans), compared to mammalian, thymidylate synthases (TS). Molecular docking and molecular dynamics simulations in search for nematode-specific inhibitors of TS. J. Mol. Graph. Model., 77, 2017
7BOA	A hexameric de novo coiled-coil assembly: CC-Type2-(YaFd)4-W19(BrPhe). 分子名称: CC-Type2-(YaFd)4-W19(BrPhe) 著者 Rhys, G.G, Martin, F.J.O, Brady, R.L, Woolfson, D.N. 登録日 2021-01-24 公開日 2021-05-19 実験手法 X-RAY DIFFRACTION (1.65 Å) 主引用文献 How Coiled-Coil Assemblies Accommodate Multiple Aromatic Residues. Biomacromolecules, 22, 2021
1XYG	X-RAY STRUCTURE OF GENE PRODUCT FROM ARABIDOPSIS THALIANA AT2G19940 分子名称: putative N-acetyl-gamma-glutamyl-phosphate reductase 著者 Wesenberg, G.E, Phillips Jr, G.N, Bitto, E, Bingman, C.A, Allard, S.T.M, Center for Eukaryotic Structural Genomics (CESG) 登録日 2004-11-09 公開日 2004-11-23 最終更新日 2023-08-23 実験手法 X-RAY DIFFRACTION (2.19 Å) 主引用文献 X-RAY STRUCTURE OF GENE PRODUCT FROM ARABIDOPSIS THALIANA AT2G19940 To be Published
5POP	PanDDA analysis group deposition -- Crystal Structure of BRD1 in complex with N10987a 分子名称: 1,2-ETHANEDIOL, 1-[4-(pyridin-4-yl)piperazin-1-yl]ethan-1-one, Bromodomain-containing protein 1, ... 著者 Pearce, N.M, Krojer, T, Talon, R, Bradley, A.R, Fairhead, M, Sethi, R, Wright, N, MacLean, E, Collins, P, Brandao-Neto, J, Douangamath, A, Renjie, Z, Dias, A, Ng, J, Brennan, P.E, Cox, O, Bountra, C, Arrowsmith, C.H, Edwards, A, von Delft, F. 登録日 2017-02-07 公開日 2017-03-15 最終更新日 2024-03-06 実験手法 X-RAY DIFFRACTION (1.579 Å) 主引用文献 A multi-crystal method for extracting obscured crystallographic states from conventionally uninterpretable electron density. Nat Commun, 8, 2017
4RH3	AMPPCP-bound structure of human platelet phosphofructokinase in an R-state, crystal form II 分子名称: ATP-dependent 6-phosphofructokinase, platelet type, PHOSPHATE ION, ... 著者 Kloos, M. 登録日 2014-10-01 公開日 2015-06-24 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (3.02 Å) 主引用文献 Crystal structure of human platelet phosphofructokinase-1 locked in an activated conformation. Biochem.J., 469, 2015
5M0C	Cocrystal structure of cAMP-dependent Protein Kinase (PKA) in complex with the Fasudil-fragment isoquinoline-5-sulfonamide 分子名称: (4R)-2-METHYLPENTANE-2,4-DIOL, DIMETHYL SULFOXIDE, cAMP-dependent protein kinase catalytic subunit alpha, ... 著者 Wienen-Schmidt, B, Heine, A, Klebe, G. 登録日 2016-10-04 公開日 2018-06-06 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (1.734 Å) 主引用文献 Cocrystal structure of cAMP-dependent Protein Kinase (PKA) in complex with different Fasudil-derivatives To be Published
3L3K	Crystal structure of HLA-B*4402 in complex with the R5A/F7A double mutant of a self-peptide derived from DPA*0201 分子名称: Beta-2-microglobulin, GLYCEROL, HLA class I histocompatibility antigen, ... 著者 Theodossis, A, Ely, L.K, Rossjohn, J. 登録日 2009-12-17 公開日 2010-03-16 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 Constraints within major histocompatibility complex class I restricted peptides: presentation and consequences for T-cell recognition Proc.Natl.Acad.Sci.USA, 107, 2010
5M0L	Cocrystal structure of cAMP-dependent Protein Kinase (PKA) in complex with the methylated Fasudil-derived fragment N-methylisoquinoline-5-sulfonamide (Ligand 02) 分子名称: (4S)-2-METHYL-2,4-PENTANEDIOL, cAMP-dependent protein kinase catalytic subunit alpha, cAMP-dependent protein kinase inhibitor alpha, ... 著者 Wienen-Schmidt, B, Heine, A, Klebe, G. 登録日 2016-10-05 公開日 2018-06-06 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (1.465 Å) 主引用文献 Cocrystal structure of cAMP-dependent Protein Kinase (PKA) in complex with different Fasudil-derivatives To Be Published
3L4N	Crystal structure of yeast monothiol glutaredoxin Grx6 分子名称: GLUTATHIONE, Monothiol glutaredoxin-6 著者 Luo, M, Jiang, Y.-L, Ma, X.-X, He, Y.-X, Tang, Y.-J, Yu, J, Zhang, R.-G, Chen, Y, Zhou, C.-Z. 登録日 2009-12-21 公開日 2010-04-07 最終更新日 2011-12-14 実験手法 X-RAY DIFFRACTION (1.5 Å) 主引用文献 Structural and biochemical characterization of yeast monothiol glutaredoxin Grx6 J.Mol.Biol., 398, 2010
3OMK	Crystal structure of human FXR in complex with (2S)-2-[2-(4-chlorophenyl)-5,6-difluoro-1H-benzimidazol-1-yl]-2-cyclohexyl-N-(2-methylphenyl)ethanamide 分子名称: (2S)-2-[2-(4-chlorophenyl)-5,6-difluoro-1H-benzimidazol-1-yl]-2-cyclohexyl-N-(2-methylphenyl)ethanamide, Bile acid receptor, peptide of Nuclear receptor coactivator 1 著者 Rudolph, M.G. 登録日 2010-08-27 公開日 2011-01-19 最終更新日 2024-04-03 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Optimization of a novel class of benzimidazole-based farnesoid X receptor (FXR) agonists to improve physicochemical and ADME properties Bioorg.Med.Chem.Lett., 21, 2011
3LKF	LEUKOCIDIN F (HLGB) FROM STAPHYLOCOCCUS AUREUS WITH PHOSPHOCHOLINE BOUND 分子名称: LEUKOCIDIN F SUBUNIT, PHOSPHOCHOLINE 著者 Olson, R, Nariya, H, Yokota, K, Kamio, Y, Gouaux, J.E. 登録日 1998-07-28 公開日 1999-07-28 最終更新日 2024-04-03 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Crystal structure of staphylococcal LukF delineates conformational changes accompanying formation of a transmembrane channel. Nat.Struct.Biol., 6, 1999

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