4IQB

High Resolution Crystal Structure of C.elegans Thymidylate Synthase

Summary for 4IQB

Entry DOI	10.2210/pdb4iqb/pdb
Related	3IHH 3IHI 4EB4 4G9U 4IQQ 4IRR 4ISW
Descriptor	Thymidylate synthase, SULFATE ION (3 entities in total)
Functional Keywords	protein dimer, deoxynucleotide biosynthesis, transferase
Biological source	Caenorhabditis elegans (nematode)
Total number of polymer chains	2
Total formula weight	71903.93
Authors	Wilk, P.,Dowiercial, A.,Banaszak, K.,Jarmula, A.,Rypniewski, W.,Rode, W. (deposition date: 2013-01-11, release date: 2014-01-22, Last modification date: 2024-02-28)
Primary citation	Jarmula, A.,Wilk, P.,Maj, P.,Ludwiczak, J.,Dowiercial, A.,Banaszak, K.,Rypniewski, W.,Ciesla, J.,Dabrowska, M.,Fraczyk, T.,Bronowska, A.K.,Jakowiecki, J.,Filipek, S.,Rode, W. Crystal structures of nematode (parasitic T. spiralis and free living C. elegans), compared to mammalian, thymidylate synthases (TS). Molecular docking and molecular dynamics simulations in search for nematode-specific inhibitors of TS. J. Mol. Graph. Model., 77:33-50, 2017 Cited by PubMed: 28826032 DOI: 10.1016/j.jmgm.2017.08.008 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.13 Å)

Structure validation