4IQB

High Resolution Crystal Structure of C.elegans Thymidylate Synthase

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004799	molecular_function	thymidylate synthase activity
A	0006231	biological_process	dTMP biosynthetic process
A	0006235	biological_process	dTTP biosynthetic process
A	0008168	molecular_function	methyltransferase activity
A	0009165	biological_process	nucleotide biosynthetic process
A	0016741	molecular_function	transferase activity, transferring one-carbon groups
A	0032259	biological_process	methylation
B	0004799	molecular_function	thymidylate synthase activity
B	0006231	biological_process	dTMP biosynthetic process
B	0006235	biological_process	dTTP biosynthetic process
B	0008168	molecular_function	methyltransferase activity
B	0009165	biological_process	nucleotide biosynthetic process
B	0016741	molecular_function	transferase activity, transferring one-carbon groups
B	0032259	biological_process	methylation

Functional Information from PDB Data

site_id	AC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 A 401

Chain	Residue
A	LEU194
A	ARG217
B	ARG177
B	ARG178
B	HOH680

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site_id	AC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 B 401

Chain	Residue
B	HOH975
A	ARG178
B	LEU194
B	ARG217
B	HOH742

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Functional Information from PROSITE/UniProt

site_id	PS00091
Number of Residues	29
Details	THYMIDYLATE_SYNTHASE Thymidylate synthase active site. RriImsaWNpsdlgqmv.....LpPCHtmcQFyV

Chain	Residue	Details
A	ARG177-VAL205

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