5M0L

Cocrystal structure of cAMP-dependent Protein Kinase (PKA) in complex with the methylated Fasudil-derived fragment N-methylisoquinoline-5-sulfonamide (Ligand 02)

Summary for 5M0L

• Entry DOI: 10.2210/pdb5m0l/pdb
• Related: 5LCP 5LCQ 5LCR 5LCT 5LCU 5M0B 5M0C
• Descriptor: cAMP-dependent protein kinase catalytic subunit alpha, cAMP-dependent protein kinase inhibitor alpha, ~{N}-methylisoquinoline-5-sulfonamide, ... (5 entities in total)
• Functional Keywords: pka, kinase, fasudil-derivative, inhibition, cocrystal, 3x-phosphorylated, transferase, ligand 02
• Biological source: Cricetulus griseus (Chinese hamster); More
• Total number of polymer chains: 2
• Total formula weight: 43902.88

Authors

Wienen-Schmidt, B.,Heine, A.,Klebe, G. (deposition date: 2016-10-05, release date: 2018-06-06, Last modification date: 2024-10-16)

• Primary citation: Wienen-Schmidt, B.,Jonker, H.,Gerber, H.-D.,Saxena, K.,Kudlinzki, D.,Sreeramulu, S.,Heine, A.,Schwalbe, H.,Klebe, G.; Cocrystal structure of cAMP-dependent Protein Kinase (PKA) in complex with different Fasudil-derivatives; To Be Published,

Experimental method

X-RAY DIFFRACTION (1.465 Å)