PDB: 45953 件ウェブページステータス検索Chemie searchBIRD

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5DOR	P2 Integrase catalytic domain in space group P21 分子名称: Integrase, PHOSPHATE ION, ZINC ION 著者 Skaar, K, Claesson, M, Odegrip, R, Haggard-Ljungquist, E, Hogbom, M. 登録日 2015-09-11 公開日 2015-12-02 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Crystal structure of the bacteriophage P2 integrase catalytic domain. Febs Lett., 589, 2015
4U0V	Crystal structure of YvoA from Bacillus subtilis in complex with glucosamine-6-phosphate 分子名称: 1,2-ETHANEDIOL, 2-amino-2-deoxy-6-O-phosphono-alpha-D-glucopyranose, HTH-type transcriptional repressor YvoA 著者 Fillenberg, S.B, Muller, Y.A. 登録日 2014-07-14 公開日 2015-01-14 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (2.051 Å) 主引用文献 Structural insight into operator dre-sites recognition and effector binding in the GntR/HutC transcription regulator NagR. Nucleic Acids Res., 43, 2015
4U0W	Crystal structure of YvoA from Bacillus subtilis in complex with N-acetylglucosamine-6-phosphate 分子名称: 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-6-O-phosphono-alpha-D-glucopyranose, GLYCEROL, ... 著者 Fillenberg, S.B, Muller, Y.A. 登録日 2014-07-14 公開日 2015-01-14 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (2.001 Å) 主引用文献 Structural insight into operator dre-sites recognition and effector binding in the GntR/HutC transcription regulator NagR. Nucleic Acids Res., 43, 2015
3KQL	Three Conformational Snapshots of the Hepatitis C Virus NS3 Helicase Reveal a Ratchet Translocation Mechanism 分子名称: 5'-D(*TP*TP*TP*TP*TP*T)-3', ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ... 著者 Gu, M, Rice, C.M. 登録日 2009-11-17 公開日 2010-01-26 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Three conformational snapshots of the hepatitis C virus NS3 helicase reveal a ratchet translocation mechanism. Proc.Natl.Acad.Sci.USA, 107, 2010
3KQN	Three Conformational Snapshots of the Hepatitis C Virus NS3 Helicase Reveal a Ratchet Translocation Mechanism 分子名称: 5'-D(*TP*TP*TP*TP*TP*T)-3', ADENOSINE-5'-DIPHOSPHATE, BERYLLIUM TRIFLUORIDE ION, ... 著者 Gu, M, Rice, C.M. 登録日 2009-11-17 公開日 2010-01-26 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (2.05 Å) 主引用文献 Three conformational snapshots of the hepatitis C virus NS3 helicase reveal a ratchet translocation mechanism. Proc.Natl.Acad.Sci.USA, 107, 2010
3KQU	Three Conformational Snapshots of the Hepatitis C Virus NS3 Helicase Reveal a Ratchet Translocation Mechanism 分子名称: 5'-D(*T*TP*TP*TP*TP*TP*TP*TP*TP*TP*TP*TP*TP*TP*TP*TP*TP*TP*T)-3', ADENOSINE-5'-DIPHOSPHATE, BERYLLIUM TRIFLUORIDE ION, ... 著者 Gu, M, Rice, C.M. 登録日 2009-11-17 公開日 2010-01-26 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Inaugural Article: Three conformational snapshots of the hepatitis C virus NS3 helicase reveal a ratchet translocation mechanism. Proc.Natl.Acad.Sci.USA, 107, 2010
5E0U	Human PCNA variant (S228I) complexed with p21 at 1.9 Angstroms 分子名称: Cyclin-dependent kinase inhibitor 1, Proliferating cell nuclear antigen 著者 Duffy, C.M, Hilbert, B.J, Kelch, B.A. 登録日 2015-09-29 公開日 2016-04-20 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (1.93 Å) 主引用文献 A Disease-Causing Variant in PCNA Disrupts a Promiscuous Protein Binding Site. J.Mol.Biol., 428, 2016
8RU2	Structure of the F-actin barbed end bound by formin mDia1 分子名称: ADENOSINE-5'-DIPHOSPHATE, Actin, cytoplasmic 1, ... 著者 Oosterheert, W, Boiero Sanders, M, Funk, J, Prumbaum, D, Raunser, S, Bieling, P. 登録日 2024-01-29 公開日 2024-04-10 最終更新日 2024-04-24 実験手法 ELECTRON MICROSCOPY (3.49 Å) 主引用文献 Molecular mechanism of actin filament elongation by formins. Science, 384, 2024
8RTY	Structure of the F-actin barbed end bound by Cdc12 and profilin (ring complex) at a resolution of 6.3 Angstrom 分子名称: ADENOSINE-5'-DIPHOSPHATE, Actin, cytoplasmic 1, ... 著者 Oosterheert, W, Boiero Sanders, M, Funk, J, Prumbaum, D, Raunser, S, Bieling, P. 登録日 2024-01-29 公開日 2024-04-10 最終更新日 2024-04-24 実験手法 ELECTRON MICROSCOPY (6.25 Å) 主引用文献 Molecular mechanism of actin filament elongation by formins. Science, 384, 2024
5E0V	Human PCNA variant (S228I) complexed with FEN1 at 2.1 Angstroms 分子名称: Flap endonuclease 1, Proliferating cell nuclear antigen 著者 Duffy, C.M, Hilbert, B.J, Kelch, B.A. 登録日 2015-09-29 公開日 2016-04-20 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (2.074 Å) 主引用文献 A Disease-Causing Variant in PCNA Disrupts a Promiscuous Protein Binding Site. J.Mol.Biol., 428, 2016
8HIO	Cryo-EM structure of the Cas12m2-crRNA binary complex 分子名称: Cas12m2, MAGNESIUM ION, RNA (56-MER), ... 著者 Omura, N.S, Nakagawa, R, Wu, Y.W, Sudfeld, C, Warren, V.R, Hirano, H, Kusakizako, T, Kise, Y, Lebbink, H.G.J, Itoh, Y, Oost, V.D.J, Nureki, O. 登録日 2022-11-21 公開日 2023-04-12 最終更新日 2023-08-30 実験手法 ELECTRON MICROSCOPY (3.73 Å) 主引用文献 Mechanistic and evolutionary insights into a type V-M CRISPR-Cas effector enzyme. Nat.Struct.Mol.Biol., 30, 2023
3KP3	Staphylococcus epidermidis in complex with ampicillin 分子名称: (2S,5R,6R)-6-{[(2R)-2-AMINO-2-PHENYLETHANOYL]AMINO}-3,3-DIMETHYL-7-OXO-4-THIA-1-AZABICYCLO[3.2.0]HEPTANE-2-CARBOXYLIC ACID, Transcriptional regulator TcaR 著者 Chang, Y.M, Chen, C.K, Wang, A.H. 登録日 2009-11-15 公開日 2010-06-09 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (3.2 Å) 主引用文献 Structural study of TcaR and its complexes with multiple antibiotics from Staphylococcus epidermidis. Proc.Natl.Acad.Sci.USA, 107, 2010
4W97	Structure of ketosteroid transcriptional regulator KstR2 of Mycobacterium tuberculosis 分子名称: CHLORIDE ION, HTH-type transcriptional repressor KstR2, S-[2-[3-[[(2R)-4-[[[(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-4-oxidanyl-3-phosphonooxy-oxolan-2-yl]methoxy-oxidanyl-phosphoryl]oxy-oxidanyl-phosphoryl]oxy-3,3-dimethyl-2-oxidanyl-butanoyl]amino]propanoylamino]ethyl] 3-[(3aS,4S,7aS)-7a-methyl-1,5-bis(oxidanylidene)-2,3,3a,4,6,7-hexahydroinden-4-yl]propanethioate 著者 Stogios, P.J, Evdokimova, E, Savchenko, A, Joachimiak, A, Midwest Center for Structural Genomics (MCSG) 登録日 2014-08-27 公開日 2014-11-26 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (1.6 Å) 主引用文献 Structural and Functional Characterization of a Ketosteroid Transcriptional Regulator of Mycobacterium tuberculosis. J.Biol.Chem., 290, 2015
1VZK	A Thiophene Based Diamidine Forms a "Super" AT Binding Minor Groove Agent 分子名称: 2-(5-{4-[AMINO(IMINO)METHYL]PHENYL}-2-THIENYL)-1H-BENZIMIDAZOLE-6- CARBOXIMIDAMIDE DIHYDROCHLORIDE, 5'-D(*CP*GP*CP*GP*AP*AP*TP*TP*CP*GP *CP*G)-3', MAGNESIUM ION 著者 Mallena, S, Lee, M.P.H, Bailly, C, Neidle, S, Kumar, A, Boykin, D.W, Wilson, W.D. 登録日 2004-05-20 公開日 2004-10-25 最終更新日 2023-12-13 実験手法 X-RAY DIFFRACTION (1.77 Å) 主引用文献 Thiophene-Based Diamidine Forms a "Super" at Binding Minor Groove Agent J.Am.Chem.Soc., 142, 2004
8BUM	Structure of DDB1 bound to DS15-engaged CDK12-cyclin K 分子名称: (2R)-2-[[6-(5-naphthalen-1-ylpentylamino)-9-propan-2-yl-purin-2-yl]amino]butan-1-ol, Cyclin-K, Cyclin-dependent kinase 12, ... 著者 Kozicka, Z, Kempf, G, Petzold, G, Thoma, N.H. 登録日 2022-11-30 公開日 2023-09-20 最終更新日 2024-01-03 実験手法 X-RAY DIFFRACTION (3.36 Å) 主引用文献 Design principles for cyclin K molecular glue degraders. Nat.Chem.Biol., 20, 2024
8BU7	Structure of DDB1 bound to 21195-engaged CDK12-cyclin K 分子名称: 1,2-ETHANEDIOL, 1-[2,6-bis(chloranyl)phenyl]-6-[[4-(2-hydroxyethyloxy)phenyl]methyl]-3-propan-2-yl-5H-pyrazolo[3,4-d]pyrimidin-4-one, Cyclin-K, ... 著者 Kozicka, Z, Kempf, G, Petzold, G, Thoma, N.H. 登録日 2022-11-30 公開日 2023-09-13 最終更新日 2024-01-03 実験手法 X-RAY DIFFRACTION (3.245 Å) 主引用文献 Design principles for cyclin K molecular glue degraders. Nat.Chem.Biol., 20, 2024
8BUN	Structure of DDB1 bound to DS16-engaged CDK12-cyclin K 分子名称: (2~{R})-2-[[6-[(4-phenylphenyl)methylamino]-9-propan-2-yl-purin-2-yl]amino]butan-1-ol, Cyclin-K, Cyclin-dependent kinase 12, ... 著者 Kozicka, Z, Kempf, G, Petzold, G, Thoma, N.H. 登録日 2022-11-30 公開日 2023-09-13 最終更新日 2024-01-03 実験手法 X-RAY DIFFRACTION (3.08 Å) 主引用文献 Design principles for cyclin K molecular glue degraders. Nat.Chem.Biol., 20, 2024
8BU2	Structure of DDB1 bound to DS18-engaged CDK12-cyclin K 分子名称: Cyclin-K, Cyclin-dependent kinase 12, DNA damage-binding protein 1, ... 著者 Kozicka, Z, Kempf, G, Petzold, G, Thoma, N.H. 登録日 2022-11-30 公開日 2023-09-13 最終更新日 2024-01-03 実験手法 X-RAY DIFFRACTION (3.13 Å) 主引用文献 Design principles for cyclin K molecular glue degraders. Nat.Chem.Biol., 20, 2024
8BUA	Structure of DDB1 bound to 919278-engaged CDK12-cyclin K 分子名称: (2~{R})-~{N}-(1~{H}-benzimidazol-2-yl)-2-(3-oxidanylidene-1~{H}-isoindol-2-yl)propanamide, CITRIC ACID, Cyclin-K, ... 著者 Kozicka, Z, Kempf, G, Petzold, G, Thoma, N.H. 登録日 2022-11-30 公開日 2023-09-13 最終更新日 2024-01-03 実験手法 X-RAY DIFFRACTION (3.193 Å) 主引用文献 Design principles for cyclin K molecular glue degraders. Nat.Chem.Biol., 20, 2024
8BUI	Structure of DDB1 bound to DRF-053-engaged CDK12-cyclin K 分子名称: (2~{R})-2-[[9-propan-2-yl-6-[(4-pyridin-2-ylphenyl)amino]purin-2-yl]amino]butan-1-ol, 1,2-ETHANEDIOL, Cyclin-K, ... 著者 Kozicka, Z, Kempf, G, Petzold, G, Thoma, N.H. 登録日 2022-11-30 公開日 2023-09-13 最終更新日 2024-01-03 実験手法 X-RAY DIFFRACTION (3.5 Å) 主引用文献 Design principles for cyclin K molecular glue degraders. Nat.Chem.Biol., 20, 2024
8BUR	Structure of DDB1 bound to DS50-engaged CDK12-cyclin K 分子名称: Cyclin-K, Cyclin-dependent kinase 12, DNA damage-binding protein 1, ... 著者 Kozicka, Z, Kempf, G, Focht, V, Thoma, N.H. 登録日 2022-11-30 公開日 2023-09-13 最終更新日 2024-03-27 実験手法 X-RAY DIFFRACTION (3.64 Å) 主引用文献 Design principles for cyclin K molecular glue degraders. Nat.Chem.Biol., 20, 2024
8BUF	Structure of DDB1 bound to Z12-engaged CDK12-cyclin K 分子名称: 2-(6,7-dihydro-4~{H}-thieno[3,2-c]pyridin-5-ylmethyl)-6,7-dimethoxy-3~{H}-quinazolin-4-one, Cyclin-K, Cyclin-dependent kinase 12, ... 著者 Kozicka, Z, Kempf, G, Petzold, G, Thoma, N.H. 登録日 2022-11-30 公開日 2023-09-13 最終更新日 2024-01-03 実験手法 X-RAY DIFFRACTION (3.3 Å) 主引用文献 Design principles for cyclin K molecular glue degraders. Nat.Chem.Biol., 20, 2024
8BU1	Structure of DDB1 bound to DS17-engaged CDK12-cyclin K 分子名称: (2~{R})-2-[[6-[[5,6-bis(chloranyl)-1~{H}-benzimidazol-2-yl]methylamino]-9-(1-methylpyrazol-4-yl)purin-2-yl]amino]butan-1-ol, Cyclin-K, Cyclin-dependent kinase 12, ... 著者 Kozicka, Z, Kempf, G, Petzold, G, Thoma, N.H. 登録日 2022-11-30 公開日 2023-09-13 最終更新日 2024-01-03 実験手法 X-RAY DIFFRACTION (2.98 Å) 主引用文献 Design principles for cyclin K molecular glue degraders. Nat.Chem.Biol., 20, 2024
6L87	Solution structure of the tandem PWWP-ARID domains of human RBBP1 分子名称: AT-rich interactive domain-containing protein 4A 著者 Gong, W.B, Perrett, S, Feng, Y.G. 登録日 2019-11-05 公開日 2021-01-06 最終更新日 2024-05-15 実験手法 SOLUTION NMR 主引用文献 Structural insight into chromatin recognition by multiple domains of the tumor suppressor RBBP1. J.Mol.Biol., 2021
6DK4	Crystal structure of Campylobacter jejuni peroxide stress regulator 分子名称: (4S)-2-METHYL-2,4-PENTANEDIOL, Ferric uptake regulation protein, MANGANESE (II) ION, ... 著者 Sarvan, S, Brunzelle, J.S, Couture, J.F. 登録日 2018-05-28 公開日 2018-06-13 最終更新日 2024-03-06 実験手法 X-RAY DIFFRACTION (2.71 Å) 主引用文献 Crystal structure of Campylobacter jejuni peroxide regulator. FEBS Lett., 592, 2018

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