1VZK

A Thiophene Based Diamidine Forms a "Super" AT Binding Minor Groove Agent

Summary for 1VZK

Related2DBE
Descriptor5'-D(*CP*GP*CP*GP*AP*AP*TP*TP*CP*GP *CP*G)-3', 2-(5-{4-[AMINO(IMINO)METHYL]PHENYL}-2-THIENYL)-1H-BENZIMIDAZOLE-6- CARBOXIMIDAMIDE DIHYDROCHLORIDE, MAGNESIUM ION, ... (4 entities in total)
Functional Keywordsnucleic acid, nucleic acids, minor groove binder, double helix, dna-drug complex, magnesium-water complex, dna hydration
Total number of polymer chains2
Total molecular weight7711.53
Authors
Mallena, S.,Lee, M.P.H.,Bailly, C.,Neidle, S.,Kumar, A.,Boykin, D.W.,Wilson, W.D. (deposition date: 2004-05-20, release date: 2004-10-25, Last modification date: 2011-07-13)
Primary citation
Mallena, S.,Lee, M.P.H.,Bailly, C.,Neidle, S.,Kumar, A.,Boykin, D.W.,Wilson, W.D.
Thiophene-Based Diamidine Forms a "Super" at Binding Minor Groove Agent
J.Am.Chem.Soc., 142:13659-, 2004
PubMed: 15493923 (PDB entries with the same primary citation)
DOI: 10.1021/JA048175M
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (1.77 Å)
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Structure validation

RfreeClashscoreRSRZ outliers0.23580MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution

More Asymmetric unit images

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Molmil generated image of 1vzk
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Molmil generated image of 1vzk
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