PDB: 10674 件ウェブページステータス検索Chemie searchBIRD

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6IMQ	Crystal structure of PML B1-box multimers 分子名称: CHLORIDE ION, Protein PML, ZINC ION 著者 Li, Y, Ma, X, Chen, Z, Wu, H, Wang, P, Wu, W, Cheng, N, Zeng, L, Zhang, H, Cai, X, Chen, S.J, Chen, Z, Meng, G. 登録日 2018-10-23 公開日 2019-07-31 最終更新日 2024-03-27 実験手法 X-RAY DIFFRACTION (2.06 Å) 主引用文献 B1 oligomerization regulates PML nuclear body biogenesis and leukemogenesis. Nat Commun, 10, 2019
5KRL	Crystal Structure of the ER-alpha Ligand-binding Domain (Y537S) in Complex with the A-CD ring estrogen, (1S,7aS)-5-(2-chloro-4-hydroxyphenyl)-7a-methyl-2,3,3a,4,7,7a-hexahydro-1H-inden-1-ol 分子名称: (1~{S},3~{a}~{R},7~{a}~{S})-5-(2-chloranyl-4-oxidanyl-phenyl)-2,3,3~{a},4,7,7~{a}-hexahydro-1~{H}-inden-1-ol, Estrogen receptor, NCOA2 著者 Nwachukwu, J.C, Srinivasan, S, Bruno, N.E, Nowak, J, Kojetin, D.J, Elemento, O, Katzenellenbogen, J.A, Nettles, K.W. 登録日 2016-07-07 公開日 2017-01-18 最終更新日 2024-03-06 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Systems Structural Biology Analysis of Ligand Effects on ER alpha Predicts Cellular Response to Environmental Estrogens and Anti-hormone Therapies. Cell Chem Biol, 24, 2017
5KRM	Crystal Structure of the ER-alpha Ligand-binding Domain (Y537S) in Complex with the A-CD ring estrogen, (1S,7aS)-5-(2,5-difluoro-4-hydroxyphenyl)-7a-methyl-2,3,3a,4,7,7a-hexahydro-1H-inden-1-ol 分子名称: (1~{S},3~{a}~{R},7~{a}~{S})-5-[2,5-bis(fluoranyl)-4-oxidanyl-phenyl]-7~{a}-methyl-1,2,3,3~{a},4,7-hexahydroinden-1-ol, Estrogen receptor, NCOA2 著者 Nwachukwu, J.C, Srinivasan, S, Bruno, N.E, Nowak, J, Kojetin, D.J, Elemento, O, Katzenellenbogen, J.A, Nettles, K.W. 登録日 2016-07-07 公開日 2017-01-18 最終更新日 2024-03-06 実験手法 X-RAY DIFFRACTION (2.24 Å) 主引用文献 Systems Structural Biology Analysis of Ligand Effects on ER alpha Predicts Cellular Response to Environmental Estrogens and Anti-hormone Therapies. Cell Chem Biol, 24, 2017
5KR9	Crystal Structure of the ER-alpha Ligand-binding Domain (Y537S) in Complex with Coumestrol 分子名称: Coumestrol, Estrogen receptor, NCOA2 著者 Nwachukwu, J.C, Srinivasan, S, Bruno, N.E, Nowak, J, Kojetin, D.J, Elemento, O, Katzenellenbogen, J.A, Nettles, K.W. 登録日 2016-07-07 公開日 2017-02-15 最終更新日 2024-03-06 実験手法 X-RAY DIFFRACTION (2.25 Å) 主引用文献 Systems Structural Biology Analysis of Ligand Effects on ER alpha Predicts Cellular Response to Environmental Estrogens and Anti-hormone Therapies. Cell Chem Biol, 24, 2017
2IZR	Structure of casein kinase gamma 3 in complex with inhibitor 分子名称: CASEIN KINASE I ISOFORM GAMMA-3, CHLORIDE ION, MAGNESIUM ION, ... 著者 Bunkoczi, G, Salah, E, Rellos, P, Das, S, Fedorov, O, Savitsky, P, Debreczeni, J.E, Gileadi, O, Sundstrom, M, Edwards, A, Arrowsmith, C, Weigelt, J, von Delft, F, Knapp, S. 登録日 2006-07-26 公開日 2006-08-01 最終更新日 2023-12-13 実験手法 X-RAY DIFFRACTION (1.3 Å) 主引用文献 Inhibitor Binding by Casein Kinases To be Published
5KRK	Crystal Structure of the ER-alpha Ligand-binding Domain (Y537S) in Complex with 4,4'-((5-bromo-2,3-dihydro-1H-inden-1-ylidene)methylene)diphenol 分子名称: 4-[(5-bromanyl-2,3-dihydroinden-1-ylidene)-(4-hydroxyphenyl)methyl]phenol, Estrogen receptor, NCOA2 著者 Nwachukwu, J.C, Srinivasan, S, Bruno, N.E, Nowak, J, Kojetin, D.J, Elemento, O, Katzenellenbogen, J.A, Nettles, K.W. 登録日 2016-07-07 公開日 2017-01-18 最終更新日 2024-03-06 実験手法 X-RAY DIFFRACTION (2.391 Å) 主引用文献 Systems Structural Biology Analysis of Ligand Effects on ER alpha Predicts Cellular Response to Environmental Estrogens and Anti-hormone Therapies. Cell Chem Biol, 24, 2017
2IZU	Structure of casein kinase gamma 3 in complex with inhibitor 分子名称: 1,2-ETHANEDIOL, 2-({6-[(3-CHLOROPHENYL)AMINO]-9-ISOPROPYL-9H-PURIN-2-YL}AMINO)-3-METHYLBUTAN-1-OL, CASEIN KINASE I ISOFORM GAMMA-3, ... 著者 Bunkoczi, G, Salah, E, Rellos, P, Das, S, Fedorov, O, Savitsky, P, Debreczeni, J.E, Gileadi, O, Sundstrom, M, Edwards, A, Arrowsmith, C, Weigelt, J, von Delft, F, Knapp, S. 登録日 2006-07-26 公開日 2006-08-01 最終更新日 2023-12-13 実験手法 X-RAY DIFFRACTION (1.85 Å) 主引用文献 Inhibitor Binding by Casein Kinases To be Published
6AV2	Structure of human neuronal nitric oxide synthase R354A/G357D mutant heme domain in complex with 6-(3-(3-(dimethylamino)propyl)-5-(trifluoromethyl)phenethyl)-4-methylpyridin-2-amine 分子名称: 5,6,7,8-TETRAHYDROBIOPTERIN, 6-(2-{3-[3-(dimethylamino)propyl]-5-(trifluoromethyl)phenyl}ethyl)-4-methylpyridin-2-amine, Nitric oxide synthase, ... 著者 Li, H, Poulos, T.L. 登録日 2017-09-01 公開日 2018-07-11 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Improvement of Cell Permeability of Human Neuronal Nitric Oxide Synthase Inhibitors Using Potent and Selective 2-Aminopyridine-Based Scaffolds with a Fluorobenzene Linker. J. Med. Chem., 60, 2017
1L8Y	Solution structure of HMG box 5 in human upstream binding factor 分子名称: upstream binding factor 1 著者 Yang, W, Xu, Y, Wu, J, Zeng, W, Shi, Y. 登録日 2002-03-22 公開日 2002-06-05 最終更新日 2024-05-29 実験手法 SOLUTION NMR 主引用文献 Solution structure and DNA binding property of the fifth HMG box domain in comparison with the first HMG box domain in human upstream binding factor Biochemistry, 42, 2003
6AZ1	Cryo-EM structure of the small subunit of Leishmania ribosome bound to paromomycin 分子名称: E-site tRNA, LACK1, MAGNESIUM ION, ... 著者 Shalev-Benami, M, Zhang, Y, Rozenberg, H, Matzov, D, Zimmerman, E, Bashan, A, Jaffe, C.L, Yonath, A, Skiniotis, G. 登録日 2017-09-09 公開日 2017-12-06 最終更新日 2019-07-03 実験手法 ELECTRON MICROSCOPY (2.7 Å) 主引用文献 Atomic resolution snapshot of Leishmania ribosome inhibition by the aminoglycoside paromomycin. Nat Commun, 8, 2017
2IZT	Structure of casein kinase gamma 3 in complex with inhibitor 分子名称: CASEIN KINASE I ISOFORM GAMMA-3, CHLORIDE ION, N2-[(1R,2S)-2-AMINOCYCLOHEXYL]-N6-(3-CHLOROPHENYL)-9-ETHYL-9H-PURINE-2,6-DIAMINE 著者 Bunkoczi, G, Salah, E, Rellos, P, Das, S, Fedorov, O, Savitsky, P, Debreczeni, J.E, Gileadi, O, Sundstrom, M, Edwards, A, Arrowsmith, C, Weigelt, J, von Delft, F, Knapp, S. 登録日 2006-07-26 公開日 2006-08-01 最終更新日 2023-12-13 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Inhibitor Binding by Casein Kinases To be Published
6ATV	The molecular mechanisms by which NS1 of the 1918 Spanish influenza A virus hijack host protein-protein interactions 分子名称: Adapter molecule crk, proline-rich motif in IAV-NS1 著者 Shen, Q, Zeng, D, Zhao, B, Li, P, Cho, J.H. 登録日 2017-08-29 公開日 2018-08-08 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (1.751 Å) 主引用文献 Molecular Mechanisms of Tight Binding through Fuzzy Interactions. Biophys. J., 114, 2018
6AUT	Structure of rat neuronal nitric oxide synthase heme domain in complex with 6-(3-(3-(Dimethylamino)propyl)-5-fluorophenethyl)-4-methylpyridin-2-amine 分子名称: 5,6,7,8-TETRAHYDROBIOPTERIN, 6-(2-{3-[3-(dimethylamino)propyl]-5-fluorophenyl}ethyl)-4-methylpyridin-2-amine, ACETATE ION, ... 著者 Li, H, Poulos, T.L. 登録日 2017-09-01 公開日 2018-07-11 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Improvement of Cell Permeability of Human Neuronal Nitric Oxide Synthase Inhibitors Using Potent and Selective 2-Aminopyridine-Based Scaffolds with a Fluorobenzene Linker. J. Med. Chem., 60, 2017
6IC6	Human cathepsin-C in complex with cyclopropyl peptidyl nitrile inhibitor 1 分子名称: (2~{S})-~{N}-[(1~{R},2~{R})-1-(aminomethyl)-2-[4-[4-(trifluoromethyl)phenyl]phenyl]cyclopropyl]-2-azanyl-butanamide, 2-acetamido-2-deoxy-beta-D-glucopyranose, CHLORIDE ION, ... 著者 Hakansson, M, Logan, D.T, Korkmaz, B, Lesner, A, Wysocka, M, Gieldon, A, Gauthier, F, Jenne, D, Lauritzen, C, Pedersen, J. 登録日 2018-12-02 公開日 2019-04-24 最終更新日 2024-05-01 実験手法 X-RAY DIFFRACTION (1.898 Å) 主引用文献 Structure-based design and in vivo anti-arthritic activity evaluation of a potent dipeptidyl cyclopropyl nitrile inhibitor of cathepsin C. Biochem. Pharmacol., 164, 2019
6GPA	Beta-1,4-galactanase from Bacteroides thetaiotaomicron with galactose 分子名称: Arabinogalactan endo-beta-1,4-galactanase, beta-D-galactopyranose 著者 Hekelaar, J, Boger, M, Leeuwen van, S.S, Lammerts van Bueren, A, Dijkhuizen, L. 登録日 2018-06-05 公開日 2018-12-26 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (1.79 Å) 主引用文献 Structural and functional characterization of a family GH53 beta-1,4-galactanase from Bacteroides thetaiotaomicron that facilitates degradation of prebiotic galactooligosaccharides. J. Struct. Biol., 205, 2019
1L8Z	Solution structure of HMG box 5 in human upstream binding factor 分子名称: upstream binding factor 1 著者 Yang, W, Xu, Y, Wu, J, Zeng, W, Shi, Y. 登録日 2002-03-22 公開日 2002-06-05 最終更新日 2024-05-29 実験手法 SOLUTION NMR 主引用文献 Solution structure and DNA binding property of the fifth HMG box domain in comparison with the first HMG box domain in human upstream binding factor Biochemistry, 42, 2003
6AUX	Structure of rat neuronal nitric oxide synthase heme domain in complex with 6-(2-(5-Fluoro-3'-((methylamino)methyl)-[1,1'-biphenyl]-3-yl)ethyl)-4-methylpyridin-2-amine 分子名称: 5,6,7,8-TETRAHYDROBIOPTERIN, 6-(2-{5-fluoro-3'-[(methylamino)methyl][1,1'-biphenyl]-3-yl}ethyl)-4-methylpyridin-2-amine, ACETATE ION, ... 著者 Li, H, Poulos, T.L. 登録日 2017-09-01 公開日 2018-07-11 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Improvement of Cell Permeability of Human Neuronal Nitric Oxide Synthase Inhibitors Using Potent and Selective 2-Aminopyridine-Based Scaffolds with a Fluorobenzene Linker. J. Med. Chem., 60, 2017
6AV7	Structure of human endothelial nitric oxide synthase heme domain in complex with HW69 分子名称: 2-[BIS-(2-HYDROXY-ETHYL)-AMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, 5,6,7,8-TETRAHYDROBIOPTERIN, 6-(2-{3-[3-(dimethylamino)propyl]-5-fluorophenyl}ethyl)-4-methylpyridin-2-amine, ... 著者 Li, H, Poulos, T.L. 登録日 2017-09-01 公開日 2018-07-11 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (1.916 Å) 主引用文献 Improvement of Cell Permeability of Human Neuronal Nitric Oxide Synthase Inhibitors Using Potent and Selective 2-Aminopyridine-Based Scaffolds with a Fluorobenzene Linker. J. Med. Chem., 60, 2017
7UJJ	Stx2a and DARPin complex 分子名称: 1,2-ETHANEDIOL, 3-PYRIDINIUM-1-YLPROPANE-1-SULFONATE, DARPin, ... 著者 Jiang, M, Zhang, J. 登録日 2022-03-30 公開日 2023-04-12 実験手法 ELECTRON MICROSCOPY (6.5 Å) 主引用文献 A Multi-Specific DARPin Potently Neutralizes Shiga Toxin 2 via Simultaneous Modulation of Both Toxin Subunits. Bioengineering (Basel), 9, 2022
8JYW	Cryo-EM structure of the gasdermin pore from Trichoplax adhaerens 分子名称: Gasdermin pore forming domain-containing protein 著者 Hou, Y.J, Sun, Q, Zeng, H, Ding, J. 登録日 2023-07-04 公開日 2024-05-01 最終更新日 2024-05-29 実験手法 ELECTRON MICROSCOPY (3.3 Å) 主引用文献 Cleavage-independent activation of ancient eukaryotic gasdermins and structural mechanisms. Science, 384, 2024
5KRJ	Crystal Structure of the ER-alpha Ligand-binding Domain (Y537S) in Complex with an a-naphthyl Substituted OBHS derivative 分子名称: Estrogen receptor, NCOA2, naphthalen-1-yl (1~{S},2~{R},4~{S})-5,6-bis(4-hydroxyphenyl)-7-oxabicyclo[2.2.1]hept-5-ene-2-sulfonate 著者 Nwachukwu, J.C, Srinivasan, S, Bruno, N.E, Nowak, J, Kojetin, D.J, Elemento, O, Katzenellenbogen, J.A, Nettles, K.W. 登録日 2016-07-07 公開日 2017-01-18 最終更新日 2024-03-06 実験手法 X-RAY DIFFRACTION (2.7 Å) 主引用文献 Systems Structural Biology Analysis of Ligand Effects on ER alpha Predicts Cellular Response to Environmental Estrogens and Anti-hormone Therapies. Cell Chem Biol, 24, 2017
8KHR	Cryo-EM structure of EBV gH/gL-gp42 in complex with fab 2C1 分子名称: 2C1 heavy chain, 2C1 light chain, Envelope glycoprotein H, ... 著者 Fang, X.Y, Zhao, G.X, Zeng, M.S, Liu, Z. 登録日 2023-08-22 公開日 2024-06-19 実験手法 ELECTRON MICROSCOPY (3.25 Å) 主引用文献 Potent human monoclonal antibodies targeting Epstein-Barr virus gp42 reveal vulnerable sites for virus infection. Cell Rep Med, 5, 2024
6IV7	The crystal structure of a SAM-dependent enzyme from aspergillus flavus 分子名称: S-ADENOSYL-L-HOMOCYSTEINE, methyltransferase lepI 著者 Zhou, Y.Z, Peng, T, Liao, L.J, Liu, X.K, Zhao, Y.C, Guo, Y, Zeng, Z.X. 登録日 2018-12-02 公開日 2019-02-06 最終更新日 2024-03-27 実験手法 X-RAY DIFFRACTION (1.937 Å) 主引用文献 The crystal structure of A SAM-Dependent enzyme from Aspergillus flavus To Be Published
1NJN	The crystal structure of the 50S Large ribosomal subunit from Deinococcus radiodurans complexed with the antibiotic sparsomycin 分子名称: 23S ribosomal RNA, SPARSOMYCIN 著者 Bashan, A, Agmon, I, Zarivatch, R, Schluenzen, F, Harms, J.M, Berisio, R, Bartels, H, Hansen, H.A, Yonath, A. 登録日 2003-01-02 公開日 2003-02-11 最終更新日 2023-08-16 実験手法 X-RAY DIFFRACTION (3.7 Å) 主引用文献 Structural basis of the ribosomal machinery for Peptide bond formation, translocation, and nascent chain progression Mol.Cell, 11, 2003
5J4U	Crystal structure of a glutathione S-transferase PtGSTU30 from Populus trichocarpa in complex with GSH 分子名称: GLUTATHIONE, Glutathione transferase family protein 著者 Yang, Q, Gu, J, Yang, M, Zeng, Q. 登録日 2016-04-01 公開日 2017-04-12 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (1.249 Å) 主引用文献 Functional and Structural Profiles of GST Gene Family from Three Populus Species Revealed the Sequence-function Decoupling of Orthologous Genes To Be Published

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